文章引用说明 更多>> (返回到该文章)

M. Krausch, A. Raff el, M. Anlauf, et al. Loss of PTEN expres- sion in neuroendocrine pancreatic tumors. Hormone and Meta- bolic Research, 2011, 43: 865-871.

被以下文章引用:

  • 标题: miR-21 与胰腺癌miR-21 and Pancreatic Cancer

    作者: 张莉娜, 张弘

    关键字: miR-21, 靶基因, 胰腺癌miR-21; Target Genes; Pancreatic Cancer

    期刊名称: 《World Journal of Cancer Research》, Vol.3 No.1, 2013-05-06

    摘要: 微小RNA(microRNA, miRNA)是一类内源性小分子单链RNA,在细胞增殖、分化、凋亡尤其是肿瘤发生发展等生理病理过程中发挥重要作用。miR-21 是研究最早也是较特殊的miRNA 之一,其在几乎所有的实体肿瘤包括胰腺癌中高表达。miR-21 通过作用于靶基因调控胰腺癌发生发发展,在胰腺癌细胞增殖、分化、迁移、侵袭以及肿瘤耐药性等起发面关键作用,有望成为胰腺癌诊断、治疗以及判断预后的潜在的生物标志物,有着潜在的临床应用价值。 MicroRNAs (miRNAs) are a class of single-stranded, evolutionary conserved, noncoding RNA molecules,which play important roles in various physiological or pathological processes, such as cell proliferation, differentiation,apoptosis, and especially tumorigenesis. All of them, miR-21 is one of the first studied and most special miRNAs as it is over expressed in nearly all of soil tumors. miR-21 has been shown to regulate the progression of pancreatic caner by targeting tumor suppressor or oncogenes, playing a key role in cell proliferation, differentiation, migration, invasion and drug resistance of pancreatic cancer. Therefore, miR-21 will possibly be a potential biomarker for diagnosis, therapy and prognosis of pancreatic cancer, showing potentially clinical value.

在线客服:
对外合作:
联系方式:400-6379-560
投诉建议:feedback@hanspub.org
客服号

人工客服,优惠资讯,稿件咨询
公众号

科技前沿与学术知识分享