[1]
|
林德颖, 蔡时青. 衰老机制和衰老干预研究的近期进展和前景展望[J]. 中国医学前沿杂志(电子版), 2023, 15(10): 26-27.
|
[2]
|
Kudryashova, K.S., Burka, K., Kulaga, A.Y., Vorobyeva, N.S. and Kennedy, B.K. (2020) Aging Biomarkers: From Functional Tests to Multi-Omics Approaches. Proteomics, 20, E1900408. https://doi.org/10.1002/pmic.201900408
|
[3]
|
Gomes, A.P., Ilter, D., Low, V., Endress, J.E., Fernández-García, J., Rosenzweig, A., et al. (2020) Age-Induced Accumulation of Methylmalonic Acid Promotes Tumour Progression. Nature, 585, 283-287. https://doi.org/10.1038/s41586-020-2630-0
|
[4]
|
Tabibzadeh, S. (2021) Signaling Pathways and Effectors of Aging. Frontiers in Bioscience (Landmark Ed), 26, 50-96. https://doi.org/10.2741/4889
|
[5]
|
López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M. and Kroemer, G. (2023) Hallmarks of Aging: An Expanding Universe. Cell, 186, 243-278. https://doi.org/10.1016/j.cell.2022.11.001
|
[6]
|
Francis, R.C. (2011) Epigenetics: The Ultimate Mystery of Inheritance. W. W. Norton & Company, New York.
|
[7]
|
Rosoff, D.B., Mavromatis, L.A., Bell, A.S., Wagner, J., Jung, J., Marioni, R.E., et al. (2023) Multivariate Genome-Wide Analysis of Aging-Related Traits Identifies Novel Loci and New Drug Targets for Healthy Aging. Nature Aging, 3, 1020-1035. https://doi.org/10.1038/s43587-023-00455-5
|
[8]
|
Zhang, W., Qu, J., Liu, G.-H. and Belmonte, J.C.I. (2020) The Ageing Epigenome and Its Rejuvenation. Nature Reviews Molecular Cell Biology, 21, 137-150. https://doi.org/10.1038/s41580-019-0204-5
|
[9]
|
Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., et al. (2013) Genome-Wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates. Molecular Cell, 49, 359-367. https://doi.org/10.1016/j.molcel.2012.10.016
|
[10]
|
Horvath, S. (2013) DNA Methylation Age of Human Tissues and Cell Types. Genome Biology, 14, R115. https://doi.org/10.1186/gb-2013-14-10-r115
|
[11]
|
Benayoun, B.A., Pollina, E.A. and Brunet, A. (2015) Epigenetic Regulation of Ageing: Linking Environmental Inputs to Genomic Stability. Nature Reviews Molecular Cell Biology, 16, 593-610. https://doi.org/10.1038/nrm4048
|
[12]
|
Day, K., Waite, L.L., Thalacker-Mercer, A., West, A., Bamman, M.M., Brooks, J.D., et al. (2013) Differential DNA Methylation with Age Displays both Common and Dynamic Features across Human Tissues That Are Influenced by CpG Landscape. Genome Biology, 14, R102. https://doi.org/10.1186/gb-2013-14-9-r102
|
[13]
|
Greer, E.L. and Shi, Y. (2012) Histone Methylation: A Dynamic Mark in Health, Disease and Inheritance. Nature Reviews Genetics, 13, 343-357. https://doi.org/10.1038/nrg3173
|
[14]
|
Zhang, B., Long, Q., Wu, S., Xu, Q., Song, S., Han, L., et al. (2021) KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype. Nature Aging, 1, 454-472. https://doi.org/10.1038/s43587-021-00063-1
|
[15]
|
Lu, J.Y., Simon, M., Zhao, Y., Ablaeva, J., Corson, N., Choi, Y., et al. (2022) Comparative Transcriptomics Reveals Circadian and Pluripotency Networks as Two Pillars of Longevity Regulation. Cell Metabolism, 34, 836-856.E5. https://doi.org/10.1016/j.cmet.2022.04.011
|
[16]
|
Zou, Z., Long, X., Zhao, Q., Zheng, Y., Song, M., Ma, S., et al. (2021) A Single-Cell Transcriptomic Atlas of Human Skin Aging. Developmental Cell, 56, 383-397.E8. https://doi.org/10.1016/j.devcel.2020.11.002
|
[17]
|
The Tabula Muris Consortium (2020) A Single-Cell Transcriptomic Atlas Characterizes Ageing Tissues in the Mouse. Nature, 583, 590-595.
