标题:
AMMECR1的研究进展Research Advances of AMMECR1
作者:
周化民, 蔡成峰, 徐盟, 李光
关键字:
AMMECR1, 磷酸化, 相关蛋白, miRNAAMMECR1, Phosphorylation, Related Proteins, miRNA
期刊名称:
《Biophysics》, Vol.3 No.1, 2015-04-15
摘要:
AMMECR1是X-连锁邻近基因缺陷综合症AMME关键区域基因之一。它是一个非常古老而且保守的基因，从古细菌，细菌，酵母、线虫、果蝇到哺乳类和人，这一蛋白都有很高的同源性，应该在基本的生物学过程中执行某个重要的功能。但AMMECR1的生物学功能研究还很匮乏。本文从AMMECR1的表达、同源蛋白的晶体结构、磷酸化、功能相关蛋白、靶向AMMECR1的miRNA、AMMECR1可能的相互作用蛋白等方面进行综述，为开展AMMECR1研究的提供参考。AMMECR1 (Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis chromo-somal region gene 1) is a gene from the novel X-linked contiguous gene deletion syndrome AMME critical region. It encodes a transcript that is conserved throughout the course of evolution. There is a considerable degree of homology between the AMMECR1 proteins from different species ranging from bacteria and archaea to eukaryotes. This conservation suggests that AMMECR1 and its homologue proteins may exert essential functions in a variety of organisms. In this review, we will describe that AMMECR1 expression, crystal structure, phosphorylation, function-related proteins, miRNAs targeting to AMMECR1 and its interaction partner to promote the study of AMMECR1.