标题:
产前应激对子代大鼠学习记忆及焦虑行为的影响研究Effects of Prenatal Stress on Anxiety of Behavior and Learning and Memory of Offspring Rats
作者:
蒋英虹, 王义强, 连波, 王钢, 孙宏伟, 姜能志, 孙琳
关键字:
产前应激, 慢性轻度不可预计应激, 子代大鼠, 学习记忆, 焦虑Prenatal Stress, Chronic Mild Unpredictable Stress (CUS), Offspring Rats, Learning and Memory, Anxiety
期刊名称:
《International Journal of Psychiatry and Neurology》, Vol.5 No.2, 2016-05-20
摘要:
目的：探讨母鼠妊娠后经历慢性轻度不可预计应激对其子代学习记忆和焦虑行为的影响。方法：应激组母鼠在怀孕时进行慢性应激干预，每日随机选取两种刺激(如湿笼、禁水食、束缚刺激等)；而对照组母鼠不进行任何处理。子代大鼠于青春前期(28 d)和青春后期(49 d)进行Morris水迷宫试验；并在青春期后期(49 d)进行旷场实验。结果：对照组子鼠相比，应激组子鼠体重增长明显减缓(F = 13.098, *p
Objective: To determine the effect of prenatal chronic unpredictable mild stress (CUS) during the pregnancy on the behavior parameters of learning and memory and anxiety of the rat offspring. Methods: The prenatal CUS model was adopted. During pregnancy to fertility, the mothers of CUS group underwent two stimuli daily randomly (such as wet, 45˚ inclined cage, cage ban water feed, bound to stimulate, etc.); While the mothers of control group didn’t deal with any processing. The offspring rats from each group were examined in Morris Water Maze at preadolescence (28 d) and postpubescence (49 d), and examined the spontaneous behavior and anxiety behavior by the open-field test at postpubescence (49 d). Results: CUS influences on growth of rat body weight (F = 13.098, *P