长链非编码RNA调控急性髓系白血病细胞糖代谢的研究进展
Research Progress of Long Non-Coding RNA Regulating Glucose Metabolism in Acute My-eloid Leukemia Cells
摘要: 急性髓系白血病(AML)是一种髓系造血干/祖细胞的克隆性恶性疾病，具有高度侵袭性和异质性。细胞内能量代谢途径改变是肿瘤的十大特征之一，其中葡萄糖代谢异常最为突出。肿瘤细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。长链非编码RNA (long noncoding RNA, lncRNA)是一类长度超过200 nt且不编码蛋白质的RNA分子，其可以在转录水平、转录后水平和表观遗传学等方面发挥重要的调控作用，影响细胞的增殖、分化、凋亡和耐药等生物学过程。越来越多研究发现，长链非编码RNA (lncRNA)在多种类型肿瘤中通过调节葡萄糖转运蛋白及关键酶表达及活性，或者调节代谢相关信号通路影响葡萄糖代谢。本文对lncRNA调控AML有氧糖酵解的有关机制进行综述，旨在为AML的生物标志及治疗靶点提供潜在依据。
Abstract: Acute myeloid leukemia (AML) is a clonal malignant disease of myeloid stem/progenitor cells, which is highly invasive and heterogeneous. The alteration of intracellular energy metabolism pathway is one of the ten characteristics of tumor, among which the abnormal glucose metabolism is the most prominent. Tumor cells show an increased dependence on glycolysis to meet their en-ergy needs, whether or not adequate oxygen is present. Long noncoding RNA (lncRNA) is a class of RNA molecules that are longer than 200 nt and do not encode proteins. LncRNA can play an im-portant regulatory role in transcriptional level, post-transcriptional level and epigenetics, affecting biological processes such as cell proliferation, differentiation, apoptosis and drug resistance. More and more studies have found that long non-coding RNA (lncRNA) affects glucose metabolism in var-ious types of tumors by regulating the expression and activity of glucose transporters and key en-zymes, or regulating signaling pathways related to metabolism. This article reviews the relevant mechanisms of lncRNA regulation of aerobic glycolysis in AML, aiming to provide potential basis for biomarkers and therapeutic targets of AML.
文章引用：王汉, 葛繁梅. 长链非编码RNA调控急性髓系白血病细胞糖代谢的研究进展[J]. 临床医学进展, 2022, 12(8): 7865-7870. https://doi.org/10.12677/ACM.2022.1281133

参考文献

[1] Döhner, H., Weisdorf, D.J. and Bloomfield, C.D. (2015) Acute Myeloid Leukemia. The New England Journal of Medi-cine, 373, 1136-1152. [Google Scholar] [CrossRef] 
[2] Short, N.J. and Ravandi, F. (2016) Acute Myeloid Leukemia: Past, Present, and Prospects for the Future. Clinical Lymphoma, Myeloma and Leukemia, 16, S25-S29. [Google Scholar] [CrossRef] [PubMed]
[3] Döhner, H., Estey, E.H., Amadori, S., et al. (2010) Di-agnosis and Management of Acute Myeloid Leukemia in Adults: Recommendations from an International Expert Panel, on Behalf of the European LeukemiaNet. Blood, 115, 453-474. [Google Scholar] [CrossRef] [PubMed]
[4] Warburg, O. (1956) On the Origin of Cancer Cells. Science, 123, 309-314. [Google Scholar] [CrossRef] [PubMed]
[5] Warburg, O. (1928) The Chemical Constitution of Respiration Ferment. Science, 68, 437-443. [Google Scholar] [CrossRef] [PubMed]
[6] Lunt, S.Y. and Vander Heiden, M.G. (2011) Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation. Annual Review of Cell and Developmental Biology, 27, 441-464. [Google Scholar] [CrossRef] [PubMed]
[7] Peppicelli, S., Bianchini, F. and Calorini, L. (2014) Extracellular Acidity, a “Reappreciated” Trait of Tumor Environment Driving Malignancy: Perspectives in Diagnosis and Therapy. Cancer and Metastasis Reviews, 33, 823-832. [Google Scholar] [CrossRef] [PubMed]
[8] Fan, C., Tang, Y., Wang, J., et al. (2017) Role of Long Non-Coding RNAs in Glucose Metabolism in Cancer. Molecular Cancer, 16, Article No. 130. [Google Scholar] [CrossRef] [PubMed]
[9] 杨一言, 高继萍, 续国强, 等. 非编码RNA调控口腔鳞状细胞癌葡萄糖代谢重编程的研究进展[J]. 中国比较医学杂志, 2022, 32(3): 91-97.
