[1]
|
Amly, W. and Karaman, R. (2016) Recent Updates in Utilizing Targeted Prodrugs in Drug Delivery (2013-2015). Expert Opinion on Drug Delivery, 13, 571-591.
|
[2]
|
王晓洁. 前药设计理念在药物载体中的应用[J]. 中国处方药, 2016, 14(8): 13-14.
|
[3]
|
刘丰华, 郭惠娟, 王莉. 维生素C的药理与临床应用[J]. 亚太传统医药, 2010, 6(3): 89-90.
|
[4]
|
Savini, I., Rossi, A., Pierro, C., et al. (2008) SVCT1 and SVCT2: Key Proteins for Vitamin C Uptake. Amino Acids, 34, 347-355. https://doi.org/10.1007/s00726-007-0555-7
|
[5]
|
Corti, A., Casini, A.F. and Pompella, A. (2010) Cellular Pathways for Transport and Efflux of Ascorbate and Dehydroascorbate. Archives of Biochemistry & Biophysics, 500, 107-115.
|
[6]
|
Cai, Y., Zhai, J.J., Feng, B.B., et al. (2014) Expression of Glucose Transporter Protein 1 and p63 in Serous Ovarian Tumor. Journal of Obstetrics and Gynaecology Research, 40, 1925-1930. https://doi.org/10.1111/jog.12447
|
[7]
|
燕玉娥. 朊病毒感染后葡萄糖转运体与葡萄糖摄取能力的变化及其机制初探[D]: [硕士学位论文]. 西安: 第四军医大学, 2014.
|
[8]
|
李爱梅, 孙一文, 贾鹏, 郭万华. 肝细胞源性肝癌PET-CT成像标准摄取值与葡萄糖转运蛋白1的关系[J]. 东南国防医药, 2015, 17(6): 572-574.
|
[9]
|
王丽娜, 王丽娟, 胡振芳, 等. 丁苯酞联合依达拉奉对局灶性脑梗死大鼠皮质血脑屏障及咬合蛋白表达的影响[J]. 河北医科大学学报, 2016, 37(4): 385-388.
|
[10]
|
Pavan, B., Dalpiaz, A., Ciliberti, N., et al. (2008) Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach. Molecules, 13, 1035-1065. https://doi.org/10.3390/molecules13051035
|
[11]
|
Manfredini, S. (2002) Prodrugs Derivatives of the Ascorbic Acid Suitable to the Passage of the Hematoencephalic Barrier: WO, WO 2002070499 A2.
|
[12]
|
Tang, L., Dai, A., Wang, Z., et al. (2012) Ascorbic Acid Aryl Acetate/Propionate Ester, Preparation Method and Pharmaceutical Composition Thereof: EP, EP 2431361 A1.
|
[13]
|
Zhao, Y., Qu, B., Wu, X., et al. (2014) Design, Synthesis and Biological Evaluation of Brain Targeting l-Ascorbic Acid Prodrugs of Ibuprofen with “Lock-In” Function. European Journal of Medicinal Chemistry, 82, 314-323.
|
[14]
|
Wu, X.Y., Li, X.C., Mi, J., et al. (2013) Design, Synthesis and Preliminary Biological Evaluation of Brain Targeting L-Ascorbic Acid Prodrugs of Ibuprofen. Chinese Chemical Letters, 24, 117-119.
|
[15]
|
Xie, Y. (2014) Preparation, Transportation Mechanisms and Brain-Targeting Evaluation of a Chemical Delivery System Exploiting the Blood-Cerebrospinal Fluid Barrier. Journal of Drug Targeting, 22, 724-731.
https://doi.org/10.3109/1061186X.2014.915551
|
[16]
|
Laras, Y., Sheha, M., Pietrancosta, N., et al. (2007) Thiazola-mide-Ascorbic Acid Conjugate: A γ-Secretase Inhibitor with Enhanced Blood-Brain Barrier Permeation. Australian Journal of Chemistry, 60, 128-132.
https://doi.org/10.1071/CH06441
|
[17]
|
Luo, S., Wang, Z., Patel, M., et al. (2011) Targeting SVCT for Enhanced Drug Absorption: Synthesis and in Vitro Evaluation of a Novel Vitamin C Conjugated Prodrug of Saquinavir. International Journal of Pharmaceutics, 414, 77-85.
|
[18]
|
Manfredini, S., Vertuani, S., Pavan, B., et al. (2004) Design, Synthesis and in Vitro Evaluation on HRPE Cells of Ascorbic and 6-Bromoascorbic Acid Conjugates with Neuroactive Molecules. Bioorganic & Medicinal Chemistry, 12, 5453-5463.
|
[19]
|
Dalpiaz, A., Pavan, B., Vertuani, S., et al. (2005) Ascorbic and 6-Br-Ascorbic Acid Conjugates as a Tool to Increase the Therapeutic Effects of Potentially Central Active Drugs. European Journal of Pharmaceutical Sciences, 24, 259- 269.
|
[20]
|
Corpe, C.P., Lee, J.H., Kwon, O., et al. (2005) 6-Bromo-6-deoxy-L-ascorbic Acid: An Ascorbate Analog Specific for Na+-Dependent Vitamin C Transporter but Not Glucose Transporter Pathways. Journal of Biological Chemistry, 280, 5211-5220. https://doi.org/10.1074/jbc.M412925200
|
[21]
|
Shao, K., Yu, Z., Ning, D., et al. (2014) Functionalized Nanoscale Micelles with Brain Targeting Ability and Intercellular Microenvironment Biosensitivity for Anti-Intracranial Infection Applications. Advanced Healthcare Materials, 4, 291-300.
https://doi.org/10.1002/adhm.201400214
|
[22]
|
Guo, Y., Zhang, Y., Li, J., et al. (2015) Cell Microenvironment-Controlled Antitumor Drug Releasing-Nanomicelles for GLUT1-Targeting Hepatocellular Carcinoma Therapy. ACS Applied Materials & Interfaces, 7, 5444-5453.
https://doi.org/10.1021/am5091462
|
[23]
|
陈鹏. 维生素C为亲水片断的脑靶向药物载体的合成研究[D]: [硕士学位论文]. 北京: 北京化工大学, 2010.
|
[24]
|
杨晶, 刘亦江. 一种具有脑-靶向性的高分子药物输送材料及其制备方法[P]. CN102250298A, 2011.
|
[25]
|
Kesinger, N.G. (2009) Ascorbylation—The Biological Relevance of Covalently Bound Ascorbic Acid. Acrolein.
|
[26]
|
王艳斋. 聚维生素C丙烯酸酯为亲水片段的药物载体的合成与性质研究[D]: [硕士学位论文] . 北京: 北京化工大学, 2012.
|