标题:
食管鳞癌组织中nm23-H1和E-cadherin的表达及临床意义The Expression and Clinical Significance of nm23-H1 and E-Cadherin in Esophageal Squamous Cell Carcinomas
作者:
廖谦和, 毛飞, 徐丹
关键字:
食管鳞状细胞癌, nm23-H1, E-cadherin, 免疫组织化学Esophageal Squamous Cell Carcinomas, nm23-H1, E-Cadherin, Immunohistochemistry
期刊名称:
《Advances in Clinical Medicine》, Vol.6 No.4, 2016-11-03
摘要:
目的：研究转移抑制基因(nm23-H1)和E-钙粘附蛋白(E-cadherin)在食管鳞癌组织中表达情况，了解两者之间的相关性及其与临床病理特征的关系。方法：采用免疫组化EnVision法检测60例食管鳞癌组织中nm23-H1和E-cadherin的表达情况，比较其相关性。结果：食管鳞癌组织中nm23-H1和E-cadherin的阳性表达率分别为38.3% (23/60)和41.7% (25/60)，正常食管黏膜组织中nm23-H1和E-cadherin的阳性表达均为90.0% (9/10)，nm23-H1和E-cadherin在食管鳞癌组织中的阳性表达率显著低于正常食管黏膜组织。nm23-H1、E-cadherin表达与食管癌患者的年龄、性别、组织类型无关(P > 0.05)，而与肿瘤分化程度、浸润深度、区域淋巴结转移及TNM分期有关(P
Objective: The objective is to investigate the expressions of nm23-H1 and E-cadherin in esophageal squamous cell carcinomas, and to explore the correlation between the two and its relationship with clinical pathological features. Methods: The expressions of nm23-H1 and E-cadherin in the tumor tissues of 60 patients with esophageal squamous cell carcinomas were examined immuno-histochemistrically by the EnVision method, and their relationships were compared. Results: The positive rates of nm23-H1 and E-cadherin in expression in the esophageal squamous cell car-cinomas tissue were 38.3% (23/60) and 41.7% (25/60), respectively. The positive rates of nm23-H1 and E-cadherin in expression in the normal esophageal mucosa were 90.0% (9/10). The positive expression rates of nm23-H1 and E-cadherin in esophageal squamous cell carcinomas were significantly lower than those in normal esophageal mucosa. The expression of nm23-H1 and E-cadherin had no significant correlation with the patients’ age, sex, histological type (P > O.05), but had correlation with degree of the differentiation, depth of tumor invasion, regional lymph node metastasis and TNM stage (P