IJPN  >> Vol. 6 No. 3 (August 2017)

作者:  

张文芳:滨州医学院,山东 烟台;
闫海静,杨 志:滨州医学院代谢与神经精神疾病研究所,山东 烟台;
王 东:滨州医学院烟台附院,山东 烟台

关键词:
DHA脂肪酸保健品神经系统阿尔茨海默病抑郁症DHA Fatty Acids Health Products Nervous System Alzheimer’s Disease Depression

摘要:

目的:目前市场上出售的保健品种类繁多,我们如何选择一种无副作用还能对疾病起到预防作用的保健品呢?DHA (ω-3:7,10,13,16,19-二十二碳六烯酸)作为一种多不饱和脂肪酸,能够通过血脑屏障,是大脑皮层神经元细胞膜的形成的重要原料;改善人类认知功能,减轻阿尔茨海默病和抑郁症的发生;方法:本文把近年来国外对DHA的研究情况作了系统综述。结果与结论:DHA的开发利用己受到世界各国的关注和重视。DHA能够预防和改善精神疾病和神经退行性病变。选择DHA作为一种保健品,不失为一种明智的选择。

Various health products are sold on the market at present. How can we choose a health product which has no side effects and a wholesome product on disease? DHA (omega-3:7, 10, 13, 16, 19-docosahexaenoic acid) as a kind of polyunsaturated fatty acids, can across the blood-brain barrier, which are the important raw material for the formation of cerebral cortex neuron membrane and could improve human cognitive function and reduce the occurrence of Alzheimer's disease and depression. Method: This paper summarizes the research of DHA in foreign countries in recent years. Result and Conclusion: The development and utilization of DHA has been paid attention and concerned by all countries in the world. DHA can prevent and improve mental illnesses and neurodegenerative diseases. Choosing DHA as a health supplement is a wise choice.

文章引用:
张文芳, 闫海静, 杨志, 王东. DHA,吃还是不吃?[J]. 国际神经精神科学杂志, 2017, 6(3): 50-55. https://doi.org/10.12677/IJPN.2017.63009

