WJCR  >> Vol. 4 No. 3 (July 2014)

    胃食管反流病与恶性肿瘤化疗关系的探讨
    Relation between Gastroesophageal Reflux Disease and Malignant Tumor Chemotherapy

  • 全文下载: PDF(407KB) HTML    PP.33-39   DOI: 10.12677/WJCR.2014.43007  
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作者:  

刘汉山:武警江苏总队医院消化内科,扬州;
朱海杭:扬州大学医学院临床学院消化内科,扬州

关键词:
胃食管反流病恶性肿瘤化疗关系Gastroesophageal Reflux Disease Malignant Tumor Chemotherapy Relationship

摘要:

目的:探讨胃食管反流病(GERD)和恶性肿瘤化疗的关系,以及质子泵抑制剂(PPI)在化疗诱导的GERD中的疗效。方法:于2013年1月~2013年12月期间连续征集有化疗适应症的住院的恶性肿瘤患者200例,采用前瞻性研究方法,随机分为化疗组(A组),化疗 + PPI组(B组),两组各100例。采用反流性疾病调查问卷(RDQ)评分,总分≥12分者临床诊断为GERD,分别比较两组化疗前后RDQ总分变化、GERD发生率。结果:化疗前A组有7例、B组有7例RDQ总分≥12分,化疗后A组有32例、B组有10例RDQ总分≥12分,分别增加了25例、3例。化疗前后RDQ均分分别为A组5.96 ± 3.08/10.99 ± 4.19、B组6.74 ± 2.91/7.89 ± 2.43,化疗前后GERD发生率分别为A组7.61%/34.78%、B组7.45%/10.64%。比较化疗前后RDQ均分变化、GERD发生率,A组有显著性差异(P < 0.05),B组无显著性差异(P > 0.05),两组间比较具有差异显著性(P < 0.05),提示GERD与化疗有明显相关性,化疗同时使用PPI制剂能明显改善RDQ评分及GERD发生率。结论:恶性肿瘤化疗诱导的GERD发生率明显增高,化疗同时使用PPI有助于缓解化疗相关GERD症状,减轻化疗相关不良反应,改善恶性肿瘤患者生活质量。
 Objective: To explore the relationship between gastroesophageal reflux disease (GERD) and malignant tumor chemotherapy, as well as the efficacy of proton pump inhibitor (PPI) omeprazol enteric-coated tablet in chemotherapy-induced GERD. Methods: Malignant tumor patients who received chemotherapy were recruited in this study from January 2013 to December 2013. All patients were randomly divided into chemotherapy group (group A, n = 100) and chemotherapy + PPI group (group B, n = 100). According to reflux disease questionnaire (RDQ) score, the RDQ score changes of two groups were collected before and after chemotherapy. Patients with the RDQ total score ≥12 points were diagnosed with GERD. The change of GERD incidence and RDQ mean score was compared in the two groups before and after chemotherapy, respectively. Results: Before chemotherapy, there were 7 patients in group A and 7 patients in group B whose RDQ total score was ≥12 points, while 32 patients in group A and 10 patients in group B after chemotherapy. The RDQ mean score before and after chemotherapy was 5.96 ± 3.08/10.99 ± 4.19 in group A and 6.74 ± 2.91/7.89 ± 2.43 ingroup B. GERD incidence before and after chemotherapy was 7.61%/34.78% in group A and 7.45%/10.64% in group B. There was a significant difference (P < 0.05) of the change of the RDQ mean score and GERD incidence in group A, but, there was no significant difference in group B (P > 0.05). The study indicated that GERD was significantly associated with chemotherapy. Chemotherapy combined with PPI could evidently reduce the RDQ total score and GERD incidence. Conclusions: Patients who received chemotherapy had a significantly higher incidence of GERD, and PPI could relieve GERD symptoms, reduce chemotherapy-related adverse reactions, and improve the quality of life of malignant tumor patients.

文章引用:
刘汉山, 朱海杭. 胃食管反流病与恶性肿瘤化疗关系的探讨[J]. 世界肿瘤研究, 2014, 4(3): 33-39. http://dx.doi.org/10.12677/WJCR.2014.43007

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