补阳还五汤干预炎症反应抗动脉粥样硬化研究进展

Research Progress of Buyang Huanwu Decoction Intervening in Inflammatory Response and Anti-Atherosclerosis

摘要: 动脉粥样硬化(atherosclerosis, AS)是一种慢性炎症性疾病，是心脑血管疾病的主要原因之一，对人类健康构成严重威胁。AS的发病机制涉及脂质代谢紊乱、氧化应激和炎症之间的相互作用，炎症反应贯穿着AS的始终。目前用于治疗AS的抗炎药物临床研究有限。同时，中医认为气虚血瘀是AS的主要病机。补阳还五汤出自清朝医家王清任所著《医林改错》，是益气活血法的代表方，可以通过调节炎症信号通路、抑制炎症反应来发挥抗AS作用。补阳还五汤整方及其主要化学活性成分均可通过多途径、多靶点、多机制协同调节、共同干预AS的发生、发展，发挥抗AS作用。因此，该文将从补阳还五汤单味药有效成分及成方所涉及炎症反应相关机制对AS的防治进行综述，为推进动脉粥样硬化的实验研究及临床治疗提供科学依据。

Abstract: Atherosclerosis (AS) is a chronic inflammatory disease, which is one of the main causes of cardio-vascular and cerebrovascular diseases, and poses a serious threat to human health. The pathogene-sis of AS involves the interaction between lipid metabolism disorders, oxidative stress and inflam-mation, and the inflammatory response runs through AS. At present, there are limited clinical studies on anti-inflammatory drugs used to treat AS. At the same time, traditional Chinese medicine believes that qi deficiency and blood stasis are the main pathogenesis of AS. Buyang Huanwu Decoc-tion is from “Correcting Errors in Medicine” written by Wang Qingren, a physician in the Qing Dyn-asty. It is a representative prescription for nourishing qi and promoting blood circulation. It can exert anti-AS effects by regulating inflammatory signaling pathways and inhibiting inflammatory responses. The whole prescription of Buyang Huanwu Decoction and its main chemically active components can co-regulate and jointly intervene in the occurrence and development of AS through multiple channels, multiple targets and multiple mechanisms, and exert anti-AS effects. Therefore, this paper will review the prevention and treatment of AS from the active ingredients of Buyang Huanwu Decoction single medicine and the relevant mechanisms of inflammatory response in-volved in, to provide scientific basis for promoting experimental research and clinical treatment of atherosclerosis.