参考文献

[1] Cruciani-Guglielmacci, C. and Magnan, C. (2017) Brain Lipoprotein Lipase as a Regulator of Energy Balance. Biochimie.
https://doi.org/10.1016/j.biochi.2017.07.012
[2] Sun, G.Y., Simonyi, A., Fritsche, K.L., et al. (2017) Docosahexaenoic acid (DHA): An Essential Nutrient and a Nutraceutical for Brain Health and Diseases. Prostaglandins, Leukotrienes, and Essential Fatty Acids.
https://doi.org/10.1016/j.plefa.2017.03.006
[3] Cardoso, C., Afonso, C. and Bandarra, N.M. (2016) Dietary DHA and Health: Cognitive Function Ageing. Nutrition Research Reviews, 29, 281-294.
https://doi.org/10.1017/S0954422416000184
[4] Lo Van, A., Sakayori, N., Hachem, M., et al. (2016) Mechanisms of DHA Transport to the Brain and Potential Therapy to Neurodegenerative Diseases. Biochimie, 130, 163-167.
https://doi.org/10.1016/j.biochi.2016.07.011
[5] Skjevik, A.A., Madej, B.D., Dickson, C.J., et al. (2016) Simulation of Lipid Bilayer Self-Assembly Using All-Atom Lipid Force Fields. Physical Chemistry Chemical Physics: PCCP, 18, 10573-10584.
https://doi.org/10.1039/C5CP07379K
[6] Soussi, J. and Chalopin, Y. (2015) Electric Polarizability of Lipid Bilayers: The Influence of the Structure. The Journal of Chemical Physics, 143, 144904.
https://doi.org/10.1063/1.4932340
[7] Kong, X., Lu, D., Wu, J. and Liu, Z. (2016) Spreading of a Unilamellar Liposome on Charged Substrates: A Coarse-Grained Molecular Simulation. Langmuir: The ACS Journal of Surfaces and Colloids, 32, 3785-3793.
https://doi.org/10.1021/acs.langmuir.6b00043
[8] Pomponi, M.F., Gambassi, G., Pomponi, M. and Masullo, C. (2010) Alzheimer’s Disease: Fatty Acids We Eat May Be Linked to a Specific Protection via Low-Dose Aspirin. Aging and Disease, 1, 37-59.
[9] Yang, X., Sheng, W., Sun, G.Y. and Lee, J.C. (2011) Effects of Fatty Acid Unsaturation Numbers on Membrane Fluidity and Alpha-Secretase-Dependent Amyloid Precursor Protein Processing. Neurochemistry International, 58, 321-329.
https://doi.org/10.1016/j.neuint.2010.12.004
[10] Amiri-Jami, M., Abdelhamid, A.G., Hazaa, M., Kakuda, Y. and Griffths, M.W. (2015) Recombinant Production of Omega-3 Fatty Acids by Probiotic Escherichia coli Nissle 1917. FEMS Microbiology Letters, 362.
https://doi.org/10.1093/femsle/fnv166
[11] Ghasemifard, S., Hermon, K., Turchini, G.M. and Sinclair, A.J. (2015) Metabolic Fate (Absorption, Beta-Oxidation and Deposition) of Long-Chain n-3 Fatty Acids Is Affected by Sex and by the Oil Source (Krill Oil or Fish Oil) in the Rat. The British Journal of Nutrition, 114, 684-692.
https://doi.org/10.1017/S0007114515002457
[12] Rincon-Cervera, M.A., Valenzuela, R., Hernandez-Rodas, M.C., et al. (2016) Vegetable Oils Rich in Alpha Linolenic Acid Increment Hepatic n-3 LCPUFA, Modulating the Fatty Acid Metabolism and Antioxidant Response in Rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 111, 25-35.
[13] Kuda, O. (2017) Bioactive Metabolites of Docosahexaenoic Acid. Biochimie, 136, 12-20.
[14] Petrie, J.R., Shrestha, P., Belide, S., et al. (2014) Metabolic Engineering Camelina sativa with Fish Oil-Like Levels of DHA. PLoS ONE, 9, e85061.
https://doi.org/10.1371/journal.pone.0085061
[15] Cansev, M., Wurtman, R.J., Sakamoto, T. and Ulus, I.H. (2008) Oral Administration of Circulating Precursors for Membrane Phosphatides Can Promote the Synthesis of New Brain Synapses. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 4, S153-S168.
[16] Schwanke, R.C., Marcon, R., Bento, A.F. and Calixto, J.B. (2016) EPA- and DHA-Derived Resolvins’ Actions in Inflammatory Bowel Disease. European Journal of Pharmacology, 785, 156-164.
[17] Song, C., Shieh, C.H., Wu, Y.S., Kalueff, A., Gaikwad, S. and Su, K.P. (2016) The Role of Omega-3 Polyunsaturated Fatty Acids Eicosapentaenoic and Docosahexaenoic Acids in the Treatment of Major Depression and Alzheimer’s Disease: Acting Separately or Synergistically? Progress in Lipid Research, 62, 41-54.
[18] Wang, Y., Botelho, A.V., Martinez, G.V. and Brown, M.F. (2002) Electrostatic Properties of Membrane Lipids Coupled to Metarhodopsin II Formation in Visual Transduction. Journal of the American Chemical Society, 124, 7690-7701.
https://doi.org/10.1021/ja0200488
[19] Grimm, M.O., Zimmer, V.C., Lehmann, J., Grimm, H.S. and Hartmann, T. (2013) The Impact of Cholesterol, DHA, and Sphingolipids on Alzheimer’s Disease. BioMed Research International, 2013, Article ID: 814390.
https://doi.org/10.1155/2013/814390
[20] Treen, M., Uauy, R.D., Jameson, D.M., et al. (1992) Effect of Docosahexaenoic Acid on Membrane Fluidity and Function in Intact Cultured Y-79 Retinoblastoma Cells. Archives of Biochemistry and Biophysics, 294, 564-570.
