癫痫治疗仪控制方法研究综述
Review on the Control Methods of Epilepsy Therapeutic Apparatus
DOI: 10.12677/ACM.2019.92022, PDF,    科研立项经费支持
作者: 段博文, 孙海义：沈阳建筑大学理学院，辽宁 沈阳；李 宁：东北大学理学院，辽宁 沈阳
关键词: 癫痫治疗仪；控制方法；电刺激；迷走神经刺激；经颅磁刺激；Epilepsy Therapeutic Instrument； Control Method； Electrical Stimulation； Vagus Nerve Stimulation； Transcranial Magnetic Stimulation
摘要: 癫痫的治疗包括药物以及非药物治疗。由于癫痫的致病和治病机制到目前为止，尚未完全清楚，如果采取长期的药物治疗方式，一方面会造成一定程度的资源浪费，另一方面长期的药物治疗会存在一定抗药性和带来某些副作用。就目前而言，手术治疗和借助癫痫治疗仪治疗是非药物治疗的两种主要有效方法。但是，外科手术治疗会对人体造成非常大的伤害，所以不到迫不得已人们通常不会考虑手术治疗。借助癫痫治疗仪辅助治疗就成为了一部分患者的最佳选择之一，其主要治疗方法包括迷走神经刺激术、经颅磁刺激技术和电刺激。一部分癫痫患者选择这些新的治疗方法，并且这些新的治疗方法也可以用于治疗难治的癫痫，或是作为辅助治疗手段。最后对之前的相关研究结果进行了总结，并提出了一些今后的研究方向。
Abstract: The treatment of epilepsy includes drug therapy and non-drug therapy. Up to now, the pathogene-sis and treatment mechanism of epilepsy have not been fully understood. If the patient is on long-term medication, on the one hand, it will cause a certain degree of waste of resources; on the other hand, it will bring some drug resistance and side effects. At present, surgical treatment and treatment with epilepsy instrument are two main effective methods of non-drug treatment. How-ever, surgical treatment can cause so much harm that people don’t usually consider surgery unless they have to. Assisted treatment with epilepsy therapy instrument has become one of the best choices for some patients. The main treatment methods include vagus nerve stimulation, tran-scranial magnetic stimulation and electrical stimulation. Some epilepsy patients choose these new treatment methods, and these new treatment methods can also be used to treat refractory epilepsy, or as an adjuvant treatment. In the end, the previous research results are summarized, and some future research directions are proposed.
文章引用：段博文, 孙海义, 李宁. 癫痫治疗仪控制方法研究综述[J]. 临床医学进展, 2019, 9(2): 133-138. https://doi.org/10.12677/ACM.2019.92022

