女性复发性尿路感染的非抗生素疗法

Nonantibiotic Therapy for Recurrent Urinary Tract Infection in Women

摘要: 复发性尿路感染是女性常见的泌尿系统疾病，反复发作不仅严重影响生活质量，还加剧抗生素药物的使用及耐药问题。近年来，多种非抗生素措施在复发性尿路感染的治疗中展现出潜力。包括局部激素治疗、免疫干预、生活方式调整、膳食补充剂等非抗生素疗法，其在复发性尿路感染中的临床效果突出，显著减少复发率、延缓复发时间、减少抗生素耐药性等，但目前尚不能完全取代传统治疗。未来还需要大样本、多中心的随机对照试验验证其疗效，并探索联合及个体化干预策略，为临床治疗复发性尿路感染提供诊疗新思路。

Abstract: Recurrent urinary tract infection (rUTI) is a common urological condition in women. Its frequent relapses not only impair quality of life but also lead to increased antibiotic use and the emergence of resistance. In recent years, various non-antibiotic strategies have shown promise in the management of rUTI. These include topical hormone therapy, immunomodulation, lifestyle modifications, and dietary supplements, which have demonstrated clinical benefits by reducing recurrence rates, prolonging recurrence intervals, and mitigating antibiotic resistance. However, such interventions cannot yet fully replace conventional antibiotic therapy. Future large-scale, multicenter randomized controlled trials are warranted to further validate their efficacy and safety, as well as to explore combined and individualized approaches, thereby providing new insights into the clinical management of rUTI.