标题:
恶性卵巢癌抗肿瘤间质治疗策略研究进展The Progress of Antitumor Interstitial Treatment Strategy of Malignant Ovarian Cancer
作者:
郭振超, 张天柱, 顾宁
关键字:
卵巢癌, 化疗耐药, 肿瘤间质, 生存率Ovarian Cancer; Chemotherapy Resistance; Tumor Interstitium; Survival Rate
期刊名称:
《Asian Case Reports in Obstetrics and Gynecology》, Vol.1 No.4, 2014-05-13
摘要:
超过80%的卵巢癌患者对化疗药物出现耐药性而复发，使得卵巢癌死亡率居妇科恶性肿瘤之首。与肿瘤细胞分化高度异质性相比，肿瘤间质细胞遗传性稳定，不大可能产生获得性突变而导致抗药性。本文综述了卵巢癌针对肿瘤间质的治疗策略，为恶性妇科肿瘤治疗降低毒副作用、防止复发和转移，进一步提高生存率指明了方向。
More than 80% of the patients with ovarian cancer chemotherapy relapse due to drug resistance, which makes the highest ovarian cancer mortality rates among the gynecologic malignancies. Compared with the highly heterogeneous tumor cell differentiation, tumor stroma cells have genetic stability, and it is unlikely to produce acquired mutations and lead to drug resistance. In view of the treatment strategies for tumor interstitium, ovarian cancer is reviewed in this paper. At the same time, we pointed out the direction for reducing toxicity, preventing the cancer recurrence and metastasis, improving the survival rate in the treatment of gynecologic malignancies.