标题:
三氟甲磺酸盐催化硝化制备氟他胺Nitration Catalyzed by Metal Triflates to Improve the Synthesis of Flutamide
作者:
黄东, 朱占元
关键字:
氟他胺, 三氟甲磺酸盐, 催化硝化Flutamide, Metal Triflates, Catalytic Nitration
期刊名称:
《Open Journal of Natural Science》, Vol.4 No.3, 2016-08-22
摘要:
目的：对氟他胺硝化传统工艺进行改进，避免浓硫酸的大量使用，建立一个低污染新方法；方法：利用三氟甲磺酸的镧系金属盐作为催化剂、浓硝酸作为硝化剂完成硝化反应；结果：在1,2-二氯乙烷中，以三氟甲磺酸盐为催化剂、95%浓硝酸为硝化剂，氟他胺前体85℃下反应4小时，后处理可得到淡黄色针状结晶氟他胺产品，收率60%，HPLC检测纯度为99.84%；结论：该方法可以避免浓硫酸的使用，可以制备合格的氟他胺。
Objective: Improve the traditional nitration technology for flutamide to avoid using a large quantity of concentrated sulfuric acid and establish a new preparation method with low pollution. Method: Using trifluoromethanesulfonic acid-lanthanide bis (1,1,3,3 hexafluoro 2 propoxy) sulfonylamide as catalyst and concentrated nitric acid as nitration agent to carry out the nitration reaction. Results: The nitration reaction between the precursor of flutamide and 95% concentrated nitric acid is catalyzed by metal triflates in 1,2-dicloroethane, and the reaction temperature and time are 85˚C and 4 hours, respectively. After processing, a pale yellow needle-shaped flutamide is obtained with the yield of 60% and the purity of 99.84% by HPLC. Conclusion: This method can be used to prepare qualified flutamide without using concentrated sulfuric acid.