标题:
血清唾液酸浓度与2型糖尿病患者全视网膜光凝术后黄斑水肿的关系Relationship between Serum Sialic Acid Concentration and Macular Edema in Patients with Type 2 Diabetes Mellitus Treated with Panretinal Photocoagulation
作者:
郭疆, 林贞丽, 孔庆慧, 窦晓燕, 毛泽春
关键字:
血清唾液酸, 糖尿病视网膜病变, 黄斑水肿, 全视网膜激光光凝Serum Sialic Acid, Diabetic Retinopathy, Macular Edema, Panretinal Photocoagulation
期刊名称:
《Hans Journal of Ophthalmology》, Vol.5 No.3, 2016-09-19
摘要:
目的：探讨2型糖尿病患者血清唾液酸浓度与全视网膜激光光凝术后糖尿病性黄斑水肿的相关性。方法：选取102例2型糖尿病患者，糖尿病视网膜病变分级均为III~IV期，激光治疗前均无黄斑水肿病变。由同一医生分4次进行全视网膜激光光凝治疗，观察激光治疗后黄斑水肿情况。采取外周静脉血后用比色法测量血清唾液酸浓度，用视网膜血管荧光造影方法判断黄斑区水肿程度。结果：102例糖尿病患者平均血清唾液酸浓度为106.65 ± 10.21 mmol/l，激光治疗后发生糖尿病性黄斑水肿的患者为22例，其中1级水肿10例，2级水肿5例，3级水肿7例。未发生黄斑水肿的患者血清唾液酸浓度为96.33 ± 10.39 mmol/l，发生黄斑水肿的患者中血清唾液酸浓度为120.01 ± 17.71 mmol/l，两者差异具有统计学意义(P
Objective: To explore the association between serum sialic acid concentration and macular edema in patients with type 2 Diabetes mellitus treated with panretinal photocoagulation (PRP). Method： A total of 102 type 2 Diabetes mellitus patients with III-IV diabetic retinopathy but without macular edema were enrolled. They were treated with 4 times of panretinal photocoagulation by the same physician and the occurrence of macular edema was recorded. Then used the peripheral venous blood to test the serum sialic acid by colorimetry and graded the macular edema based on fundus fluorescein angiography (FFA). Result: The mean serum sialic acid concentration of 102 diabetes patients was 106.65 ± 10.21 mmol/l. 22 patients had macular edema after the PRP treatment, including ten with Grade 1 macular edema, five with Grade 2 macular edema and seven with Grade 3 macular edema. The mean serum sialic acid concentration of the patients without and with macular edema was 96.33 ± 10.39 mmol/l and 120.01 ± 17.71 mmol/l, respectively. The difference was statistically (P