成年期和青少年期使用抗精神病药对认知功能的不同影响
The Different Effects of Antipsychotic Drugs on Cognitive Function in Adulthood and Adolescence
DOI: 10.12677/AP.2018.810169, PDF,    科研立项经费支持
作者: 程 鹏, 高 军:西南大学心理学部,重庆
关键词: 抗精神病药认知功能成年期青少年期Antipsychotic Drugs Cognitive Function Adulthood Adolescence
摘要: 精神疾病患者的认知功能有一定程度的受损,而抗精神病药对认知功能又会产生消极或积极的影响。近几十年的药物研究很多都集中于成年期(人类和动物)用药对认知功能的影响,但对青少年期用药对认知功能影响的重视却不够,因此本文围绕成年期和青少年期使用抗精神病药对认知功能的影响展开论述。首先介绍了抗精神病药的种类及其应用,随后分别重点阐述了成年期和青少年期(包括人类被试及动物被试)使用抗精神病药对认知功能(注意功能、学习记忆功能和执行功能)的影响。最后分析两类人群使用药物对认知功能产生不同影响的原因,进一步指出未来的研究需要更加重视青少年期用药,以及脑内神经化学系统(如多巴胺系统和五羟色胺系统)之间的复杂相互作用。
Abstract: Cognitive function of psychotic is impaired to a certain extent, and the use of antipsychotics has an impact on cognitive function. In recent decades, drug research has focused on the effects of adult (human and animal) medication, but less attention was paid to the effects of adolescent medication on cognitive function. Firstly, the types and application of antipsychotics are introduced, and then the effects of antipsychotics on cognitive functions (attention, learning and memory, and executive function) in adulthood and adolescence (including human subjects and animal subjects) are discussed. Then, we try to discuss the underlying mechanisms for the different effects of drug used on cognitive function in the two ages. Finally, we point out that future research needs to pay more attention to the antipsychotic using in adolescence, and the complicated neural chemical (such as dopamine system and serotonin system).
文章引用:程鹏, 高军 (2018). 成年期和青少年期使用抗精神病药对认知功能的不同影响. 心理学进展, 8(10), 1452-1465. https://doi.org/10.12677/AP.2018.810169

参考文献

[1] 李红, 王乃弋(2004). 论执行功能及其发展研究. 心理科学, 27(2), 426-430.
[2] 彭聃龄(2001). 普通心理学 (修订版). 北京: 北京师范大学出版社.
[3] 杨治良(2011). 漫谈人类记忆的研究. 心理科学, (1), 249-250.
[4] Addy, N., & Levin, E. D. (2002). Nicotine Interactions with Haloperidol, Clozapine and Risperidone and Working Memory Function in Rats. Neuropsychopharmacology, 27, 534-541.[CrossRef
[5] Aman, M. G., Hollway, J. A., Leone, S., Masty, J., Lindsay, R., Nash, P., & Arnold, L. E. (2009). Effects of Risperidone on Cognitive-Motor Performance and Motor Movements in Chronically Medicated Children. Research in Developmental Disabilities, 30, 386-396.[CrossRef] [PubMed]
[6] Anderson, I. M., Haddad, P. M., & Scott, J. (2012). Bipolar Disorder. BMJ, 345, e8508.[CrossRef] [PubMed]
[7] Atti, A. R., Ferrari Gozzi, B., Zuliani, G., Bernabei, V., Scudellari, P., Berardi, D., Menchetti, M. et al. (2014). A Systematic Review of Metabolic Side Effects Related to the Use of Antipsychotic Drugs in Dementia. International Psychogeriatrics, 26, 19-37.
