LncRNA在缺血性卒中中的作用机制研究
Study on the Mechanism of LncRNA in Ischemic Stroke
DOI: 10.12677/acm.2024.14113034, PDF,   
作者: 黄文吉, 桑 爽:绍兴文理学院医学院,浙江 绍兴;姚超杰, 张小兵, 俞学斌*:绍兴市人民医院神经外科,浙江 绍兴
关键词: 长非编码RNA (LncRNA)缺血性脑卒中微肽作用机制综述Long Non-Coding RNAs (LncRNAs) Ischemic Stroke Micropeptide Mode of Action Overview
摘要: 缺血性脑卒中作为全球发病率、致残率最高的疾病之一。其会引起中枢神经系统功能障碍、神经炎症和神经元死亡等一系列病理生理改变,临床预后较差。长非编码RNA (LncRNA)作为非编码RNA家族中的一员,近些年在肿瘤、心血管疾病和神经退行性疾病等领域成为研究的热点。近期通过对缺血性卒中的细胞、动物模型以及临床患者的样本进行测序分析,均发现它们的LncRNA转录谱存在显著差异。进一步研究表明,表达异常的LncRNA参与了缺血性卒中引发的细胞凋亡、细胞自噬、免疫炎症、氧化应激以及血管生成等病理生理过程,并通过不同层面的调控机制对卒中的预后产生正面或负面的影响。本文将对LncRNA转录前后调控等机制进行探讨,以阐明LncRNA调控链与缺血性卒中转归之间的关系,为缺血性卒中患者治疗提供新的思路。
Abstract: Ischemic stroke, a global leader in both incidence and disability rates, triggers a cascade of pathological changes within the central nervous system: dysfunction, neuroinflammation, and neuronal loss, frequently accompanied by bleak prognoses. Among the non-coding RNA family, long non-coding RNAs (LncRNAs) have lately captivated scientific interest across disciplines like oncology, cardiovascular diseases, and neurodegeneration. Recent sequencing endeavors in cellular models, animal studies, and actual ischemic stroke patient samples have unveiled marked discrepancies in LncRNA expression patterns. Advancing these findings, it’s been elucidated that dysregulated LncRNAs are embroiled in the intricate mechanisms following stroke, such as cell death, autophagy, immune responses, and vascular formation, influencing recovery either detrimentally or beneficially through multifaceted regulatory pathways. This discourse delves into the intricacies of LncRNA modulation—genetic, transcriptional, and post-transcriptional—to illuminate how this regulatory network intersects with stroke outcomes, paving the way for innovative therapeutic strategies in ischemic stroke management.
文章引用:黄文吉, 姚超杰, 张小兵, 桑爽, 俞学斌. LncRNA在缺血性卒中中的作用机制研究[J]. 临床医学进展, 2024, 14(11): 1470-1477. https://doi.org/10.12677/acm.2024.14113034

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