[21] Hashimoto, M., Hossain, S. and Shido, O. (2006) Docosahexaenoic Acid but Not Eicosapentaenoic Acid Withstands Dietary Cholesterol-Induced Decreases in Platelet Membrane Fluidity. Molecular and Cellular Biochemistry, 293, 1-8.
https://doi.org/10.1007/s11010-006-0164-x
[22] Czlonkowska, A. and Kurkowska-Jastrzebska, I. (2011) Inflammation and Gliosis in Neurological Diseases—Clinical Implications. Journal of Neuroimmunology, 231, 78-85.
[23] Salem, N., Vandal, M. and Calon, F. (2015) The Benefit of Docosahexaenoic Acid for the Adult Brain in Aging and Dementia. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 92, 15-22.
[24] Yamashita, S., Kiko, T., Fujiwara, H., et al. (2016) Alterations in the Levels of Amyloid-Beta, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer’s Disease: Possible Interactions between Amyloid-Beta and These Lipids. Journal of Alzheimer’s Disease, 50, 527-537.
https://doi.org/10.3233/JAD-150640
[25] Yassine, H.N., Feng, Q., Azizkhanian, I., et al. (2016) Association of Serum Docosahexaenoic Acid with Cerebral Amyloidosis. JAMA Neurology, 73, 1208-1216.
https://doi.org/10.1001/jamaneurol.2016.1924
[26] Yassine, H.N., Rawat, V., Mack, W.J., et al. (2016) The Effect of APOE Genotype on the Delivery of DHA to Cerebrospinal Fluid in Alzheimer’s Disease. Alzheimer’s Research & Therapy, 8, 25.
https://doi.org/10.1186/s13195-016-0194-x
[27] Bahety, P., Van Nguyen, T.H., Hong, Y., Zhang, L., Chan, E.C. and Ee, P.L. (2017) Understanding the Cholesterol Metabolism-Perturbing Effects of Docosahexaenoic Acid by Gas Chromatography-Mass Spectrometry Targeted Metabonomic Profiling. European Journal of Nutrition, 56, 29-43.
https://doi.org/10.1007/s00394-015-1053-4
[28] Zhang, Y., Chen, J., Qiu, J., Li, Y., Wang, J. and Jiao, J. (2016) Intakes of Fish and Polyunsaturated Fatty Acids and Mild-to-Severe Cognitive Impairment Risks: A Dose-Response Me-ta-Analysis of 21 Cohort Studies. The American Journal of Clinical Nutrition, 103, 330-340.
https://doi.org/10.3945/ajcn.115.124081
[29] De Souza Fernandes, D.P., Canaan Rezende, F.A., Pereira Rocha, G., De Santis Filgueiras, M., Silva Moreira, P.R. and Goncalves Alfenas Rde, C. (2015) Effect of Eicosapentaenoic Acid and Docosahexaenoic Acid Supplementations to Control Cognitive Decline in Dementia and Alzheimer’s Disease: A Systematic Review. Nutricion Hospitalaria, 32, 528-533.
[30] Leduc, V., Jasmin-Belanger, S. and Poirier, J. (2010) APOE and Cholesterol Homeostasis in Alzheimer’s Disease. Trends in Molecular Medicine, 16, 469-477.
[31] Sastry, P.S. (1985) Lipids of Nervous Tissue: Composition and Metabolism. Progress in Lipid Research, 24, 69-176.
[32] Calderon, F. (2007) Role of RXR in Neurite Outgrowth Induced by Docosahexaenoic Acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77, 227-232.
[33] Darios, F. and Davletov, B. (2006) Omega-3 and Omega-6 Fatty Acids Stimulate Cell Membrane Expansion by Acting on Syntaxin 3. Nature, 440, 813-817.
https://doi.org/10.1038/nature04598
[34] Calderon, F. and Kim, H.Y. (2007) Role of RXR in Neurite Outgrowth Induced by Docosahexaenoic Acid. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 77, 227-232.
[35] Perez, S.E., Berg, B.M., Moore, K.A., et al. (2010) DHA Diet Reduces AD Pathology in Young APPswe/PS1 Delta E9 Transgenic Mice: Possible Gender Effects. Journal of Neuroscience Research, 88, 1026-1040.
[36] Hooijmans, C.R., Van der Zee, C.E., Dederen, P.J., et al. (2009) DHA and Cholesterol Containing Diets Influence Alzheimer-Like Pathology, Cognition and Cerebral Vasculature in APPswe/PS1dE9 Mice. Neurobiology of Disease, 33, 482-498.
[37] Kim, H.Y. (2014) Neuroprotection by Docosahexaenoic Acid in Brain Injury. Military Medicine, 179, 106-111.
https://doi.org/10.7205/MILMED-D-14-00162
[38] Collaborators GBDEMRMH and Mokdad, A.H. (2017) The Burden of Mental Disorders in the Eastern Mediterranean Region, 1990-2015: Findings from the Global Burden of Disease 2015 Study. International Journal of Public Health, 1-13.
[39] Kratz, T. (2017) The Diagnosis and Treatment of Behavioral Disorders in Dementia. Deutsches Arzteblatt International, 114, 447-454.
[40] Chung, W.L., Chen, J.J. and Su, H.M. (2008) Fish Oil Supplementation of Control and (n-3) Fatty Acid-Deficient Male Rats Enhances Reference and Working Memory Performance and Increases Brain Regional Docosahexaenoic Acid Levels 1-3. The Journal of Nutrition, 138, 1165-1171.
[41] Yuki, D., Sugiura, Y., Zaima, N., et al. (2014) DHA-PC and PSD-95 Decrease after Loss of Synaptophysin and before Neuronal Loss in Patients with Alzheimer’s Disease. Scientific Reports, 4, 7130.
https://doi.org/10.1038/srep07130