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外周血中性粒细胞与淋巴细胞比值在乳腺癌各分子分型预后中的意义Significance of Peripheral Blood Neutrophil to Lymphocyte Ratio in the Prognosis of Breast Cancer
王真真, 杨雁鸿, 冯博, 冯悦, 李倩影, 王小玉
乳腺癌, 中性粒细胞, 淋巴细胞, 中性粒细胞/淋巴细胞比值(NLR), 分子分型, 预后Breast Cancer, Neutrophil, Lymphocyte, Neutrophil-to-Lymphocyte Ratio (NLR), Molecular Subtype, Prognosis
《Asian Case Reports in Oncology》, Vol.5 No.1, 2016-07-29
目的：本研究旨在探讨NLR与乳腺癌各分子分型预后的关系。方法：回顾性研究秦皇岛市第一医院2009年1月至2011年1月经过病理学确诊的初治乳腺癌患者263例，通过ROC曲线，兼顾敏感性及特异性确定NLR截点(NLR = 2.08)，分为高NLR组(NLR > 2.08)和低NLR组(NLR 2.08组65.00%，NLR 2.08乳腺癌患者较NLR
Objective: We performed this study of breast cancer patients to evaluate the prognostic value of the NLR. Methods: We retrospectively analyzed 263 cases of breast cancer patients treated in The First Hospital of Qinhuangdao after pathology diagnosis from January 2009 to January 2011. According to the ROC curve, while taking into account the sensitivity and specificity, we selected NLR = 2.08 as the cut-off value, and divided the patients into low NLR group (NLR 2.08). Statistical analysis was performed with the statistical package for the social sciences (SPSS) software package version 19.0. We explore the relationship between NLR and clinical factors on prognosis by calculating 5-year survival rate. Results: 1) In term of age, history of cancer and menopausal status, there was no statistically significant difference. NLR difference between lower and upper groups has statistics significance (P 2.08 group, it was 65.00%; in NLR 2.08 is worse than that in patients with NLR