从中医角度探讨干细胞巢内的干细胞组成及其基本功能——干细胞巢及其群落就是经络系统的腧穴
Composition and Basic Functions of Stem Cells in Stem Cell Niches under the Lens of Traditional Chinese Medicine—Stem Cell Niches and Their Communities Are the Acupoints of the Meridian System
摘要: 经络是各种干细胞活动交流、协同进化的巨系统,主要表现为干细胞巢的出现以及不同种类干细胞巢的有序分布。在中医药物归经理论和君臣佐使理论的启发下,应用取类比象、隐喻认知的思维方法,作者认识到干细胞巢及其群落,不但是大多数种类成体干细胞赖以长期生存、更新分化的主要场所,而且是决定大中小血管和神经等细胞组织为什么各自具有特定解剖结构功能形态的基本单位,神经和大中小血管等都可以细分为一个个相对独立的“细胞组织单元”,其主要构成细胞的新陈代谢及其结构功能是由特定的干细胞巢统辖决定的。反过来说,通过解剖观察大中小血管和神经等中存在的主要构成细胞,就能得知相应干细胞巢中的干细胞组成及其基本功能。作者以此为突破口,重新认识理解中医理论中真气(为全能细胞Embryonic Stem Cell,ES胚胎干细胞)和元气(为Embryonic germ cell,EG胚胎干细胞,划分为七种)在经络内的功能行为,进一步阐释了经络的形成与进化规律,初步探讨了循经感传现象的机理和传统针灸理论。希望本文能够引起国内外干细胞研究者、经络研究者等的关注和研究兴趣,共同促进中西医理论逐渐融合为统一的科学理论。
Abstract: The meridian system of traditional Chinese medicine (TCM) is a giant system for various stem cell activities, communications and co-evolutions, mainly manifesting as the appearance and orderly distribution of different stem cell niches. Inspired by the TCM theories of “Meridian Attribution” and “Monarch, Minister, Assistant and envoy”, with the help of analogy by classification (a traditional pattern of thinking in TCM) and metaphorical cognition, the author recognizes that stem cell niches and their communities are not only the main place where a majority of adult stem cells survive, renew and differentiate, but also the basic unit that determines why large, medium and small blood vessels and nerves each have a specific anatomical structure and functional form. Nerves and large, medium and small blood vessels can be subdivided into "cell tissue units" that are relatively independent, and their metabolism, structure and function are governed by specific stem cell niches. Conversely, we can acquire information on the composition and basic functions of stem cells by dissecting and observing the main cells composing large, medium and small blood vessels and nerves. Therefore, it can be taken as a breakthrough to re-understand and understand the function and behavior of Genuine qi (known as embryonic stem cells) and Original qi (known as embryonic germ cells that can be divided into seven types) in the TCM meridian system, further explaining the formation and evolution of the meridians, and initially discussing the mechanism of the Propagated Sensation along the Channels and the traditional acupuncture theory. This review is attempted to arouse the attention and interest of researchers engaged in stem cells and meridians, thereby promoting the gradual coverage of Chinese and Western medical theories into a unified scientific theory.
