黄葵胶囊治疗糖尿病肾病临床疗效文献分析

Literature Analysis on Clinical Efficacy of Huangkui Capsule in Treating Diabetic Nephropathy

摘要: 黄蜀葵花为锦葵科秋葵属植物黄蜀葵的干燥花冠，味甘、性凉，入心、肾、膀胱三经；功效利水通淋、清热解毒、活血通络。动物实验及临床验证表明该药具有抗炎、利尿、扩张血管、缓解血管痉挛、使已聚集的血小板解聚、缓解血液高凝状态、降低全血黏度等作用；其治疗糖尿病肾病的作用机制主要为抑制免疫反应、减轻炎症反应、改善肾纤维化、保护肾小管上皮细胞等；在临床上能有效降低蛋白尿，保护肾功能，改善肾脏病变进程。本文对近十年有关黄葵胶囊治疗糖尿病肾病疗效观察的文献进行汇总分析，为临床应用作一参考。

Abstract: Abelmoschus manihot is the dry corolla of mallow family okra, sweet and cool, entering the heart, kidney and bladder three channels. The efficacy of abelmoschus manihot is to induce diuresis, clear heat and detoxify, and promote blood circulation. Animal experiments and clinical verification show that the drug has the effects of anti-inflammatory, diuretic, vasodilation, vasospasm relief, aggregation of platelet depolymerization, blood hypercoagulability relief, blood viscosity reduction, etc.; the mechanism of its treatment of diabetic nephropathy is mainly to inhibit immune response, reduce inflammatory response, improve renal fibrosis, protect renal tubular epithelial cells, etc.; in clinical, it can effectively reduce proteinuria, protect renal function and improve renal pathological process. In this paper, the literature about the therapeutic effect of Huangkui Capsule on diabetic nephropathy in recent ten years was summarized and analyzed for reference in clinical application.