标题:
肉桂酸羽扇烷醇酯的合成及其抗癌活性Synthesis of Lupanol Cinnamate and Its Anticancer Activities
作者:
李伟杰
关键字:
肉桂酸羽扇烷醇酯, 合成, 抗癌活性Lupanol Cinnamate, Synthesis, Anticancer Activity
期刊名称:
《Journal of Organic Chemistry Research》, Vol.4 No.1, 2016-03-07
摘要:
以N,N'-二环己基碳二亚胺(DCC)为缩合剂，4-二甲氨基吡啶(DMAP)为催化剂，羽扇烷醇和肉桂酸在二氯甲烷中室温反应24 h，合成了新化合物肉桂酸羽扇烷醇酯，产率为81.6%。研究了肉桂酸羽扇烷醇酯体外对食管鳞癌细胞Eca-109、TE-1和EC-9706增殖的抑制活性。结果表明肉桂酸羽扇烷醇酯对上述3株实验癌细胞的增殖均有良好的抑制活性，其抗癌活性与阿霉素相近。
Lupanol was reacted with cinnamic acid for 24 h in dichloromethane at room temperature to give lupanol cinnamate at 81.6% yield in the presence of N,N'-dicyclohexylcarbodiimide (DDC) as dehydrating agent and 4-dimethylaminopyridine (DMAP) as catalyst. It was evaluated for in vitro antitumor activities against the human esophageal squamous cell carcinoma cell lines Eca- 109, TE-1 and EC-9706. The results showed that lupanol cinnamate had good inhibitory activities against the above three tested cancer cell lines and its anticancer activities were near to those of adriamycin.