支气管肺发育不良相关肺动脉高压的诊断方法进展
Progress in Diagnostic Methods for Pulmonary Arterial Hypertension Associated with Bronchopulmonary Dysplasia
DOI: 10.12677/ACM.2024.143820, PDF,   
作者: 郭映兰, 韦 红*：重庆医科大学附属儿童医院新生儿科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室，重庆
关键词: 支气管肺发育不良；肺动脉高压；诊断；诊断方法；Bronchopulmonary Dysplasia； Pulmonary Arterial Hypertension； Diagnosis； Diagnostic Methods
摘要: 支气管肺发育不良(bronchopulmonary dysplasia, BPD)是常见于早产儿的一种呼吸系统疾病，且预后欠佳，部分BPD患儿会合并有肺动脉高压，目前其发生机制尚未完善阐明，但临床研究发现，BPD-PH常与BPD的严重程度及患儿死亡风险相关。近年来，在医疗水平技术的提高及更多的研究发现下，BPD及PH的诊断标准有了一定的更新，本篇文章对BPD-PH的诊断及其各种诊断方式进行综述。
Abstract: Bronchopulmonary dysplasia (BPD) is a common respiratory disease in premature infants with poor prognosis. Some children with BPD may also have pulmonary arterial hypertension (PH), and the mechanism of its occurrence is not yet fully understood. Some clinical studies have found that BPD-PH is often associated with the severity of BPD and the risk of death in children. In recent years, with the improvement of medical technology and more research findings, the diagnostic criteria for BPD and PH have been updated to a certain extent. This article reviews the diagnosis of BPD-PH and its various diagnostic methods.
文章引用：郭映兰, 韦红. 支气管肺发育不良相关肺动脉高压的诊断方法进展[J]. 临床医学进展, 2024, 14(3): 1130-1136. https://doi.org/10.12677/ACM.2024.143820

参考文献

[1] Vayalthrikkovil, S., Vorhies, E., Stritzke, A., et al. (2019) Prospective Study of Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. Pediatric Pulmonology, 54, 171-178. [Google Scholar] [CrossRef] [PubMed]
[2] Thebaud, B., Goss, K.N., Laughon, M., et al. (2019) Bronchopul-monary Dysplasia. Nature Reviews Disease Primers, 5, Article No. 78. [Google Scholar] [CrossRef] [PubMed]
[3] Schmidt, A.R. and Ramamoorthy, C. (2022) Bronchopul-monary Dysplasia. Pediatric Anesthesia, 32, 174-180. [Google Scholar] [CrossRef] [PubMed]
[4] 虞嘉碧, 李娟. 重度支气管肺发育不良的管理现状[J]. 中国小儿急救医学, 2021, 28(1): 55-58.
[5] An, H.S., Bae, E.J., Kim, G.B., et al. (2010) Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia. Korean Circulation Journal, 40, 131-136. [Google Scholar] [CrossRef] [PubMed]
[6] 陈春, 黄鹏, 林冰纯, 等. 早产儿支气管肺发育不良伴肺动脉高压的高危因素与转归[J]. 中华儿科杂志, 2020, 58(9): 747-752.