[8] Barak, S., & Weiner, I. (2011). Putative Cognitive Enhancers in Preclinical Models Related to Schizophrenia: The Search for an Elusive Target. Pharmacology Biochemistry and Behavior, 99, 164-189.[CrossRef] [PubMed]
[9] Bardgett, M. E., Baum, K. T., O’Connell, S. M., Lee, N. M., & Hon, J. C. (2006). Effects of Risperidone on Locomotor Activity and Spatial Memory in Rats with Hippocampal Damage. Neuropharmacology, 51, 1156-1162.[CrossRef] [PubMed]
[10] Bloechliger, M., Ruegg, S., Jick, S. S., Meier, C. R., & Bodmer, M. (2015). Antipsychotic Drug Use and the Risk of Seizures: Follow-Up Study with a Nested Case-Control Analysis. CNS Drugs, 29, 591-603.[CrossRef] [PubMed]
[11] Bowie, C. R., McLaughlin, D., Carrion, R. E., Auther, A. M., & Cornblatt, B. A. (2012). Cognitive Changes Following Antidepressant or Antipsychotic Treatment in Adolescents at Clinical Risk for Psychosis. Schizophrenia Research, 137, 110-117.[CrossRef] [PubMed]
[12] Burda, K., Czubak, A., Kus, K., Nowakowska, E., Ratajczak, P., & Zin, J. (2011). Influence of Aripiprazole on the Antidepressant, Anxiolytic and Cognitive Functions of Rats. Pharmacological Reports, 63, 898-907.[CrossRef
[13] Burda-Malarz, K., Kus, K., Ratajczak, P., Czubak, A., Nowakowska, E., Jedrzejewski, L., & Sadowski, C. (2014). Evaluation of Antidepressant and Memory-Improving Efficacy of Aripiprazole and Fluoxetine in Alcohol-Preferring Rats. Acta Neuropsychiatrica, 26, 112-119.[CrossRef] [PubMed]
[14] Carli, M., Calcagno, E., Mainolfi, P., Mainini, E., & Invernizzi, R. W. (2011). Effects of Aripiprazole, Olanzapine, and Haloperidol in a Model of Cognitive Deficit of Schizophrenia in Rats: Relationship with Glutamate Release in the Medial Prefrontal Cortex. Psychopharmacology, 214, 639-652.[CrossRef] [PubMed]
[15] Castro, C. C., Dos Reis-Lunardelli, E. A., Schmidt, W. J., Coitinho, A. S., & Izquierdo, I. (2007). Clozapine and Olanzapine but Not Risperidone Impair the Pre-Frontal Striatal System in Relation to Egocentric Spatial Orientation in a Y-Maze. Current Neurovascular Research, 4, 235-239.[CrossRef] [PubMed]
[16] Chang, S. W., McGuire, J. F., Walkup, J. T., Woods, D. W., Scahill, L., Wilhelm, S. et al. (2018). Neurocognitive Correlates of Treatment Response in Children with Tourette’s Disorder. Psychiatry Research, 261, 464-472.[CrossRef] [PubMed]
[17] Choi, Y. K., Gardner, M. P., & Tarazi, F. I. (2009). Effects of Risperidone on Glutamate Receptor Subtypes in Developing Rat Brain. European Neuropsychopharmacology, 19, 77-84.[CrossRef] [PubMed]
[18] Correll, C. U., Rubio, J. M., & Kane, J. M. (2018). What Is the Risk-Benefit Ratio of Long-Term Antipsychotic Treatment in People with Schizophrenia? World Psychiatry, 17, 149-160.[CrossRef] [PubMed]
[19] Dahoun, T., Trossbach, S. V., Brandon, N. J., Korth, C., & Howes, O. D. (2017). The Impact of Disrupted-in-Schizophrenia 1 (DISC1) on the Dopaminergic System: A Systematic Review. Translational Psychiatry, 7, e1015.[CrossRef] [PubMed]
[20] Demirkaya, S. K., Aksu, H., & Ozgur, B. G. (2017). A Retrospective Study of Long Acting Risperidone Use to Support Treatment Adherence in Youth with Conduct Disorder. Clinical Psychopharmacology and Neuroscience, 15, 328-336.[CrossRef] [PubMed]
[21] Deziel, R. A., Ryan, C. L., & Tasker, R. A. (2015). Ischemic Lesions Localized to the Medial Prefrontal Cortex Produce Selective Deficits in Measures of Executive Function in Rats. Behavioural Brain Research, 293, 54-61.[CrossRef] [PubMed]
[22] Dumontheil, I. (2014). Development of Abstract Thinking during Childhood and Adolescence: The Role of Rostrolateral Prefrontal Cortex. Developmental Cognitive Neuroscience, 10, 57-76.[CrossRef] [PubMed]
[23] Egerton, A., Ahmad, R., Hirani, E., & Grasby, P. M. (2008). Modulation of Striatal Dopamine Release by 5-HT2A and 5-HT2C Receptor Antagonists: [11C]Raclopride PET Studies in the Rat. Psychopharmacology (Berl), 200, 487-496.[CrossRef] [PubMed]
