基本情况
张应玖,博士,吉林大学吉林大学分子酶学工程教育部重点实验室教授、博士生导师。中国药理学会抗衰老和老年痴呆专业委员会委员,吉林省生物化学与分子生物学会常务理事,吉林省细胞生物学会理事。先后主持或参与国家“863”课题、国家自然科学基金、吉林省科技厅研究项目等共10余项;已在Nature等国内外学术刊物上公开发表学术论文80余篇,参编著作多部,获省级科技进步一等奖一项。
研究领域
基因表达与调控、多功能淀粉酶等的催化机理研究、神经退行性疾病发生的分子机制、神经退行性疾病的预防与治疗、神经细胞骨架蛋白的结构与功能研究、肿瘤的发生与凋亡
教育背景
2001年 博士,吉林大学
1988年 硕士,吉林大学
1985年 学士,吉林大学
科研项目
主持国家863计划项目子课题一项
主持国家自然基金面上项目一项
主持教育部留学人员回国启动基金一项
主持省科技厅项目多项
论文发表
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Fan Li, Xuejun Zhu, Yanfei Li, Hao Cao, and Yingjiu Zhang*. Functional characterization of a special thermophilic multifunctional amylase OPMA-N and its N-terminal domain. Acta Biochim Biophys Sin. 2011, 43(4): 324–334
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WANG Jia-peng, CUI Li-li, HUANG Xue-mei and ZHANG Ying-jiu*. Aβ28-Induced Specific and Effective Serum Antibodies Against Aβ42. CHEM. RES. CHINESE UNIVERSITIES 2010, 26(6), 974-980
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Li X, Zhang Y, Xie P, Piao J, Hu Y, Chang M, Liu T, Hu L. Proteomic characterization of an isolated fraction ofsynthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI. BMC Neurosci. 2010, 11
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Lili Cui, Xuemei Huang, Jiapeng Wang, Yingjiu Zhang*. Specific and efficient anti-Aβ42 antibodies induced by sixteen tandem repeats of Aβ9. Journal of Neuroimmunology. J Neuroimmunol. 2010, 227(1-2): 18-25
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Yang Wang, Fan Li, Yingjiu Zhang*. Preliminary Investigation on the Action Modes of an Oligosaccharide-Producing Multifunctional Amylase. Appl Biochem Biotechnol. 2010, 160(7): 1955-1966
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Xuemei Huang, Jiapeng Wang, Lili Cui, Xiaohuan Zou, Yingjiu Zhang*. Recombinant GST-I-Aβ28-induced efficient serum antibody against Aβ42. J Neurosci Methods. 2010, 186: 52-59
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Wang, Y. Li, F. Gao, CH. Zhang, YJ*. Characterization of a novel mesophilic bacterial amylase secreted by ZW2531-1, A strain newly isolated from soil. Chem Res Chinese U. 2009, 25(2): 198-202
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XU Guang-wei, WANG Jia-peng, HUANG Xue-mei, ZHANG Ying-jiu*. Expression characterization and preparation of human amyloid precursor protein in Escherichia coli. Chem. Res. Chinese U. 2009, 25(1): 64-68
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ILKAP在肿瘤发生发展中的作用(中国生物化学与分子生物学报 2009-6)
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治疗阿尔茨海默病的早老素/γ-分泌酶抑制剂和调节剂(生命科学 2009-4)
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淀粉样前体蛋白(APP)相互作用及其生物学意义(生命科学 2009-2)
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α-淀粉酶家族的新成员——多功能淀粉酶(中国生物化学与分子生物学报 2009-2)
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蛋白磷酸酶2C(PP2C)的表达、纯化与催化活性(吉林大学学报:理学版 2009-1)
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Xing'an Li, Yingjiu Zhang, Yihong Hu, Ming Chang, Tao Liu, Danping Wang, Yu Zhang, Lei Zhang and Linsen Hu.Chaperone proteins identified from synthetic proteasome inhibitor-induced inclusions in PC12 cells by proteomic analysis. Acta Biochimica et Biophysica Sinica. 2008, 40 (5): 406–418
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LI Xing-An, ZHANG Ying-Jiu, HU Yi-Hong, CHANG Ming, LIU Tao, WANG DAN-Ping, ZHANG Lei, ZHANG Yu, HU Lin-Sen. Protein components of lewy bodies (LBs)identified from synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells by MS analysis. 2008, 24(10): 906-915
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LI Xing-An, ZHANG Ying-Jiu, HU Yi-Hong, CHANG Ming, LIU Tao, WANG DAN-Ping, ZHANG Lei, ZHANG Yu, HU Lin-Sen. Eukaryotic Translation Factors Resided in PSI-induced Inclusions in PC12. 2008, 24(1):20-29
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免疫治疗阿尔茨海默病的研究及其意义(中国神经免疫学和神经病学杂志 2008-5)
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一株产新型淀粉酶的嗜温菌ZW2531-1的分离与鉴定(吉林大学学报:理学版 2008-4)
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Wang Y, Zhang Y, Ha Y. Crystal structure of a rhomboid family intramembrane protease. Nature. 2006, 444(7116): 179-183
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Zhao B, Jin NY, Wang RL, Zhang LS, Zhang YJ*. Immunization of mice with a DNA vaccine based on severe acute respiratory syndrome coronavirus spike protein fragment 1. Viral Immunol. 2006, 19(3): 518-24
专利
肿瘤细胞核靶向药物载体及其在制备抗肿瘤药物中的应用(专利号:201010605363.X)
高效细胞核靶向药物载体及其在制备抗肿瘤药物中的应用(专利号:201010605376.7)
抗HIV-1外膜蛋白的单链抗体及重组免疫毒素(专利号:CN76948C)
一种用于治疗老年痴呆症的重组抗原多肽及多肽基因(专利号:200910066499.5)
一种用于治疗阿尔茨海默氏病的抗原蛋白及蛋白基因(专利号:200910066564.4)
嗜温多功能淀粉酶基因和嗜温多功能淀粉酶及其应用(专利号:200910067210.1)