标题:
基于序列关联的蛋白质亚细胞定位识别Recognition of Subcellular Localization of Proteins Using of Sequences Fusion
作者:
贾芸
关键字:
亚细胞定位, F值, 二次判别分析Subcellular Localization; F-Value; Quadratic Discriminant Analysis
期刊名称:
《Hans Journal of Computational Biology》, Vol.1 No.1, 2011-09-28
摘要:
对未知蛋白的功能注释是蛋白质组学的主要目标。一个关键的注释是蛋白质亚细胞定位的预测。应用基于序列关联的二次判别分析方法进行蛋白质亚细胞定位预测，对4个植物定位类型进行5-fold交叉检验。
Functional annotation of unknown proteins is a major goal in proteomics. A key annotation is the prediction of a protein’s subcellular localization. We used the method of Increment of Diversity with Quad-ratic Discriminant analysis (IDQD) to predict subcellular localization of proteins which are recognized by the four plant categories and three non-plant and obtained accuracy 87.4(±0.5)% and 91.2(±0.2)%, respectively in 5-fold cross-validation test. Our result is better than comparable existing methods.