[24] Elsworth, J. D., Groman, S. M., Jentsch, J. D., Valles, R., Shahid, M., Wong, E. et al. (2012). Asenapine Effects on Cognitive and Monoamine Dysfunction Elicited by Subchronic Phencyclidine Administration. Neuropharmacology, 62, 1442-1452.[CrossRef] [PubMed]
[25] Fatouros-Bergman, H., Cervenka, S., Flyckt, L., Edman, G., & Farde, L. (2014). Meta-Analysis of Cognitive Performance in Drug-Naive Patients with Schizophrenia. Schizophrenia Research, 158, 156-162.[CrossRef] [PubMed]
[26] Forray, C., & Buller, R. (2017). Challenges and Opportunities for the Development of New Antipsychotic Drugs. Biochemical Pharmacology, 143, 10-24.[CrossRef] [PubMed]
[27] Goldberg, T. E., Goldman, R. S., Burdick, K. E., Malhotra, A. K., Lencz, T., Patel, R. C. et al. (2007). Cognitive Improvement after Treatment with Second-Generation Antipsychotic Medications in First-Episode Schizophrenia: Is It a Practice Effect? Archives of General Psychiatry, 64, 1115-1122.
[28] Guo, X., Zhai, J., Wei, Q., Twamley, E. W., Jin, H., Fang, M. et al. (2011). Neurocognitive Effects of First- and Second-Generation Antipsychotic Drugs in Early-Stage Schizophrenia: A Naturalistic 12-Month Follow-Up Study. Neuroscience Letters, 503, 141-146.[CrossRef] [PubMed]
[29] Hartz, I., Skurtveit, S., Steffenak, A. K., Karlstad, O., & Handal, M. (2016). Psychotropic Drug Use among 0 - 17 Year Olds during 2004-2014: A Nationwide Prescription Database Study. BMC Psychiatry, 16, 12.[CrossRef] [PubMed]
[30] Holzer, B., Lopes, V., & Lehman, R. (2013). Combination Use of Atomoxetine Hydrochloride and Olanzapine in the Treatment of Attention-Deficit/Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder in Children and Adolescents 10 - 18 Years of Age. Journal of Child and Adolescent Psychopharmacology, 23, 415-418.[CrossRef] [PubMed]
[31] Hori, H., Yoshimura, R., Katsuki, A., Hayashi, K., Ikenouchi-Sugita, A., Umene-Nakano, W., & Nakamura, J. (2012). Several Prescription Patterns of Antipsychotic Drugs Influence Cognitive Functions in Japanese Chronic Schizophrenia Patients. International Journal of Psychiatry in Clinical Practice, 16, 138-142.[CrossRef] [PubMed]
[32] Hsu, C. W., Lee, S. Y., & Wang, L. J. (2017). Comparison of the Effectiveness of Brand-Name and Generic Antipsychotic Drugs for Treating Patients with Schizophrenia in Taiwan. Schizophrenia Research, 193, 107-113.
[33] Hsu, S. W., Chiang, P. H., Chang, Y. C., Lin, J. D., Tung, H. J., & Chen, C. Y. (2014). Trends in the Use of Psychotropic Drugs in People with Intellectual Disability in Taiwan: A Nationwide Outpatient Service Study, 1997-2007. Research in Developmental Disabilities, 35, 364-372.[CrossRef] [PubMed]
[34] Husa, A. P., Moilanen, J., Murray, G. K., Marttila, R., Haapea, M., Rannikko, I. et al. (2017). Lifetime Antipsychotic Medication and Cognitive Performance in Schizophrenia at Age 43 Years in a General Population Birth Cohort. Psychiatry Research, 247, 130-138.[CrossRef] [PubMed]
[35] Hutchings, E. J., Waller, J. L., & Terry Jr., A. V. (2013). Differential Long-Term Effects of Haloperidol and Risperidone on the Acquisition and Performance of Tasks of Spatial Working and Short-Term Memory and Sustained Attention in Rats. Journal of Pharmacology and Experimental Therapeutics, 347, 547-556.[CrossRef] [PubMed]
[36] Keedy, S. K., Reilly, J. L., Bishop, J. R., Weiden, P. J., & Sweeney, J. A. (2015). Impact of Antipsychotic Treatment on Attention and Motor Learning Systems in First-Episode Schizophrenia. Schizophrenia Bulletin, 41, 355-365.[CrossRef] [PubMed]
[37] Keefe, R. S., Bilder, R. M., Davis, S. M., Harvey, P. D., Palmer, B. W., Gold, J. M. et al. (2007). Neurocognitive Effects of Antipsychotic Medications in Patients with Chronic Schizophrenia in the CATIE Trial. Archives of General Psychiatry, 64, 633-647.