[7] Jobe, A.H. and Bancalari, E. (2001) Bronchopulmonary Dysplasia. American Journal of Respiratory and Critical Care Medicine, 163, 1723-1729. [Google Scholar] [CrossRef] [PubMed]
[8] Higgins, R.D., Jobe, A.H., Koso-Thomas, M., et al. (2018) Bronchopulmonary Dysplasia: Executive Summary of a Workshop. The Journal of Pediatrics, 197, 300-308. [Google Scholar] [CrossRef] [PubMed]
[9] Abman, S.H., Hansmann, G., Archer, S.L., et al. (2015) Pediatric Pulmonary Hypertension: Guidelines from the American Heart Association and American Thoracic So-ciety. Circulation, 132, 2037-2099. [Google Scholar] [CrossRef] 
[10] Simonneau, G., Montani, D., Celermajer, D.S., et al. (2019) Haemodynamic Definitions and Updated Clinical Classification of Pulmonary Hypertension. European Respiratory Journal, 53, Article ID: 1801916. [Google Scholar] [CrossRef] [PubMed]
[11] 中华医学会小儿外科分会心脏学组, 国家儿童医学中心心血管专科联盟. 儿童先天性心脏病相关性肺高压诊断与治疗指南[J]. 中华小儿外科杂志, 2022, 43(11): 966-980. [Google Scholar] [CrossRef] 
[12] 中华医学会儿科学分会新生儿学组, 《中华儿科杂志》编辑委员会. 新生儿肺动脉高压诊治专家共识[J]. 中华儿科杂志, 2017, 55(3): 163-168. [Google Scholar] [CrossRef] [PubMed]
[13] Mirza, H., Ziegler, J., Ford, S., et al. (2014) Pulmonary Hypertension in Preterm Infants: Prevalence and Association with Bronchopulmonary Dysplasia. The Journal of Pediatrics, 165, 909-914.E1. [Google Scholar] [CrossRef] [PubMed]
[14] Krishnan, U., Feinstein, J.A., Adatia, I., et al. (2017) Eval-uation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia. The Journal of Pediatrics, 188, 24-34.E1. [Google Scholar] [CrossRef] [PubMed]
[15] 杜扬, 周建国, 陈超. 早产儿支气管肺发育不良相关肺动脉高压诊治研究进展[J]. 中华儿科杂志, 2020, 58(2): 162-165. [Google Scholar] [CrossRef] [PubMed]
[16] Altit, G., Lee, H.C., Hintz, S., et al. (2018) Practices Surrounding Pulmonary Hypertension and Bronchopulmonary Dysplasia amongst Neonatologists Caring for Premature Infants. Journal of Perinatology, 38, 361-367. [Google Scholar] [CrossRef] [PubMed]
[17] Levy, P.T., Jain, A., Nawaytou, H., et al. (2020) Risk As-sessment and Monitoring of Chronic Pulmonary Hypertension in Premature Infants. The Journal of Pediatrics, 217, 199-209.E4. [Google Scholar] [CrossRef] [PubMed]
[18] Hansmann, G., Koestenberger, M., Alastalo, T.P., et al. (2019) 2019 Updated Consensus Statement on the Diagnosis and Treatment of Pediatric Pulmonary Hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), Endorsed by AEPC, ESPR and ISHLT. The Journal of Heart and Lung Transplantation, 38, 879-901. [Google Scholar] [CrossRef] [PubMed]
[19] Levy, P.T., Levin, J., Leeman, K.T., et al. (2022) Diagnosis and Management of Pulmonary Hypertension in Infants with Bronchopulmonary Dysplasia. Seminars in Fetal and Neonatal Medicine, 27, Article ID: 101351. [Google Scholar] [CrossRef] [PubMed]
[20] Sanabria-Carretero, P., Ochoa-Osorio, C., Martin-Vega, A., et al. (2013) Anesthesia-Related Cardiac Arrest in Children. Data from a Tertiary Referral Hospital Registry. Revista Española de Anestesiología y Reanimación, 60, 424-433. [Google Scholar] [CrossRef] [PubMed]
[21] Hansmann, G., Apitz, C., Abdul-Khaliq, H., et al. (2016) Executive Summary. Expert Consensus Statement on the Diagnosis and Treatment of Paediatric Pulmonary Hy-pertension. The European Paediatric Pulmonary Vascular Disease Network, Endorsed by ISHLT and DGPK. Heart, 102, II86-II100. [Google Scholar] [CrossRef] [PubMed]
[22] 雷巧玲, 巨容, 赵奇思, 等. 氨基末端脑钠肽前体预测极低/超低出生体重儿支气管肺发育不良风险的研究[J]. 中华新生儿科杂志(中英文), 2022, 37(2): 123-127. [Google Scholar] [CrossRef] 
[23] 黄敏, 封志纯, 陈佳. 早产儿动脉导管未闭与B型脑钠肽及氨基末端脑钠肽前体相关性[J]. 中华实用儿科临床杂志, 2015, 30(10): 793-795. [Google Scholar] [CrossRef] 
