可注射型面部微整形填充材料的研究进展
Research Process in Injectable Facial Micropigmentation Filler Materials
DOI: 10.12677/aac.2024.142011, PDF,    科研立项经费支持
作者: 李 珍：上海理工大学材料与化学学院，上海
关键词: 微整形填充材料；面部年轻化；可注射；微球；Microplastic Filler Materials； Facial Rejuvenation； Injectable； Microspheres
摘要: 20世纪后半叶以来，面部年轻化已经成为一种新的时尚潮流。由于注射整形技术操作便利、微伤小、安全可靠、恢复期短、效果立竿见影等优势颇受大众青睐，其市场需求呈现爆炸式增长，成为大众首选整形方式之一。因此，寻找更安全、生物相容性好、抗感染能力强、稳定性高、更持久的理想可注射面部微整形填充材料成为生物材料领域研究和开发的热点之一。本文基于材料组成分类对当前可注射型面部微整形填充材料的研究进展进行综述，并展望注射微整形未来的发展方向。
Abstract: From the late 20th century on, facial rejuvenation has become a new fashion trend. Due to the advantages of convenient operation, minimally invasiveness, high safety, short recovery period, and quick effects, injection plastic surgery techniques are quite popular among the public, whose market demand has shown explosive growth. It has become one of the preferred plastic surgery methods. Therefore, the search for ideal injectable facial micropigmentation fillers that are much safer, biocompatible, resistant to infection, stable and longer lasting has become one of the hotspots in the field of biomaterials. This article reviews the research progresses of injectable facial micropigmentation filler materials in recent years based on the classification of material composition, and looks forward to the future development direction of injectable micropigmentation.
文章引用：李珍. 可注射型面部微整形填充材料的研究进展[J]. 分析化学进展, 2024, 14(2): 86-94. https://doi.org/10.12677/aac.2024.142011

参考文献

[1] Griffiths, D. and Mullock, A. (2017) Cosmetic Surgery: Regulatory Challenges in a Global Beauty Market. Health Care Analysis, 26, 220-234. [Google Scholar] [CrossRef] [PubMed]
[2] Li, M., Vierkötter, A., Schikowski, T., et al. (2015) Epidemiological Evidence That Indoor Air Pollution From Cooking with Solid Fuels Accelerates Skin Aging in Chinese Women. Journal of Dermatological Science, 79, 148-154. [Google Scholar] [CrossRef] [PubMed]
[3] Walker, M. (2022) Human Skin through the Ages. International Journal of Pharmaceutics, 622, Article ID: 121850. [Google Scholar] [CrossRef] [PubMed]
[4] Carruthers, J.D.A. and Carruthers, J.A. (2013) Treatment of Glabellar Frown Lines with C. Botulinum-A Exotoxin. The Journal of Dermatologic Surgery and Oncology, 18, 17-21. [Google Scholar] [CrossRef] [PubMed]
[5] Wang, L.L., Thomas, W.W. and Friedman, O. (2018) Granuloma Formation Secondary to Silicone Injection for Soft-Tissue Augmentation in Facial Cosmetics: Mechanisms and Literature Review. Ear, Nose & Throat Journal, 97, E46-E51. [Google Scholar] [CrossRef] [PubMed]
[6] Zappi, E., Barnett, J.G., Zappi, M., et al. (2007) The Long-Term Host Response to Liquid Silicone Injected during Soft Tissue Augmentation Procedures: A Microscopic Appraisal. Dermatologic Surgery, 33, S186-S192. [Google Scholar] [CrossRef] [PubMed]
[7] Lowe, N.J., Maxwell, C.A. and Patnaik, R. (2005) Adverse Reactions to Dermal Fillers. Dermatologic Surgery, 31, 1626-1633. [Google Scholar] [CrossRef] [PubMed]
[8] Hu, H.C., Fang, H.W. and Chiu, Y.H. (2017) Delayed-Onset Edematous Foreign Body Granulomas 40 Years after Augmentation Rhinoplasty by Silicone Implant Combined with Liquid Silicone Injection. Aesthetic Plastic Surgery, 41, 637-640. [Google Scholar] [CrossRef] [PubMed]
[9] Zou, H., Mo, R., Wang, S., et al. (2023) Analysis of Breast Follow-Up Results in Patients after Polyacrylamide Hydrogel (PAAG) or Silicone Prosthesis Removal. Journal of Plastic, Reconstructive & Aesthetic Surgery, 77, 219-227. [Google Scholar] [CrossRef] [PubMed]
[10] 康深松, 张正文, 翟宏峰, 等. 聚丙烯酰胺水凝胶面部注射术并发症分析[J]. 中华整形外科杂志, 2003, 19(5): 325-327.