|
[18]
|
Gyenis, A., Chang, J., Demmers, J., Bruens, S.T., Barnhoorn, S., Brandt, R.M.C., et al. (2023) Genome-Wide RNA Polymerase Stalling Shapes the Transcriptome during Aging. Nature Genetics, 55, 268-279. https://doi.org/10.1038/s41588-022-01279-6
|
[19]
|
Wasinger, V.C., Cordwell, S.J., Cerpa-Poljak, A., Yan, J.X., Gooley, A.A., Wilkins, M.R., et al. (1995) Progress with Gene-Product Mapping of the Mollicutes: Mycoplasma Genitalium. Electrophoresis, 16, 1090-1094. https://doi.org/10.1002/elps.11501601185
|
[20]
|
Sebastiani, P., Federico, A., Morris, M., Gurinovich, A., Tanaka, T., Chandler, K.B., et al. (2021) Protein Signatures of Centenarians and Their Offspring Suggest Centenarians Age Slower than Other Humans. Aging Cell, 20, E13290. https://doi.org/10.1111/acel.13290
|
[21]
|
Liu, X., Pan, S., Xanthakis, V., Vasan, R.S., Psaty, B.M., Austin, T.R., et al. (2022) Plasma Proteomic Signature of Decline in Gait Speed and Grip Strength. Aging Cell, 21, E13736. https://doi.org/10.1111/acel.13736
|
[22]
|
Iijima, H., Gilmer, G., Wang, K., Bean, A.C., He, Y., Lin, H., et al. (2023) Age-Related Matrix Stiffening Epigenetically Regulates α-Klotho Expression and Compromises Chondrocyte Integrity. Nature Communications, 14, Article No. 18. https://doi.org/10.1038/s41467-022-35359-2
|
[23]
|
Wang, L., Cai, J., Zhao, X., Ma, L., Zeng, P., Zhou, L., et al. (2023) Palmitoylation Prevents Sustained Inflammation by Limiting NLRP3 Inflammasome Activation through Chaperone-Mediated Autophagy. Molecular Cell, 83, 281-297.E10. https://doi.org/10.1016/j.molcel.2022.12.002
|
[24]
|
Yang, S., Jin, S., Xian, H., Zhao, Z., Wang, L., Wu, Y., et al. (2023) Metabolic Enzyme UAP1 Mediates IRF3 Pyrophosphorylation to Facilitate Innate Immune Response. Molecular Cell, 83, 298-313.E8. https://doi.org/10.1016/j.molcel.2022.12.007
|
[25]
|
Koyuncu, S., Loureiro, R., Lee, H.J., Wagle, P., Krueger, M. and Vilchez, D. (2021) Rewiring of the Ubiquitinated Proteome Determines Ageing in C. elegans. Nature, 596, 285-290. https://doi.org/10.1038/s41586-021-03781-z
|
[26]
|
Li, C.J., Xiao, Y., Sun, Y.C., He, W.Z., Liu, L., Huang, M., et al. (2021) Senescent Immune Cells Release Grancalcin to Promote Skeletal Aging. Cell Metabolism, 33, 1957-1973.E6. https://doi.org/10.1016/j.cmet.2021.08.009
|
[27]
|
Lin, T., Yang, W.Q., Luo, W.W., Zhang, L.L., Mai, Y.Q., Li, Z.Q., et al. (2022) Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification. Oxidative Medicine and Cellular Longevity, 2022, Article ID: 1198607. https://doi.org/10.1155/2022/1198607
|
[28]
|
Yu, Z., Zhai, G., Singmann, P., He, Y., Xu, T., Prehn, C., et al. (2012) Human Serum Metabolic Profiles Are Age Dependent. Aging Cell, 11, 960-967. https://doi.org/10.1111/j.1474-9726.2012.00865.x
|
[29]
|
Panyard, D.J., Yu, B. and Snyder, M.P. (2022) The Metabolomics of Human Aging: Advances, Challenges, and Opportunities. Science Advances, 8, Eadd6155. https://doi.org/10.1126/sciadv.add6155
|
[30]
|
Menni, C., Kastenmüller, G., Petersen, A.K., Bell, J.T., Psatha, M., Tsai, P.C., et al. (2013) Metabolomic Markers Reveal Novel Pathways of Ageing and Early Development in Human Populations. International Journal of Epidemiology, 42, 1111-1119. https://doi.org/10.1093/ije/dyt094
|
[31]
|
Ding, J., Ji, J., Rabow, Z., Shen, T., Folz, J., Brydges, C.R., et al. (2021) A Metabolome Atlas of the Aging Mouse Brain. Nature Communications, 12, Article No. 6021. https://doi.org/10.1038/s41467-021-26310-y
|
[32]
|
Castro, A., Signini, É.F., De Oliveira, J.M., Di Medeiros Leal, M.C.B., Rehder-Santos, P., Millan-Mattos, J.C., et al. (2022) The Aging Process: A Metabolomics Perspective. Molecules, 27, Article No. 8656. https://doi.org/10.3390/molecules27248656
|
[33]
|
Srivastava, S. (2019) Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics. Metabolites, 9, Article No. 301. https://doi.org/10.3390/metabo9120301
|
[34]
|
Houtkooper, R.H., Argmann, C., Houten, S.M., Cantó, C., Jeninga, E.H., Andreux, P.A., et al. (2011) The Metabolic Footprint of Aging in Mice. Scientific Reports, 1, Article No. 134. https://doi.org/10.1038/srep00134
|
[35]
|
Benjamin, D.I., Brett, J.O., Both, P., Benjamin, J.S., Ishak, H.L., Kang, J., et al. (2023) Multiomics Reveals Glutathione Metabolism as a Driver of Bimodality during Stem Cell Aging. Cell Metabolism, 35, 472-486.E6. https://doi.org/10.1016/j.cmet.2023.02.001
|
[36]
|
Li, J., Xiong, M., Fu, X.H., Fan, Y., Dong, C., Sun, X., et al. (2023) Determining a Multimodal Aging Clock in a Cohort of Chinese Women. Med, 4, 825-848.E13. https://doi.org/10.1016/j.medj.2023.06.010
|
[37]
|
Wu, L., Xie, X., Liang, T., Ma, J., Yang, L., Yang, J., et al. (2021) Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets. Biomolecules, 12, Article No. 39. https://doi.org/10.3390/biom12010039
|