参考文献

[1] 王晓明, 陈俊杰, 周树舜. 癫痫的分子病理机理[J]. 中华医学遗传学杂志, 1996(13): 299-301.
[2] 周霖, 韦晓燕, 陈子怡, 等. 基于机器学习的癫痫脑电数据分析方法研究[J]. 医学信息学杂志, 2018, 39(2): 55-59.
[3] 丁美萍, Wang S, Chen C, 等. 精神社会因素与颞叶癫痫患者服用抗癫痫药物依从性之间的关系[J]. 癫痫杂志, 2018, 4(1): 84.
[4] Rui Qin, Shuai Cao, Tianjie Lyu, 等. CDYL功能缺失干扰神经元迁移增加小鼠癫痫易感性[J]. 科学新闻, 2018, 546(4): 131.
[5] Robert S, Fisher J, Helen Cross, 等. 2016年国际抗癫痫联盟癫痫发作分类的更新及介绍[J]. 癫痫杂志, 2017(1): 66-75.
[6] Bialer, M. and White, H.S. (2010) Key Factors in the Discovery and Development of New Antiepileptic Drugs. Nature Reviews Drug Discovery, 9, 68-82.
[7] Jobst, B. (2010) Brain Stimulation for Surgical Epilepsy. Epilepsy Research, 89, 154-161. [Google Scholar] [CrossRef] [PubMed]
[8] Berg, A.T. (2011) Epilepsy: Efficacy of Epilepsy Surgery: What Are the Questions Today? Nature Reviews Neurology, 7, 311-312. [Google Scholar] [CrossRef] [PubMed]
[9] 尚伟, 迟兆富. 癫痫持续状态的临床研究新进展[J]. 国际神经病学神经外科学杂志, 2001, 28(6):431-433.
[10] 王瑶. 探讨神经内科癫痫病患者的临床治疗效果研究[J]. 中国医药指南, 2018(3): 148-149.
[11] 张玉凤, 张利华, 李亚军, 等. 精准医学在癫痫中的应用[J]. 脑与神经疾病杂志, 2018(1): 61-64.
[12] 龙学平, 杨帆. 针刺治疗癫痫研究概况[J]. 中医药临床杂志, 2018(3): 387-389.
[13] Ben-Menachem, E., Revesz, D., Simon, B.J., et al. (2015) Surgically Implanted and Non-Invasive Vagus Nerve Stimulation: A Review of Efficacy, Safety and Tolerability. European Journal of Neurology, 22, 1260-1268.
[14] Houseton, T.X. (2002) Physician’s Manual for the VNS Therapy Pulse Model 102 Generator. Cyberonics Inc., Houston, 9-15.
[15] 关晨霞, 郭钢花, 李哲. 不同频率低频重复经颅磁刺激对有癫痫发作史的颅脑损伤患者认知功能的影响[J]. 华物理医学与康复杂志, 2016, 38(5): 349-352.
[16] 杨林萍. 经颅磁刺激脑性瘫痪中枢运动重构的机制研究[J]. 中国临床康复, 2003(7): 1938-1939.
[17] Epstein, C.M. (1998) Transcranial Mag-netic Stimulation: Language Function. Journal of Clinical Neurophysiology, 15, 325-332.
[18] 丁平, 梁树立. 复杂脑网络分析方法及其在癫痫诊疗中的应用[J]. 感染、炎症、修复, 2016, 17(3): 186-188.
[19] 贾兴, 孙海义. 复杂网络同步控制方法研究综述[J]. 动力系统与控制, 2018, 7(4): 318-327.
[20] Bernhardt, B.C., Bonilha, L. and Gross, D.W. (2015) Network Analysis for a Network Disorder: The Emerging Role of Graph Theory in the Study of Epilepsy. Epilepsy & Behavior, 50, 162-170. [Google Scholar] [CrossRef] [PubMed]
[21] 王江, 伊国胜, 边洪瑞, 韩春晓. 深度脑刺激的精确闭环去同步控制[J]. 天津大学学报(自然科学与工程技术版), 2013, 46(11): 969-976.
[22] 于海涛, 王江, 车艳秋, 邓斌, 魏熙乐. 非线性时滞反馈实现离散神经元网络的去同步化[J]. 动力学与控制学报, 2010, 18(4): 375-379.
[23] Li, N., Sun, H.Y. and Zhang, Q.L. (2017) The Controller Design of the eEpilepsy Therapy Apparatus. Mathematical Problems in Engineering, 1-8.
[24] Sun, H.Y., Li, N. and Chen, Z.T. (2017) Impulsive Synchronization Control of Coupled Neural Networks and Its Application on the Epilepsy Therapy. ICIC Express Letters, Part B: Applications, 8, 615-622.
[25] Alwan, M.S., Liu, X. and Liu, X. (2018) Deal with the Problem of Designing a Robust Reliable Decen-tralized Control for Impulsive Large-Scale Systems. Robust Reliable Control for Impulsive Scaled Systems, 7, 145-163.
[26] Wang, D., Huang, L., Tang, L., et al. (2018) Generalized Pinning Synchronization of Delayed Co-hen-Grossberg Neural Networks with Discontinuous Activations. Neural Networks, 104, 80-92. [Google Scholar] [CrossRef] [PubMed]
[27] Xie, W.B., Lim, C.C., Zhang, J. and Huang, L. (2017) New Approaches to Observer Design and Stability Analysis for T-S Fuzzy System with Multiplicative Noise. Journal of the Franklin Institute, 354, 887-901. [Google Scholar] [CrossRef] 

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