基本情况

侯鹏,现任西安交通大学第一附属医院博导、教授;陕西省肿瘤精准医学重点实验室副主任。

 

研究领域

内分泌系统肿瘤;肿瘤遗传与表观遗传学;肿瘤分子靶向治疗

 

教育背景

20019月至20048月博士,东南大学,生物医学工程学院

19989月至20017月硕士,兰州大学,生命科学学院

19949月至19987月学士,兰州大学,生命科学学院

 

工作经历

20099月至今 教授,西安交通大学第一附属医院

20059月至20098月博士后,美国约翰霍普金斯大学医学院内分泌代谢科

 

科研项目

  1. 国家自然科学基金面上项目 (2023.1-2026.12, 项目编号:82273036)
  2. 国家自然科学基金面上项目 (2021.1-2024.12, 项目编号:82072949)
  3. 国家自然科学基金面上项目 (2018.1-2021.12, 项目编号:81770787)
  4. 国家自然科学基金面上项目 (2016.1-2019.12, 项目编号:81572627)
  5. 国家自然科学基金面上项目 (2014.1-2017.12, 项目编号:81372217)
  6. 国家自然科学基金面上项目 (2012.1-2014.12, 项目编号:81171969)
  7. 国家自然科学基金青年项目 (2010.1-2012.12, 项目编号:30901459)
  8. 国家重点基础研究发展计划(973)子课题(2010.1-2014.12, 项目编号: 2010CB933903)
  9. 教育部新世纪优秀才支持计划项目 (2011.1-2013.12, 项目编号: NCET-10-0674)
  10. 教育部博士点基金(博导类)(2013.1-2015.12, 项目编号:20120201110058)
  11. 陕西省甲状腺疾病诊治创新团队(2018.1-2020.12, 项目编号:2018TD-006
  12. 陕西省重点研发计划(2019.6.1-2021.5.31, 项目编号:2019SF-015
  13. 西安交通大学自主创新能力提升计划(2018.1-2022.12, 项目编号:PY3A020
  14. 西安交通大学杰青培育项目(2010.1-2015.12, 项目编号:08143001
  15. 西安交通大学腾飞特聘教授配套经费
  16. 西安交通大学光华特聘教授配套经费

 

论文发表

近年来,共发表SCI论文200余篇,被引用超过6600H-index 42 (其中以第一及通

讯作者发表SCI论文100余篇,IF>10的论文24篇,1 篇论文入选ESI 高被引论文)

代表论著(*通讯作者;#并列第一)

  1. Yang Q, Dang H, Liu J, Wang X, Wang J, Lan X, Ji M*, Xing M*, Hou P*. Hypoxia switches TET1 from being tumor-suppressive to oncogenic. Oncogene. 2023 Apr 5
  2. Zeng Z, Zheng W, Hou P*. The role of drug-metabolizing enzymes in synthetic lethality of cancer. Pharmacol Ther. 2022 May 27;240:108219
  3. Ma S, Wang N, Liu R, Zhang R, Dang H, Wang Y, Wang S, Zeng Z, Ji M*, Hou P* ZIP10 is a negative determinant for anti-tumor effect of mannose in thyroid cancer by activating phosphate mannose isomerase. J Exp Clin Cancer Res. 2021; 40(1):387
  4. Da C, Pu J, Liu Z, Wei J, Qu Y, Wu Y, Shi B, Yang J*, He N*, Hou P*. HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells. Signal Transduct Target Ther. 2021; 6(1):399
  5. Su X, Feng C, Wang S, Shi L, Gu Q, Zhang H, Lan X, Zhao Y, Qiang W, Ji M*, Hou P*. The noncoding RNAs SNORD50A and SNORD50B-mediated TRIM21-GMPS interaction promotes the growth of p53 wild-type breast cancers by degrading p53. Cell Death Differ. 2021;28(8):2450-2464
  6. Wang S, Zhou X, Zeng Z, Sui M, Chen L, Feng C, Huang C, Yang Q, Ji M, Hou P*. Atovaquone-HSA nano-drugs enhance the efficacy of PD-1 blockade immunotherapy by improving hypoxic tumor microenvironment. J Nanobiotechnology. 2021;19(1):302
  7. Wu Y, Shi L, Zhao Y, Chen P, Cui R, Ji M, He N, Wang M*, Li G*, Hou P*. Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAF V600E-driven human cancers. NPJ Precis Oncol. 2021 Jan 22;5(1):3
  8. Bai Z, Qu Y, Shi L, Li X, Yang Z, Ji M*, Hou P*. Identification of a germline CSPG4 variation in a family with neurofibromatosis type 1-like phenotype. Cell Death Dis. 2021; 12(8):765
  9. Li Y#, Su X#, Feng C, Liu S, Guan H, Sun Y, He N*, Ji M*, Hou P*. CYP2S1 is a synthetic lethal target in BRAF V600E-driven thyroid cancers. Signal Transduct Target Ther. 2020;5(1):191
  10. He W#, Yan J#, Li Y, Yan S, Wang S, Hou P*, Lu W*. Resurrecting a p53 peptide activator - An enabling nanoengineering strategy for peptide therapeutics. J Control Release. 2020;325:293-303
  11. Li M#, Ruan B#, Wei J, Yang Q, Chen M, Ji M*, Hou P*. ACYP2 contributes to malignant progression of glioma through promoting Ca 2+ efflux and subsequently activating c-Myc and STAT3 signals. J Exp Clin Cancer Res. 2020;39(1):106
  12. Wang N, Li Y, Wei J, Pu J, Liu R, Yang Q, Guan H, Shi B, Hou P*, Ji M*. TBX1 Functions as a Tumor Suppressor in Thyroid Cancer Through Inhibiting the Activities of the PI3K/AKT and MAPK/ERK Pathways. Thyroid. 2019; 29(3):378-394
  13. Su X#, Shen Z#, Yang Q, Sui F, Pu J, Ma J, Ma S, Yao D, Ji M*, Hou P*. Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms. Theranostics. 2019; 9(15):4461-4473
  14. Yang Q, Jiang W, Hou P*. Emerging role of PI3K/AKT in tumor-related epigenetic regulation. Semin Cancer Biol. 2019;59:112-124
  15. He W#, Yan J#, Wang L, Lei B, Hou P*, Lu W*, Ma PX*. A lanthanide-peptide-derived bacterium-like nanotheranostic with high tumor-targeting, -imaging and –killing properties. Biomaterials. 2019; 206:13-24
  16. He W#, Wang S#, Yan J#, Qu Y, Jin L, Sui F, Li Y, You W, Yang G, Yang Q, Ji M, Liu M, Shao Y, Ma PX*, Lu W*, Hou P*. Self-Assembly of Therapeutic Peptide into Stimuli-Responsive Clustered Nanohybrids for Cancer-Targeted Therapy. Adv Funct Mater. 2019; 29(10):1807736
  17. Dang S, Zhou J, Chen Y, Chen P, Ji M, Shi B, Yang Q*, Hou P*. Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis. Oncogene. 2019; 38(24):4804-4819
  18. Bian Z#, Yan J#, Wang S#, Li Y, Guo Y, Ma B, Guo H, Lei Z, Yin C, Zhou Y, Liu M, Tao K*, Hou P*, He W*. Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery. Theranostics. 2018; 8(19):5320-5335
  19. Li H, Tian Z, Qu Y, Yang Q, Guan H, Shi B, Ji M*, Hou P*. SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis. Oncogene. 2019; 38(3):345-359