标题:
瘦素研究的最新进展和科学意义Recent Progress in the Study of Leptin and Its Scientific Significance
作者:
高文荣, 张浩, 姜文秀, 朱万龙
关键字:
瘦素, 瘦素抵抗, 瘦素受体, 信号通路, 肥胖Leptin, Leptin Resistance, Leptin Receptor, Signal Path, Obesity
期刊名称:
《Bioprocess》, Vol.4 No.1, 2014-04-25
摘要:
瘦素主要是由脂肪细胞分泌的一种蛋白质，与机体摄食、能量代谢、脂肪存储等的调控密切相关。目前，瘦素抵抗作为肥胖发生的一个重要危险因素已经得到公认，但具体清晰的作用机制仍未阐明，仅有瘦素受体突变、瘦素转运、瘦素信号抑制、血管内缺陷、转换缺陷等各种假说。全球的研究者正试图以这些假说为基础探讨肥胖的发生机制，进而攻克肥胖。本文对瘦素及其受体的基因表达和分子结构做了简单介绍，分析了瘦素参与的JAK/STAT、Ras和MAPK信号通路。重点探讨了瘦素抵抗机制的可能通路，以期对肥胖的瘦素抵抗机制研究有一定的参考意义。
Leptin is a protein mainly secreted by the lipocyte, which is related to the regulation of food intake, energy expenditure and fat storage closely. Currently, the theory that leptin resistance is a primary risk factor for obesity has been accepted widely. But the clear mechanism has not been clarified yet. The occurrence of leptin resistance may be related to some hypotheses, such as leptin receptor mutation, leptin transshipment, leptin signal suppression, vascular defects and conversion defects. The researchers from all over the world are trying to discover the mechanism based on these hypotheses and are expecting to cure the obesity completely. This review 1) briefly introduces the gene expression and the molecular structure of leptin and leptin receptor; 2) analyzes the signal transduction of leptin such as JAK/STAT, Ras and MAPK; 3) summarizes the access of leptin resistance. Maybe the work will have the certain reference value to the obesity research in the mechanisms of leptin resistance.