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Burne, T.H., McGrath, J.J., Eyles, D.W., et al. (2005) Behavioural characterization of vitamin D receptor knockout mice. Behavioural Brain Research, 2, 299-308.

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  • 标题: 维生素D改善孤独症谱系障碍患儿行为Vitamin D Supplementation Improves Autistic Symptoms in a Child with Autism Spectrum Disorder

    作者: 贾飞勇, 王冰, 单玲, 徐志达, 冯俊燕, 杜琳

    关键字: 孤独症谱系障碍, 维生素D, 儿童, 环境因素Autism Spectrum Disorders, Vitamin D, Children, Environmental Factor

    期刊名称: 《Asian Case Reports in Pediatrics》, Vol.2 No.3, 2014-08-19

    摘要: 目的:近年来,研究发现维生素D不足和缺乏是引起孤独症谱系障碍的环境因素之一,本研究目的在于探讨补充维生素D治疗儿童孤独症谱系障碍的可能性。方法:对我科应用维生素D治疗的1例孤独症谱系障碍的临床资料进行了回顾性分析。结果:患儿因言语发育落后和不听指令来我科就诊,结合患儿的临床症状,根据DSM-IV标准,该患儿确诊为孤独症谱系障碍。ABC,CARS和M-CHAT-R量表用来评估患儿症状的严重程度。血清25(OH)D水平为14.3 ng/ml。给予患儿维生素D肌肉注射和口服共两个月,患儿临床症状好转,疾病严重程度减轻,血清25(OH)D水平升至51.8 ng/ml。结论:补充维生素D有可能改善孤独症谱系障碍患儿的临床症状。 Objective: Vitamin D insufficiency and deficiency is recently regarded as one of the environmental factors related with autism spectrum disorders. The aim of this paper is to investigate the possible effect of vitamin D supplementation on autistic behavioral manifestations of a child with autism spectrum disorders. Methods: The clinical data of one case with autism spectrum disorders with vitamin D supplementation in our department was retrospectively analyzed. Result: The child was referred to our department for language delay and unresponsivity to instruction. In view of his clinical manifestation, diagnosis of autism spectrum disorders was made according to DSM-IV. ABC, CARS and M-CHAT-R were used to assess the autistic severity in the clinic. Serum 25(OH) level was 14.3 ng/ml. Vitamin D3 intramuscular injection and oral administration were carried out according to protocol of our clinical trial registration. With a two-month following-up, the autistic symptoms were gradually improved according to clinical manifestation and assessment batteries. Meanwhile, Serum 25(OH) level was 51.8 ng/ml. Conclusion: Vitamin D supplementation may be effective in ameliorating the autistic behavioral problems in children with autism spectrum disorders.