[38] Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006). Nicotinic Effects on Cognitive Function: Behavioral Characterization, Pharmacological Specification, and Anatomic Localization. Psychopharmacology (Berl), 184, 523-539.[CrossRef] [PubMed]
[39] Loy, J. H., Merry, S. N., Hetrick, S. E., & Stasiak, K. (2017). Atypical Antipsychotics for Disruptive Behaviour Disorders in Children and Youths. Cochrane Database of Systematic Reviews, 8, CD008559.[CrossRef
[40] Maeda, K., Lerdrup, L., Sugino, H., Akazawa, H., Amada, N., McQuade, R. D. et al. (2014). Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of A Novel Serotonin-Dopamine Activity Modulator. Journal of Pharmacology and Experimental Therapeutics, 350, 605-614.[CrossRef] [PubMed]
[41] Maher, A. R., & Theodore, G. (2012). Summary of the Comparative Effectiveness Review on Off-Label Use of Atypical Antipsychotics. Journal of Managed Care Pharmacy, 18, S1-S20.[CrossRef
[42] Maia, T. V., & Frank, M. J. (2017). An Integrative Perspective on the Role of Dopamine in Schizophrenia. Biological Psychiatry, 81, 52-66.[CrossRef] [PubMed]
[43] Marston, H. M., Young, J. W., Martin, F. D., Serpa, K. A., Moore, C. L., Wong, E. H. et al. (2009). Asenapine Effects in Animal Models of Psychosis and Cognitive Function. Psychopharmacology (Berl), 206, 699-714.[CrossRef] [PubMed]
[44] Martinez, V., & Sarter, M. (2008). Detection of the Moderately Beneficial Cognitive Effects of Low-Dose Treatment with Haloperidol or Clozapine in an Animal Model of the Attentional Impairments of Schizophrenia. Neuropsychopharmacology, 33, 2635-2647.[CrossRef] [PubMed]
[45] McLean, S. L., Neill, J. C., Idris, N. F., Marston, H. M., Wong, E. H., & Shahid, M. (2010). Effects of Asenapine, Olanzapine, and Risperidone on Psychotomimetic-Induced Reversal-Learning Deficits in the Rat. Behavioural Brain Research, 214, 240-247.[CrossRef] [PubMed]
[46] Millier, A., Schmidt, U., Angermeyer, M. C., Chauhan, D., Murthy, V., Toumi, M., & Cadi-Soussi, N. (2014). Humanistic Burden in Schizophrenia: A Literature Review. Journal of Psychiatric Research, 54, 85-93.[CrossRef] [PubMed]
[47] Moe, A. A. K., Medely, G. A., Reeks, T., Burne, T. H. J., & Eyles, D. W. (2017). Short- and Long-Term Effects of Risperidone on Catalepsy Sensitisation and Acquisition of Conditioned Avoidance Response: Adolescent vs Adult Rats. Pharmacological Research, 121, 1-13.[CrossRef] [PubMed]
[48] Moe, R. O., Nordgreen, J., Janczak, A. M., Bakken, M., Spruijt, B. M., & Jensen, P. (2014). Anticipatory and Foraging Behaviors in Response to Palatable Food Reward in Chickens: Effects of Dopamine D2 Receptor Blockade and Domestication. Physiology & Behavior, 133, 170-177.[CrossRef] [PubMed]
[49] Moran-Gates, T., Grady, C., Shik Park, Y., Baldessarini, R. J., & Tarazi, F. I. (2007). Effects of Risperidone on Dopamine Receptor Subtypes in Developing rat Brain. European Neuropsychopharmacology, 17, 448-455.[CrossRef] [PubMed]
