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Ragavendran, J.V., Sriram, D., Patel, S.K., Reddy, I.V., Bharathwajan, N. and Stables, J. (2007) Design and Synthesis of Anticonvulsants from a Combined Phthalimide-Gaba-Anilide and Hydrazone Pharmacophore. European Journal of Medicinal Chemistry, 42, 146-151. https://doi.org/10.1016/j.ejmech.2006.08.010

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• 标题: 磷钨酸促进的酰肼与查尔酮缩合反应的研究Study on the Condensation Reaction of Hydrazide with Benzylideneacetophenone Catalyzed by Phosphotungstic Acid

  作者: 吴阳, 邢雪建, 邢刘桩, 侯亚东, 杨敬辉, 惠永海

  关键字: 杂多酸, 缩合反应, 酰腙Heteropoly Acid, Condensation Reaction, Acylhydrazone

  期刊名称: 《Journal of Organic Chemistry Research》, Vol.4 No.4, 2016-12-02

  摘要: 本文以杂多酸–磷钨酸为催化剂，对酰肼与查尔酮的缩合反应进行了研究。经过一系列反应条件的筛选，确立了最佳反应条件，并对底物的普适性进行了考察，得到了一系列高产率的酰腙类目标产物，最高产率达到99%。本反应操作简单，条件温和，为查尔酮酰腙合成提供了一种新的方法。 The condensation of hydrazide with benzylideneacetophenone was studied by using phospho-tungstic acid as catalyst. After a series of reaction conditions, the optimal reaction conditions were established, and the universality of the substrate was investigated. A series of acylhydrazones were obtained with the high yields, up to 99%. The reaction was simple and mild, which provided a new method for the synthesis of chalcone hydrazone.