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白丹, 余加林, 万珍艳等 (2008) 铜绿假单胞菌生物膜悬液和藻酸盐对小鼠巨噬细胞吞噬功能的影响. 中国微生态学杂志, 20, 337-342.

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  • 标题: 细菌生物膜的形成及耐药机制研究进展Progress on Bacterial Biofilm Formation and Antibiotics Resistance Mechanisms

    作者: 周敏, 尤理想, 赵青, 李嫄渊, 吴淑燕, 黄瑞

    关键字: 细菌生物膜, 耐药性, 耐药基因, 质粒Bacterial Biofilm; Antibiotic Resistance; Drug Resistance Genes; Plasmid

    期刊名称: 《Advances in Microbiology》, Vol.2 No.4, 2013-12-24

    摘要: 细菌对抗生素的耐药性已成为全球关注的医学及社会问题,细菌生物被膜(Bacterial biofilm, BBF)是细菌耐药性产生的一个重要方面。BBF是由细菌及其产生的胞外大分子多聚物形成的一种特殊细菌群落。这种细菌群落具有特殊的空间结构,能产生很强的屏障作用,抵抗抗生素的杀菌作用,并且可以加强群落内细菌的交流,传递耐药基因。在耐药基因的传递过程中,质粒作为基因的载体起到了极大的作用。同时,BBF与基因表达存在相互影响的关系。对BBF、耐药基因及质粒的研究,可以提高对BBF耐药性播散的认识,有助于防治细菌耐药性。 Bacterial resistance to antibiotics has become a global medical and social issue. Bacterial biofilm (BBF) is an important aspect of bacterial resistance. It is a special bacterial community formed by bacteria and their extracellular polymeric matrix. It has a special spatial structure that can produce a strong barrier to resist antibiotics, enhance the communication among bacteria and transfer the resistance genes. In the process of the transmission of resistance genes, plasmid plays a great role as gene vector. Meanwhile, BBF interacts closely with gene expression. The research on BBF, plasmid and drug resistance genes can facilitate understanding of the spread and prevention of BBF resistance.