[24] Konig, K., Guy, K.J., Nold-Petry, C.A., et al. (2016) BNP, Troponin I, and YKL-40 as Screening Markers in Extremely Preterm Infants at Risk for Pulmonary Hypertension Associated with Bronchopulmonary Dysplasia. The American Journal of Physiology-Lung Cellular and Molecular Physiology, 311, L1076-L1081. [Google Scholar] [CrossRef] [PubMed]
[25] Xiong, T., Kulkarni, M., Gokulakrishnan, G., et al. (2020) Natriuretic Peptides in Bronchopulmonary Dysplasia: A Systematic Review. Journal of Perinatology, 40, 607-615. [Google Scholar] [CrossRef] [PubMed]
[26] Trittmann, J.K., Peterson, E., Rogers, L.K., et al. (2015) Plasma Asymmetric Dimethylarginine Levels Are Increased in Neonates with Bronchopulmonary Dyspla-sia-Associated Pulmonary Hypertension. The Journal of Pediatrics, 166, 230-233. [Google Scholar] [CrossRef] [PubMed]
[27] Kim, D.H. and Kim, H.S. (2014) Serial Changes of Serum Endostatin and Angiopoietin-1 Levels in Preterm Infants with Severe Bronchopulmonary Dysplasia and Subsequent Pulmonary Artery Hypertension. Neonatology, 106, 55-61. [Google Scholar] [CrossRef] [PubMed]
[28] Vera, K.B., Moore, D., Flack, E., et al. (2012) Significant Differences in Markers of Oxidant Injury between Idiopathic and Bronchopulmonary-Dysplasia-Associated Pulmonary Hy-pertension in Children. Pulmonary Medicine, 2012, Article ID: 301475. [Google Scholar] [CrossRef] [PubMed]
[29] Yang, S., Lei, S., Peng, F., et al. (2022) Detection of Pulmonary Hypertension by Combining Echocardiography and Chest Radiography. Academic Radiology, 29, S23-S30. [Google Scholar] [CrossRef] [PubMed]
[30] 黎耀文, 徐淑敏, 曾洪武. 支气管肺发育不良影像学特征分析[J]. 中国小儿急救医学, 2022, 29(6): 412-417. [Google Scholar] [CrossRef] 
[31] Latus, H., Kuehne, T., Beerbaum, P., et al. (2016) Cardiac MR and CT Imaging in Children with Suspected or Confirmed Pulmonary Hypertension/Pulmonary Hypertensive Vascular Disease. Expert Consensus Statement on the Diagnosis and Treatment of Paediatric Pul-monary Hypertension. The European Paediatric Pulmonary Vascular Disease Network, Endorsed by ISHLT and DGPK. Heart, 102, Ii30-Ii35. [Google Scholar] [CrossRef] [PubMed]
[32] Higano, N.S., Bates, A.J., Gunatilaka, C.C., et al. (2022) Bronchopulmonary Dysplasia from Chest Radiographs to Magnetic Resonance Imaging and Computed Tomography: Adding Value. Pediatric Radiology, 52, 643-660. [Google Scholar] [CrossRef] [PubMed]
[33] Critser, P.J., Higano, N.S., Lang, S.M., et al. (2020) Car-diovascular Magnetic Resonance Imaging Derived Septal Curvature in Neonates with Bronchopulmonary Dysplasia Associated Pulmonary Hypertension. Journal of Cardiovascular Magnetic Resonance, 22, 50. [Google Scholar] [CrossRef] [PubMed]
[34] Critser, P.J., Higano, N.S., Tkach, J.A., et al. (2020) Car-diac Magnetic Resonance Imaging Evaluation of Neonatal Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine, 201, 73-82. [Google Scholar] [CrossRef] 
[35] 王鹏飞, 杨丽婵, 刘丹华. 肺动脉高压患儿心电图参数变化及与肺动脉的关系[J]. 山西卫生健康职业学院学报, 2022, 32(5): 56-57.
[36] Ley, L., Holtgen, R., Bogos-sian, H., et al. (2023) Electrocardiogram in Patients with Pulmonary Hypertension. Journal of Electrocardiology, 79, 24-29. [Google Scholar] [CrossRef] [PubMed]
[37] Waligora, M., Tyrka, A., Podolec, P., et al. (2018) ECG Markers of Hemodynamic Improvement in Patients with Pulmonary Hypertension. BioMed Research International, 2018, Article ID: 4606053. [Google Scholar] [CrossRef] [PubMed]
[38] Nakatsuji, A., Miyauchi, Y., Iwasaki, Y.K., et al. (2015) Detection and Evaluation of Pulmonary Hypertension by a Synthesized Right-Sided Chest Electrocardiogram. Journal of Nippon Medical School, 82, 136-145. [Google Scholar] [CrossRef] [PubMed]

为你推荐