[50] Moritz, S., Andreou, C., Klingberg, S., Thoering, T., & Peters, M. J. (2013). Assessment of Subjective Cognitive and Emotional Effects of Antipsychotic Drugs. Effect by Defect? Neuropharmacology, 72, 179-186.[CrossRef] [PubMed]
[51] Mott, A. M., Nunes, E. J., Collins, L. E., Port, R. G., Sink, K. S., Hockemeyer, J. et al. (2009). The Adenosine A(2A) Antagonist MSX-3 Reverses the Effects of the Dopamine Antagonist Haloperidol on Effort-Related Decision Making in a T-Maze Cost/Benefit Procedure. Psychopharmacology (Berl), 204, 103-112.[CrossRef] [PubMed]
[52] Murai, T., Nakako, T., Ikejiri, M., Ishiyama, T., Taiji, M., & Ikeda, K. (2013). Effects of Lurasidone on Executive Function in Common Marmosets. Behavioural Brain Research, 246, 125-131.[CrossRef] [PubMed]
[53] Nikiforuk, A., & Popik, P. (2013). Amisulpride Promotes Cognitive Flexibility in Rats: The Role of 5-HT7 Receptors. Behavioural Brain Research, 248, 136-140.[CrossRef] [PubMed]
[54] Ning, H., Cao, D., Wang, H., Kang, B., Xie, S., & Meng, Y. (2017). Effects of Haloperidol, Olanzapine, Ziprasidone, and PHA-543613 on Spatial Learning and Memory in the Morris Water Maze Test in Naive and MK-801-Treated Mice. Brain and Behavior, 7, e00764.[CrossRef] [PubMed]
[55] Owen, M. J., Sawa, A., & Mortensen, P. B. (2016). Schizophrenia. The Lancet, 388, 86-97.[CrossRef
[56] Pandina, G. J., Zhu, Y., & Cornblatt, B. (2009). Cognitive Function with Long-Term Risperidone in Children and Adolescents with Disruptive Behavior Disorder. Journal of Child and Adolescent Psychopharmacology, 19, 749-756.[CrossRef] [PubMed]
[57] Pflibsen, L., Stang, K. A., Sconce, M. D., Wilson, V. B., Hood, R. L., Meshul, C. K., & Mitchell, S. H. (2015). Executive Function Deficits and Glutamatergic Protein Alterations in a Progressive 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson’s Disease. Journal of Neuroscience Research, 93, 1849-1864.[CrossRef] [PubMed]
[58] Pierre, J. M. (2005). Extrapyramidal Symptoms with Atypical Antipsychotics: Incidence, Prevention and Management. Drug Safety, 28, 191-208.[CrossRef] [PubMed]
[59] Ratajczak, P., Kus, K., Jarmuszkiewicz, Z., Wozniak, A., Cichocki, M., & Nowakowska, E. (2013). Influence of Aripiprazole and Olanzapine on Behavioral Dysfunctions of Adolescent Rats Exposed to Stress in Perinatal Period. Pharmacological Reports, 65, 30-43.[CrossRef
[60] Remberk, B., Namyslowska, I., & Rybakowski, F. (2012). Cognition and Communication Dysfunctions in Early-Onset Schizophrenia: Effect of Risperidone. Progress in Neu-ro-Psychopharmacology & Biological Psychiatry, 39, 348-354.[CrossRef] [PubMed]
[61] Russo, E., Citraro, R., Davoli, A., Gallelli, L., Di Paola, E. D., & De Sarro, G. (2013). Ameliorating Effects of Aripiprazole on Cognitive Functions and Depressive-Like Behavior in a Genetic Rat Model of Absence Epilepsy and Mild-Depression Comorbidity. Neuropharmacology, 64, 371-379.[CrossRef] [PubMed]
[62] Sacarny, A., Barnett, M. L., Le, J., Tetkoski, F., Yokum, D., & Agrawal, S. (2018). Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial. JAMA Psychiatry.
