去乙酰化酶家族成员2的研究进展

Research Progress of Sirtuin2

摘要: SIRT2作为Sirtuins家族的一员，基因位于常染色体19q13.2上，与细胞质中的微管蛋白共定位，主要存在于胰腺、肝脏、肌肉、脑等代谢相关组织中；是经典的III型组蛋白去乙酰化酶。研究表明，SIRT2主要通过对靶基因的翻译后修饰调控代谢通路；调节多种细胞功能，如有丝分裂、细胞分化、应激反应、细胞存活、和稳态，因此在健康和疾病中发挥着重要作用。目前针对SIRT2在诸如二型糖尿病、神经系统疾病、心血管疾病、癌症等中的研究已有众多的报道，但其在多种疾病中都表现出了双重性作用，既有保护性的，亦有伤害性的，这为临床治疗提供靶点带来了相当大的难题。我们综述了近年来国内外的相关文献，拟对SIRT2相关的临床疾病及分子机制作进一步阐述，期望对未来相关临床提供参考。

Abstract: As a member of the Sirtuins family, SIRT2 gene is located on auto-chromosome 19q13.2, colocalized with tubulin in cytoplasm, and mainly exists in metabolism re-lated tissues such as pancreas, liver, muscle and brain. It’s a classic type III histone deacetylase. Studies have shown that SIRT2 regulates metabolic pathways mainly through posttranslational modification of target genes. Regulates a variety of cellular functions, such as mitosis, cell differen-tiation, stress response, cell survival, and homeostasis, and thus plays an important role in health and disease. At present, there have been numerous reports on SIRT2’s role in such diseases as type 2 diabetes, nervous system diseases, cardiovascular diseases, cancer, etc. However, SIRT2 has shown dual effects in a variety of diseases, including both protective and harmful effects, which brings considerable difficulties in providing targets for clinical treatment. We reviewed relevant literatures at home and abroad in recent years, and planned to further elaborate the clinical dis-eases and molecular mechanisms related to SIRT2, hoping to provide reference for future clinical studies.