标题:
半乳糖修饰的海藻酸纳米载体构建及其抗肿瘤功效Fabrication of Galactosylated Alginate Nanoparticles as Drug Delivery System for Hepatocellular Carcinoma
作者:
李政雄, 吴晓盈
关键字:
肝癌, 海藻酸纳米粒, 半乳糖, 药物递送, DOXHepatocellular Carcinoma, Alginate Nanoparticle, Galactose, Drug Delivery, DOX
期刊名称:
《Hans Journal of Nanotechnology》, Vol.6 No.2, 2016-05-17
摘要:
本文设计制备肝靶向聚合物纳米粒–半乳糖(Gal)修饰海藻酸酯(HA-Gal)纳米粒，以阿霉素(DOX)为抗肿瘤模型药物制备载药纳米粒(DOX/HA-Gal)，研究DOX/HA-Gal的理化性质、载药与释药、体外细胞增殖抑制，考察不同Gal接枝比对体外抗肿瘤功效的影响。结果表明DOX/HA-Gal为大小均一的球形粒子，水合动力学粒径为180-250nm，荷负电(
The alginate derivative naonoparticles modified by galactose (HA-Gal) with various galactose (Gal) substitution degrees were synthesized to evaluate their potential for hepatocellular carcinoma (HCC) targeting. Their physicochemical characteristics were investigated. Doxorubicin hydrochloride (DOX) as a model antitumor drug was incorporated into the HA-Gal. The in vitro drug release and antitumor capability of DOX loaded HA-Gal (DOX/HA-Gal) with different Gal substitution degrees were evaluated. Negatively charged DOX/HA-Gal appeared monodisperse and spherical in shape with a size range of 180 - 250 nm, and their Zeta potentials were above 30 mV (absolute value). The size, Zeta potentials, encapsulation efficiency and in vitro cytotoxicity of HA-Gal were increased with the increment in Gal substitution degree.