抑郁症个体奖赏敏感性异常及情绪失调的生物标记物
Biomarkers of Anhedonia and Mood Disorders in Depressed Individuals
摘要: 抑郁症是一种常见的复发性心境障碍，是当今世界范围内最常见的精神疾病之一。快感缺乏与情绪失调均是抑郁症的核心特征，反馈相关负波和晚期正成分分别为其生物标记物，根据目前的研究，反馈相关负波异常和晚期正成分异常与抑郁症之间存在关联，可以作为抑郁发作及抑郁症状程度加重的预测因素，对于早期诊断也有着重要意义。对大量的研究进行梳理之后发现，目前还存在着抑郁被试的筛选标准存在差异、反馈相关负波的来源、功能以及取值标准尚未统一的问题，并且，抑郁症的异质性对反馈相关负波以及晚期正成分是否有影响目前尚没有相关研究得出结论，在未来的研究中值得进一步深入探讨。
Abstract: Depression is a common recurrent mood disorder and one of the most common mental diseases in the world today. Anhedonia and mood disorders are the core characteristics of depression. Feedback-related negative and late positive component are the biomarkers, respectively. According to the current study, feedback-related negative abnormality and late positive component abnormality are associated with depression, which can be used as a predictor of depressive episode and aggravation of depressive symptoms, and is of great significance for early diagnosis. After sorting out a large number of studies, it is found that there are still differences in the screening criteria of depression subjects, and the source, function and value criteria of feedback-related negative have not been unified. In addition, whether the heterogeneity of depression has an effect on the feedback-related negative and the late positive component has not been concluded by relevant studies at present, which is worthy of further discussion in future studies.
文章引用：张欣, 王恩国 (2021). 抑郁症个体奖赏敏感性异常及情绪失调的生物标记物. 心理学进展, 11(6), 1410-1417. https://doi.org/10.12677/AP.2021.116158

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