[10] Mathupala, S.P., Ko, Y.H. and Pedersen, P.L. (2006) Hexokinase II: Cancer’s Double-Edged Sword Acting as Both Facilitator and Gatekeeper of Ma-lignancy When Bound to Mitochondria. Oncogene, 25, 4777-4786. [Google Scholar] [CrossRef] [PubMed]
[11] Ju, H.Q., Zhan, G., Huang, A., et al. (2017) ITD Mutation in FLT3 Tyrosine Kinase Promotes Warburg Effect and Renders Therapeutic Sensitivity to Glycolytic Inhibition. Leukemia, 31, 2143-2150. [Google Scholar] [CrossRef] [PubMed]
[12] Ma, P., Xing, M., Han, L., et al. (2020) High PD-L1 Expression Drives Glycolysis via an Akt/mTOR/HIF-1α Axis in Acute Myeloid Leukemia. Oncology Reports, 43, 999-1009. [Google Scholar] [CrossRef] [PubMed]
[13] Sánchez-Martínez, C. and Aragón, J.J. (1997) Analysis of Phos-phofructokinase Subunits and Isozymes in Ascites Tumor Cells and Its Original Tissue, Murine Mammary Gland. FEBS Letters, 409, 86-90. [Google Scholar] [CrossRef] 
[14] Luo, X., Zheng, D., Zheng, R., et al. (2018) The Platelet Isoform of Phosphofructokinase in Acute Myeloid Leukemia: Clinical Relevance and Prognostic Implication. Blood, 132, 5251. [Google Scholar] [CrossRef] 
[15] Qing, Y., Dong, L., Gao, L., et al. (2021) R-2-Hydroxyglutarate Attenuates Aerobic Glycolysis in Leukemia by Targeting the FTO/m6A/PFKP/LDHB Axis. Mo-lecular Cell, 81, 922-939.e9. [Google Scholar] [CrossRef] [PubMed]
[16] Yang, G.J., Wu, J., Leung, C.H., et al. (2021) A Review on the Emerging Roles of Pyruvate Kinase m2 in Anti-Leukemia Therapy. International Journal of Biological Macromolecules, 193, 1499-1506. [Google Scholar] [CrossRef] [PubMed]
[17] Huang, Y., Chen, L.M., Xie, J.Y., et al. (2021) High Expres-sion of PKM2 Was Associated with the Poor Prognosis of Acute Leukemia. Cancer Management and Research, 13, 7851-7858. [Google Scholar] [CrossRef] 
[18] Wu, H., Zhao, H. and Chen, L. (2020) Deoxyshikonin Inhibits Viability and Glycolysis by Suppressing the Akt/mTOR Pathway in Acute Myeloid Leukemia Cells. Frontiers in Oncology, 10, Article No. 1253. [Google Scholar] [CrossRef] [PubMed]
[19] Augoff, K. and Grabowski, K. (2004) Przydatność oznaczania dehy-drogenazy mleczanowej w rozpoznawaniu chorób nowotworowych [Significance of Lactate Dehydrogenase Measure-ments in Diagnosis of Malignancies]. Polski Merkuriusz Lekarski, 17, 644-647.
[20] Kolev, Y., Uetake, H., Takagi, Y., et al. (2008) Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypox-ia-Inducible Factor (HIF-1alpha) Pathway, Angiogenic Factors Production and Poor Prognosis. Annals of Surgical On-cology, 15, 2336-2344. [Google Scholar] [CrossRef] [PubMed]
[21] Porporato, P.E., Dhup, S., Dadhich, R.K., et al. (2011) Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review. Frontiers in Phar-macology, 2, Article No. 49. [Google Scholar] [CrossRef] [PubMed]
[22] Qi, H.X., Cao, Q., Zhou, G.P., et al. (2019) MicroRNA 34b Inhibits Cell Proliferation in Pediatric Acute Myeloid Leukemia via Regulating LDHA. European Review for Medical and Pharmacological Sciences, 23, 5351-5359.