[11] Ding, F. and Zhou, X. (2022) Additional Thoughts on Management of Complications Caused by Augmentation with Polyacrylamide Hydrogel with Two Different Strategies. Aesthetic Plastic Surgery, 47, 92-94. [Google Scholar] [CrossRef] [PubMed]
[12] Chau, A.L., Pugsley, C.D., Miyamoto, M.E., et al. (2023) PH-Dependent Friction of Polyacrylamide Hydrogels. Tribology Letters, 71, Article No. 108. [Google Scholar] [CrossRef] 
[13] Laurent, T.C., Laurent, U.B. and Fraser, J.R.E. (2017) The Structure and Function of Hyaluronan: An Overview. Immunology & Cell Biology, 74, a1-a7. [Google Scholar] [CrossRef] [PubMed]
[14] 石华堂, 张威, 于广兰, 等. 透明质酸的基础研究及整形美容外科临床应用进展[J]. 中国美容整形外科杂志, 2022, 33(4): 251-253.
[15] Bukhari, S.N.A., Roswandi, N.L., Waqas, M., et al. (2018) Hyaluronic Acid, a Promising Skin Rejuvenating Biomedicine: A Review of Recent Updates and Pre-Clinical and Clinical Investigations on Cosmetic and Nutricosmetic Effects. International Journal of Biological Macromolecules, 120, 1682-1695. [Google Scholar] [CrossRef] [PubMed]
[16] Gerup, B., Berg, P. and Kermark, C. (2005) Non-Animal Stabilized Hyaluronic Acid. BioDrugs, 19, 23-30. [Google Scholar] [CrossRef] [PubMed]
[17] Khosravani, N., Weber, L., Patel, R., et al. (2019) The 5-Step Filler Hand Rejuvenation: Filling with Hyaluronic Acid. Plastic and Reconstructive Surgery—Global Open, 7, e2073. [Google Scholar] [CrossRef] 
[18] Schuurmans, C.C.L., Mihajlovic, M., Hiemstra, C., et al. (2021) Hyaluronic Acid and Chondroitin Sulfate (Meth) Acrylate-Based Hydrogels for Tissue Engineering: Synthesis, Characteristics and Pre-Clinical Evaluation. Biomaterials, 268, Article ID: 120602. [Google Scholar] [CrossRef] [PubMed]
[19] Zheng, C., Fu, Q., Zhou, G.W., et al. (2022) Efficacy of Percutaneous Intraarterial Facial/Supratrochlear Arterial Hyaluronidase Injection for Treatment of Vascular Embolism Resulting from Hyaluronic Acid Filler Cosmetic Injection. Aesthetic Surgery Journal, 42, 649-655. [Google Scholar] [CrossRef] [PubMed]
[20] Sadeghi, P. and Meyers, A. (2021) Tissue Fillers for the Nasolabial Fold Area: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Aesthetic Plastic Surgery, 46, 25-26. [Google Scholar] [CrossRef] [PubMed]
[21] Nicolle, F.V. (1982) Use of Zyderm in the Aging Face. Aesthetic Plastic Surgery, 6, 193-195. [Google Scholar] [CrossRef] 
[22] Kim, J.H., Kwon, T.R., Hong, S.W., et al. (2019) Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler. Aesthetic Plastic Surgery, 43, 1095-1101. [Google Scholar] [CrossRef] [PubMed]
[23] Basyoni, R.R.H., Hassan, A.M., Mohammed, D.A., et al. (2022) Facial Rejuvenation by Microneedling with Irradiated Amniotic Collagen Matrix Compared to Platelet Rich Plasma. Dermatologic Therapy, 35, e15739. [Google Scholar] [CrossRef] [PubMed]
[24] Lotz, C., Schmid, F.F., Oechsle, E., et al. (2017) Cross-Linked Collagen Hydrogel Matrix Resisting Contraction to Facilitate Full-Thickness Skin Equivalents. ACS Applied Materials & Interfaces, 9, 20417-20425. [Google Scholar] [CrossRef] [PubMed]
[25] Jia, Y., Qiu, L., Zhang, H., Li, Z., et al. (2024) Efficacy and Safety of Type III Collagen Lyophilized Fibers Using Mid-To-Deep Dermal Facial Injections for the Correction of Dynamic Facial Wrinkles. Aesthetic Plastic Surgery. [Google Scholar] [CrossRef] [PubMed]
[26] Lemperle, G., Sadick, N.S., Knapp, T.R., et al. (2009) ArteFill® Permanent Injectable for Soft Tissue Augmentation: II. Indications and Applications. Aesthetic Plastic Surgery, 34, 273-286. [Google Scholar] [CrossRef] [PubMed]
[27] Wilson, Y. and Ellis, D. (2011) Permanent Soft Tissue Fillers. Facial Plastic Surgery, 27, 540-546. [Google Scholar] [CrossRef] [PubMed]
[28] Katz, B., Lehman, A., Misev, V., et al. (2021) A 12-Month Study to Evaluate Safety and Efficacy of Polymethylmethacrylate-Collagen Gel for Correction of Midface Volume Loss Using a Blunt Cannula as Measured by 3-D Imaging. Dermatologic Surgery, 47, 365-369. [Google Scholar] [CrossRef] 
[29] Nie, F., Xie, H., Wang, G., et al. (2019) Risk Comparison of Filler Embolism between Polymethyl Methacrylate (PMMA) and Hyaluronic Acid (HA). Aesthetic Plastic Surgery, 43, 853-860. [Google Scholar] [CrossRef] [PubMed]
[30] Solomon, P., Ng, C.L., Kerzner, J., et al. (2020) Facial Soft Tissue Augmentation with Bellafill: A Review of 4 Years of Clinical Experience in 212 Patients. Plastic Surgery, 29, 98-102. [Google Scholar] [CrossRef] [PubMed]
[31] 王赫, 王洪杰, 赵远航, 等. 生物质基聚乳酸材料改性研究进展[J]. 塑料工业, 2022, 50(4): 17-22.
