标题:
蟾蝓保元汤为主治疗晚期非小细胞肺癌的队列研究
A Cohort Study on Advanced-Stage NSCLC Mainly with Chanyubaoyuan Decoction
作者:
苏尔云, 张永奎, 宋帮丽, 乐涵波, 陈志军, 张斌杰
关键字:
蟾蝓保元汤, 晚期非小细胞肺癌, 生存期, 队列研究Chanyubaoyuan Decoction, Advanced-Stage NSCLC, Survival Time, Cohort Study
期刊名称:
《Traditional Chinese Medicine》, Vol.3 No.2, 2014-05-26
摘要:
目的：探讨蟾蝓保元汤对晚期非小细胞肺癌(NSCLC)延长生存期的影响。方法：采用前瞻性队列研究，以晚期NSCLC(包括Ⅲb，Ⅳ期)患者为研究对象。蟾蝓保元汤加化疗为中西医治疗组(102例)，以同期单独用化疗为对照组(不用蟾蝓保元汤治疗，294例)，比较两组总生存期及1，2，3年生存率。同时观察两组治疗后的药物副反应。结果：中西医治疗组中数生存期14个月。1年生存率69.89%，2年生存率达43.01%，3年生存率29.78%。没有出现药物毒副作用。对照组中数生存期5个月。1年生存率17.48%，2年生存率达8.63%，3年生存率4.31%。有明显的血液毒性作用及体重减轻。结论：蟾蝓保元汤能显著延长晚期NSCLC患者的生存期。
Objective: To investigate the effect of Chanyubaoyuan decoction on the survival time for the pa- tients with advanced-stage NSCLC. Methods: A prospective cohort method was employed. The advanced-stage (stage Ⅲb and Ⅳ) NSCLC patients were recruited. Those in the Chinese-western medicine (CWM) treatment group (102 patients) were treated by Chanyubaoyuan Decoction as well as basic treatment of the chemotherapy. While those in the control group (294 patients) were treated only with basic chemotherapy during the corresponding period (2005-2010). The survival time of CWM group was compared with the control group. The adverse effects of treatment were observed simultaneously after treatment of two groups. Results: The median survival times of the CWM group and the control group were 14 months vs 5 months (P