[23] 程薇, 杨丽萍, 周建奖, 等. 过表达CagA对胃癌细胞中GLUT1表达的影响[J]. 贵州医科大学学报, 2021, 46(4): 381-386. [Google Scholar] [CrossRef] 
[24] Pragallapati, S. and Manyam, R. (2019) Glucose Transporter 1 in Health and Disease. Journal of Oral and Maxillofacial Pathology, 23, 443-449. [Google Scholar] [CrossRef] 
[25] Adams, B.D., Parsons, C., Walker, L., Zhang, W.C. and Slack, F.J. (2017) Targeting Noncoding RNAs in Disease. Journal of Clinical Investigation, 127, 761-771. [Google Scholar] [CrossRef] 
[26] Wang, Y., Zou, Y., Zhang, Q., et al. (2022) LncRNA SBF2-AS1 Facilitates Nonsmall Cell Lung Cancer Progression by Targeting miR-520a-3p. Journal of Healthcare Engineering, 2022, Article ID: 2223149. [Google Scholar] [CrossRef] [PubMed]
[27] Zhang, Q., Liu, X.J., Li, Y., et al. (2021) Prognostic Value of Im-mune-Related lncRNA SBF2-AS1 in Diffuse Lower-Grade Glioma. Technology in Cancer Research & Treatment, 20. [Google Scholar] [CrossRef] [PubMed]
[28] Tian, Y.J., Wang, Y.H., Xiao, A.J., et al. (2019) Long Noncod-ing RNA SBF2-AS1 Act as a ceRNA to Modulate Cell Proliferation via Binding with miR-188-5p in Acute Myeloid Leukemia. Artificial Cells, Nanomedicine, and Biotechnology, 47, 1730-1737. [Google Scholar] [CrossRef] [PubMed]
[29] Huang, H.H., Chen, F.Y., Chou, W.C., et al. (2019) Long Non-Coding RNA HOXB-AS3 Promotes Myeloid Cell Proliferation and Its Higher Expression Is an Adverse Prognos-tic Marker in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome. BMC Cancer, 19, Article No. 617. [Google Scholar] [CrossRef] [PubMed]
[30] Chen, L., Hu, N., Wang, C., et al. (2020) HOTAIRM1 Knock-down Enhances Cytarabine-Induced Cytotoxicity by Suppression of Glycolysis through the Wnt/β-catenin/PFKP Path-way in Acute Myeloid Leukemia Cells. Archives of Biochemistry and Biophysics, 680, Article ID: 108244. [Google Scholar] [CrossRef] [PubMed]
[31] Wang, X., Zhang, L., Zhao, F., et al. (2018) Long Non-Coding RNA Taurine-Upregulated Gene 1 Correlates with Poor Prognosis, Induces Cell Proliferation, and Represses Cell Apoptosis via Targeting Aurora Kinase A in Adult Acute Myeloid Leukemia. Annals of Hematology, 97, 1375-1389. [Google Scholar] [CrossRef] [PubMed]
[32] Zhang, W., Liu, Y., Zhang, J., et al. (2020) Long Non-Coding RNA Taurine Upregulated Gene 1 Targets miR-185 to Regulate Cell Proliferation and Glycolysis in Acute Myeloid Leu-kemia Cells in Vitro. OncoTargets and Therapy, 13, 7887-7896. [Google Scholar] [CrossRef] 
[33] Sun, L.Y., Li, X.J., Sun, Y.M., et al. (2018) LncRNA ANRIL Regulates AML Development through Modulating the Glucose Metabolism Pathway of AdipoR1/AMPK/SIRT1. Molecular Cancer, 17, 127. [Google Scholar] [CrossRef] [PubMed]
[34] Zhai, H., Zhao, J., Pu, J., et al. (2021) LncRNA-DUXAP8 Regu-lation of the Wnt/β-Catenin Signaling Pathway to Inhibit Glycolysis and Induced Apoptosis in Acute Myeloid Leukemia. Turkish Journal of Hematology, 38, 264-272. [Google Scholar] [CrossRef] [PubMed]

为你推荐