文章引用:张建新. 从中医角度探讨干细胞巢内的干细胞组成及其基本功能——干细胞巢及其群落就是经络系统的腧穴[J]. 汉斯预印本, 2021, 6(1): 1-13. https://doi.org/10.12677/HANSPrePrints.2021.61004

参考文献

[1] 李鑫,邵瑞,王彧.中药调节神经干细胞增殖分化的研究进展[J].中国实验方剂学杂志,2019,25(09):221-227.DOI: 10.13422/j.cnki.syfjx.20190809
[2] 陈碧玮.经络研究何时走出困境——“七五”攻关以来的学术回顾[J].医学与哲学,2019,40(20):71-74. doi:10.12014/j.issn.1002-0772.2019.20.17
[3] 张明娟, 张建新. 不同种类干细胞巢的有序分布构成中医经络系统[J]. 中医学, 2021, 10(1): 67-79. https://doi.org/10.12677/TCM.2021.101008
[4] 郝宇卉,刘志贞,刘丹,冯玉娟,解 军.小鼠腹白线组织中Sca-1~+成体干细胞的分布[J]. 中国组织工程研究, 2019,23(17):2672-2677.http://www.cjter.com/CN/10.3969/j.issn.2095-4344.1721
[5] 张建新.干细胞巢的主要细胞成分及其组合模型[J].临床医学进展,2018,8(8):694-701. https://doi.org/10.12677/acm.2018.88117
[6] 张建新.胚胎干细胞的分化和多能干细胞巢模型——动物经络系统中胚胎干细胞的分化[J].中医学,2019,8(2):98-105.https://doi.org/10.12677/TCM.2019.82019
[7] 尹光丽,李建勇,缪扣荣.造血干细胞移植植入失败的研究进展[J].南京医科大学学报,2020,(1):141-146.DOI: 10.7655/NYDXBNS20200129
[8] Weston J . Migration and differentiation of neural crest cells.[J]. Advances in Morphogenesis, 1970, 8(4):41-114. https://doi.org/10.1016/B978-0-12-028608-9.50006-5
[9] 张建新.从进化论角度探讨干细胞分化及其干细胞巢分布规律[J]. 中国组织工程研究,2016,20(50):7571-7578. http://www.cjter.com/CN/10.3969/j.issn.2095-4344.2016.50.018
[10] 贺娟.《黄帝内经》本体论自然观——真气论[J]. 北京中医药大学学报, 2019, 42(3): 181-184. https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2019.03.001
[11] 石翎笙,贺娟. 《黄帝内经》“真气”本根论思想形成脉络探析[J]. 北京中医药大学学报, 2020, 43(4): 269-274. https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2020.04.001
[12] 李智慧, 王小平. 中医原气探析[J]. 北京中医药大学学报, 2019, 42(9): 709-712. https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2019.09.001
[13] 石翎笙, 贺娟. 《黄帝内经》元气思想溯源与辨疑[J]. 北京中医药大学学报, 2020, 43(7): 544-547. https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2020.07.003
[14] Fang B , Shi M , Liao L , et al. Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31-/CD34- Progenitors.[J]. J Hematother Stem Cell Res, 2003, 12(6):603-613. DOI: 10.1089/15258160360732632
[15] 赵春华,赵洋洋,韩钦,刘星霞,王世华.从亚全能干细胞角度解读远古医学[J]. 医学争鸣, 2013,4(2):1-5. DOI: CNKI:SUN:DSJY.0.2013-02-006
[16] 李红梅, 吴芬芳, 徐安龙. 基于“元精-元气论”阐释填精养脏法与干细胞移植修复组织损伤的理论同一性[J]. 北京中医药大学学报, 2019, 42(7): 536-540.https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2019.07.002
[17] 王传池, 胡镜清, 江丽杰, 许伟明.中医学与现代医学整体论的差别[J].中医杂志,2017,05:361-365.DOI: 10.13288/j.11-2166/r.2017.05.001
[18] 姜姗,赵京生. “阿是”本义与“阿是穴”由来[J]. 中国针灸, 2016,02:197-199. DOI: 10.13288/j.11-2166/r.2020.23.005
[19] 于友华,王永炎.论方剂“整体综合调节”的作用方式[J]. 中国中药杂志, 2003, 28(4) :289. DOI: 10.3321/j.issn:1001-5302.2003.04.001
[20] 马思思,贾春华,郭瑨. 基于“一个方剂是一个邦国”的方剂君臣佐使隐喻分析[J]. 北京中医药大学学报, 2019, 42(2): 93-98.https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2019.02.001