[32] Han, W.Y., Kim, H.J., Kwon, R., et al. (2023) Safety and Efficacy of Poly-L-Lactic Acid Filler (Gana V vs. Sculptra) Injection for Correction of the Nasolabial Fold: A Double-Blind, Non-Inferiority, Randomized, Split-Face Controlled Trial. Aesthetic Plastic Surgery, 47, 1796-1805. [Google Scholar] [CrossRef] [PubMed]
[33] Chen, S.Y., Lin, J.Y. and Lin, C.Y. (2019) Compositions of Injectable Poly-D, L-Lactic Acid and Injectable Poly-L-Lactic Acid. Clinical and Experimental Dermatology, 45, 347-348. [Google Scholar] [CrossRef] [PubMed]
[34] Lin, M.J., Dubin, D.P., Goldberg, D.J., et al. (2019) Practices in the Usage and Reconstitution of Poly-L-Lactic Acid. Journal of Drugs in Dermatology, 18, 880-886.
[35] Oh, S., Lee, J.H., Kim, H.M., et al. (2023) Poly-L-Lactic Acid Fillers Improved Dermal Collagen Synthesis by Modulating M2 Macrophage Polarization in Aged Animal Skin. Cells, 12, Article 1320. [Google Scholar] [CrossRef] [PubMed]
[36] Graivier, M.H., Bass, L.S., Busso, M., et al. (2007) Calcium Hydroxylapatite (Radiesse) for Correction of the Mid-and Lower Face: Consensus Recommendations. Plastic and Reconstructive Surgery, 120, 55S-66S. [Google Scholar] [CrossRef] [PubMed]
[37] Nowag, B., Schäfer, D., Hengl, T., et al. (2023) Biostimulating Fillers and Induction of Inflammatory Pathways: A Preclinical Investigation of Macrophage Response to Calcium Hydroxylapatite and Poly-L Lactic Acid. Journal of Cosmetic Dermatology, 23, 99-106. [Google Scholar] [CrossRef] [PubMed]
[38] Marmur, E.S., Phelps, R. and Goldberg, D.J. (2009) Clinical, Histologic and Electron Microscopic Findings after Injection of a Calcium Hydroxylapatite Filler. Journal of Cosmetic and Laser Therapy, 6, 223-226. [Google Scholar] [CrossRef] [PubMed]
[39] Pavicic, T., Sattler, G., Fischer, T., et al. (2022) Calcium Hydroxyapatite Filler with Integral Lidocaine CaHA ( ) for Soft Tissue Augmentation: Results from an Open-Label Multicenter Clinical Study. Journal of Drugs in Dermatology, 21, 481-487. [Google Scholar] [CrossRef] 
[40] Massidda, E. (2023) Starting Point for Protocols on the Use of Hyperdiluted Calcium Hydroxylapatite (Radiesse®) for Optimizing Age-Related Biostimulation and Rejuvenation of Face, Neck, Décolletage and Hands: A Case Series Report. Clinical, Cosmetic and Investigational Dermatology, 16, 3427-3439. [Google Scholar] [CrossRef] 
[41] Angelo-Khattar, M. (2022) Objective Assessment of the Long-Term Volumizing Action of a Polycaprolactone-Based Filler. Clinical, Cosmetic and Investigational Dermatology, 15, 2895-2901. [Google Scholar] [CrossRef] 
[42] Kim, J.S. (2019) Changes in Dermal Thickness in Biopsy Study of Histologic Findings after a Single Injection of Polycaprolactone-Based Filler into the Dermis. Aesthetic Surgery Journal, 39, NP484-NP494. [Google Scholar] [CrossRef] [PubMed]
[43] Galadari, H., Van Abel, D., Al Nuami, K., et al. (2015) A Randomized, Prospective, Blinded, Split-Face, Single-Center Study Comparing Polycaprolactone to Hyaluronic Acid for Treatment of Nasolabial Folds. Journal of Cosmetic Dermatology, 14, 27-32. [Google Scholar] [CrossRef] [PubMed]
[44] Marefat, A., Dadkhahfar, S., Tahvildari, A., et al. (2022) The Efficacy of Polycaprolactone Filler Injection on Enlarged Facial Pores. Dermatologic Therapy, 35, e15600. [Google Scholar] [CrossRef] [PubMed]
[45] Sommerfeld, S.D., Cherry, C., Schwab, R.M., et al. (2019) Interleukin-36γ—Producing Macrophages Drive IL-17— Mediated Fibrosis. Science Immunology, 4, eaax4783. [Google Scholar] [CrossRef] [PubMed]

为你推荐