标题:
2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成及分析Synthesis and Analysis of 2-Chloromethyl-3,5-Dimethyl-4-Methoxypyridine
作者:
陈向莹, 范芳芳, 夏佳美, 张千峰
关键字:
2, 3, 5-二甲基吡啶, 2-氯甲基-3, 5-甲基-4-甲氧基吡啶, 中间体, 分析2, 3, 5-Trimethylpyridine, 2-Chloromethyl-3, 5-Dimethyl-4-Methoxypyridine, Intermediate, Analysis
期刊名称:
《Journal of Organic Chemistry Research》, Vol.4 No.4, 2016-12-09
摘要:
以2,3,5-三甲基吡啶为起始原料,经N-氧化、硝化、亲核取代、重排水解和氯甲基化等五大步骤而制得2-氯甲基-3,5-二甲基-4-甲氧基吡啶的合成与工艺。并通过1HNMR、FT-IR、HPLC等测试手段对2-氯甲基-3,5-二甲基-4-甲氧基吡啶产品进行定性和定量分析。
2-Chloromethyl-3,5-dimethyl-4-methoxypyridine was synthesized by use of 2,3,5-trimethylpyridine as the starting material. The synthetic route contains five steps including N-oxidation, nitration, nu-cleophilic substitution, alcoholation and chloromethylation. The target product was qualitatively and quantitatively analyzed using 1H NMR, FT-IR, and HPLC testing methods.