[63] Satoh, M., Obara, T., Nishigori, H., Ooba, N., Morikawa, Y., Ishikuro, M. et al. (2016). Prescription Trends in Children with Pervasive Developmental Disorders: A Claims Data-Based Study in Japan. World Journal of Pediatrics, 12, 443-449.[CrossRef] [PubMed]
[64] Scheggi, S., Pelliccia, T., Ferrari, A., De Montis, M. G., & Gambarana, C. (2015). Impramine, Fluoxetine and Clozapine Differently Affected Reactivity to Positive and Negative Stimuli in a Model of Motivational Anhedonia in Rats. Neuroscience, 291, 189-202.[CrossRef] [PubMed]
[65] Stip, E., Cherbal, A., Luck, D., Zhornitsky, S., Bentaleb, L. A., & Lungu, O. (2017). A Neuroimaging Study of Emotion-Cognition Interaction in Schizophrenia: The Effect of Ziprasidone Treatment. Psychopharmacology (Berl), 234, 1045-1058.[CrossRef] [PubMed]
[66] Strawn, J. R., Geracioti, L., Rajdev, N., Clemenza, K., & Levine, A. (2018). Pharmacotherapy for Generalized Anxiety Disorder in Adult and Pediatric Patients: An Evidence-Based Treatment Review. Expert Opinion on Pharmacotherapy, 19, 1057-1070.[CrossRef] [PubMed]
[67] Taylor, G. T., Smith, S. E., & Kirchhoff, B. A. (2013). Differential Effects of Antipsychotics on Lateral Bias and Social Attention in Female Rats. Psychopharmacology (Berl), 225, 453-460.[CrossRef] [PubMed]
[68] Tort, A. B., Souza, D. O., & Lara, D. R. (2006). Theoretical Insights into the Mechanism of Action of Atypical Antipsychotics. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30, 541-548.[CrossRef] [PubMed]
[69] Unschuld, P. G., Liu, X., Shanahan, M., Margolis, R. L., Bassett, S. S., Brandt, J. et al. (2013). Prefrontal Executive Function Associated Coupling Relates to Huntington’s Disease Stage. Cortex, 49, 2661-2673.[CrossRef] [PubMed]
[70] Vernon, A. C., Natesan, S., Modo, M., & Kapur, S. (2011). Effect of Chronic Antipsychotic Treatment on Brain Structure: A Serial Magnetic Resonance Imaging Study with ex Vivo and Postmortem Confirmation. Biological Psychiatry, 69, 936-944.[CrossRef] [PubMed]
[71] Vigen, C. L., Mack, W. J., Keefe, R. S., Sano, M., Sultzer, D. L., Stroup, T. S. et al. (2011). Cognitive Effects of Atypical Antipsychotic Medications in Patients with Alzheimer’s Disease: Outcomes from CATIE-AD. American Journal of Psychiatry, 168, 831-839.[CrossRef] [PubMed]
[72] Vita, A., De Peri, L., Deste, G., Barlati, S., & Sacchetti, E. (2015). The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-Analysis and Meta-Regression of Longitudinal Magnetic Resonance Imaging Studies. Biological Psychiatry, 78, 403-412.[CrossRef] [PubMed]
[73] Xu, S., Gullapalli, R. P., & Frost, D. O. (2015). Olanzapine Antipsychotic Treatment of Adolescent Rats Causes Long Term Changes in Glutamate and GABA Levels in the Nucleus Accumbens. Schizophrenia Research, 161, 452-457.[CrossRef] [PubMed]
[74] Xue, F., Chen, Y. C., Zhou, C. H., Wang, Y., Cai, M., Yan, W. J. et al. (2017). Risperidone Ameliorates Cognitive Deficits, Promotes Hippocampal Proliferation, and Enhances Notch Signaling in a Murine Model of Schizophrenia. Pharmacology Biochemistry and Behavior, 163, 101-109.[CrossRef] [PubMed]
[75] Yeh, C. B., Huang, Y. S., Tang, C. S., Wang, L. J., Chou, W. J., Chou, M. C., & Chen, C. K. (2014). Neurocognitive Effects of Aripiprazole in Adolescents and Young Adults with Schizophrenia. Nordic Journal of Psychiatry, 68, 219-224.[CrossRef] [PubMed]
[76] Zhang, C., Fang, Y., & Xu, L. (2014). Glutamate Receptor 1 Phosphorylation at Serine 845 Contributes to the Therapeutic Effect of Olanzapine on Schizophrenia-Like Cognitive Impairments. Schizophrenia Research, 159, 376-384.[CrossRef] [PubMed]