Sticht, C., Freier, K., Knopfle, K., Flechtenmacher, C., Pungs, S., Hofele, C., Hahn, M., Joos, S. and Lichter, P. (2008) Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC). Neoplasia, 10, 462-470.
被以下文章引用:
-
标题:
ERK5信号通路研究现状Review of the ERK5 Signaling Pathway Research
作者:
罗松, 苏胜发, 欧阳伟炜, 卢冰
关键字:
ERK5, 信号通路, MAPKERK5, Signaling Pathways, MAPK
期刊名称:
《World Journal of Cancer Research》, Vol.4 No.4, 2014-10-31
摘要:
细胞外信号调节激酶5(extracellular signal regulated kinase, ERK5)是丝裂原活化蛋白激酶(mitogen activated protein kinase, MAPK)系统中的重要组成部分，也是MAPK信号转导通路中较新的一条通路，近几年备受人们关注。它可以被各种刺激因素激活，对细胞生存、增殖和分化有着重要作用，与血管发育、增殖等功能密切相关。本文从ERK5的来历、结构、性质、特点以及与肿瘤和非肿瘤疾病的关系，并对它以后的研究方向进行综述。Extracellular signal regulated kinase 5 (ERK5) is an important part of mitogen activated protein kinase (MAPK) system, and also is a new signal transduction pathway of MAPK signaling system, which has attracted much attention in recent years. ERK5 can be activated by many stimulating factors and plays an important role in cell survival, proliferation and differentiation. Furthermore, ERK5 is closely related to vascular development and proliferation, and other critical functions. This paper focuses on the origin, structure, property, physiological features of ERK5, and the relation-ship between ERK5 and tumor and non-oncologic diseases, and reviews the research direction in the future.