Z-DNA与人类疾病
Z-DNA and Human Diseases
DOI: 10.12677/HJBM.2014.42003, PDF, HTML, 下载: 4,056  浏览: 14,383  国家自然科学基金支持
作者: 周文琪, 陈诗哲, 马天骏：南方医科大学第一临床医学院八年制，广州；李金明, 郭艳芳：南方医科大学基础医学院生物信息学系，广州
关键词: Z-DNA；Z-DNA结合蛋白；人类疾病；基因调控；Z-DNA； Z-DNA Binding Protein； Human Disease； Gene Regulation
摘要: Z-DNA在1979年被Rich等人发现，它处于高能状态而不稳定，不同于传统的B-DNA，Z-DNA以其特殊的构象和重要生物学功能越来越受到人们关注，与其作用相关的Z-DNA结合蛋白也备受关注。Z-DNA有其特殊的序列和形成条件，其重要生物学功能也逐渐被揭开面纱，在基因调控、肿瘤发生与病毒感染中都有重要作用。
Abstract: Z-DNA structure was found by Rich et al. in 1979. Being different from the common B-DNA structure, Z-DNA has its own special conformation and biological functions, and the research on Z-DNA arrests more and more attentions in the recent years. It has been reported that Z-DNA plays important roles in gene regulation, tumor pathogenesis and viral infections.
文章引用：周文琪, 陈诗哲, 马天骏, 李金明, 郭艳芳. Z-DNA与人类疾病[J]. 生物医学, 2014, 4(2): 17-21. http://dx.doi.org/10.12677/HJBM.2014.42003

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