[21] 贾春华. 中医学“是什么”与“为什么”理论的探讨[J]. 北京中医药大学学报, 2020, 43(9): 709-713. https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2020.09.001
[22] 高黎, 贾春华, 吴彤. 基于词频分析法的中医营气卫气之论述[J]. 环球中医药, 2019, v.12(01):41-44. doi:10.3969/j.issn.1674-1749.2019.01.009
[23] 林宗龙, 李青. 神经干细胞巢成分及调节机制的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2019, 9(6):369-374. DOI: 10.3877/cma.j.issn.2095-1221.2019.06.009
[24] Huang, Y., Xu, Z., Xiong, S. et al. Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion. Nat Neurosci 21, 530–540 (2018).https://doi.org/10.1038/s41593-018-0090-8
[25] 党圆圆, 张洪钿, 徐如祥. 小胶质细胞在中枢神经系统创伤后的双重作用及调控机制[J]. 中华神经创伤外科电子杂志,2016, 2(5): 305-312. DOI: 10.3877/cma.j.issn.2095-9141.2016.05.011
[26] 王泽宁,侯博儒,姜呈,任海军.小胶质细胞对神经干细胞调控机制的研究进展[J].中华细胞与干细胞杂志(电子版),2020,10(3):172-176. DOI:10.3877/cma.j.issn.2095-1221.2020.03.006
[27] Zhang Y , Gao S , Xia J , et al. Hematopoietic Hierarchy – An Updated Roadmap[J]. Trends in Cell Biology, 2018, 28(12):976-986. https://doi.org/10.1016/j.tcb.2018.06.001
[28] 张森, 董芳, 刘子闲, 依马秀夫. 造血干细胞的谱系分化——巨核细胞来源[J]. 中国实验血液学杂志, 2020,28(3):1044-1048. DOI: 10.19746/j.cnki.issn1009-2137.2020.03.054
[29] Li, D., Xue, W., Li, M. et al. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature 564, 119–124 (2018). https://doi.org/10.1038/s41586-018-0709-7
[30] 朱晓梅,敖平.干细胞处于所有癌症的中心吗?[J].科学通报,2018,63(12):1076-1081. DOI:10.1360/N972018-00156
[31] 骆黎静,张宇迪,卢丹,魏薇,沈铿,曾建芳. 肿瘤干细胞学说的应用前景与争议[J]. 中国临床医生杂志, 2018, 46(11):18-22. doi:10.3969/j.issn.2095-8552.2018.11.006
[32] 柳瑞军.肿瘤转移——肿瘤干细胞的归巢行为[J].上海交通大学学报(医学版),2008,28(2):209-211. doi:10.3969/j.issn.1674-8115.2008.02.027
[33] Liu, M., Kuo, F., Capistrano, K.J. et al. TGF-βsuppresses type 2 immunity to cancer. Nature 587, 115-120 (2020). https://doi.org/10.1038/s41586-020-2836-1
[34] 田胜男,王 博,李 琦,黄元华,马燕琳. 诱导多能干细胞的安全性及应用研究进展[J]. 中国组织工程研究, 2017, 21(5): 815-820. http://www.cjter.com/CN/10.3969/j.issn.2095-4344.2017.05.026
[35] 蔡晨依, 孟飞龙, 饶琳, 刘云玥, 赵小立. 诱导多能干细胞技术及其在疾病研究中的应用[J]. 遗传, 2020, 42(11): 1042-1061. http://www.chinagene.cn/CN/10.16288/j.yczz.20-235
[36] 林驰, 郑美凤,黄涛,罗菊芬.“循经感传”的源流考证[J].中华中医药杂志,2017,32(12):5435-5438. DOI: CNKI:SUN:BXYY.0.2017-12-053
[37] 卓廉士.对“循经感传实验”的反思[J].中国针灸,2011,31(11):1045-1048. DOI: CNKI:SUN:ZGZE.0.2011-11-028
[38] 姜姗,张大庆.针灸的概念·理论·文献——近30年研究成果述略[J].中医杂志,2020,23:2044-2049. DOI:10.13288/j.11-2166/r.2020.23.005
[39] 张建斌,赵京生.张介宾对针灸理论的研究和阐释[J].中国针灸,2011,31(2):173-175. DOI: 10.13703/j.0255-2930.2011.02.027
[40] 梁兴森, 郑小飞, 王华军. 从干细胞方向研究针灸作用机制的研究进展[J]. 中华针灸电子杂志, 2020, 9(1):17-22. DOI: 10.3877/cma.j.issn.2095-3240.2020.01.008
[41] 姜姗, 赵京生. 曲意之气:针刺究竟补泻了什么[J]. 北京中医药大学学报, 2017, 40(7): 613-620. https://xb.bucm.edu.cn/CN/10.3969/j.issn.1006-2157.2017.07.015.