颅内生殖细胞肿瘤研究进展
Study Progress of Intracranial Germ Cell Tumors
DOI: 10.12677/ACM.2020.103043, PDF,  被引量   
作者: 高晓红, 白茫茫：延安大学附属医院神经外科，陕西 延安；王亚明：首都医科大学宣武医院神经外科，北京
关键词: 颅内生殖细胞肿瘤；诊断；治疗；MiRNA；Intracranial Germ Cell Tumors； Diagnosis； Therapy； MiRNA
摘要: 颅内生殖细胞肿瘤是一种好发于儿童及青少年的罕见肿瘤，常位于颅内松果体区、蝶鞍区和基底节区。组织类型通常分为生殖细胞瘤和非生殖细胞性生殖细胞肿瘤。临床表现与病变位置和大小相关。诊断分为临床诊断和活检病理诊断。治疗主要是放化疗和手术结合。新型肿瘤标志物MiroRNA (MiRNA)将来可能用于颅内生殖细胞肿瘤的诊断与治疗后评估。组织病理及分子病理的明确可为颅内生殖细胞肿瘤的分型及患者靶向治疗提供依据。本文对颅内生殖细胞瘤的发展现况及诊疗进展作一综述。
Abstract: Intracranial germ cell tumors (IGCTs) are uncommon tumours occurring in children and young adults with a tendency to appear in pineal, suprasellar and basal ganglia region. They are usually segregated into germinomas and nongerminomatous tumours (NGGCTs). The main clinical mani-festations of the tumors depend on their size and location. The diagnosis has been divided into clinical diagnosis and surgical biopsy pathology diagnosis. The tumor therapy regimen is mostly chemoradiotherapy and surgery. New tumor markers microRNA (MiRNA) may be potentially val-uable biomarkers in the diagnosis and evaluation of treatment of intracranial germ cell tumors in the future. Histopathology and molecular analyses are attempting to further specify the different IGCTs subtypes and are helping to direct the development of distinct therapeutic targets to improve treatment and prognosis. Here is to make a review of the current status and management in intracranial germ cell tumors
文章引用：高晓红, 王亚明, 白茫茫. 颅内生殖细胞肿瘤研究进展[J]. 临床医学进展, 2020, 10(3): 270-278. https://doi.org/10.12677/ACM.2020.103043

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