维生素D与矮小症儿童青少年的相关研究进展
Research Progress on the Correlation between Vitamin D and Dwarfism in Children and Adolescents
DOI: 10.12677/jcpm.2024.34325, PDF,   
作者: 韩 雪：济宁医学院临床医学院，山东 济宁；李 萍*：济宁医学院附属医院内分泌科，山东 济宁
关键词: 维生素D；维生素D缺乏；矮小症；生长激素；Vitamin D； Vitamin D Deficiency； Short Stature； Growth Hormone
摘要: 矮小症包括生长激素缺乏症(GHD)、特发性身材矮小(ISS)、小于胎龄儿(SGA)、精神心理性身材矮小等。主要表现为身高低于同龄儿童，如未及时发现与治疗，将对儿童身心健康产生一定不利影响。在研究过程中发现维生素D在矮小症的致病机制、临床表现、治疗、监测等方面均有一定参与作用。因此，本文总结了一些国内外文献，对维生素D在矮小症患者中的影响及发挥的作用进行简要阐述。
Abstract: Short stature includes growth hormone deficiency (GHD), idiopathic short stature (ISS), small for gestational age (SGA), psychogenic short stature, etc. The main manifestation is that the height is lower than that of children of the same age. If not detected and treated in a timely manner, it will have a certain adverse effect on the physical and mental health of children. During the research process, it was found that vitamin D plays a certain role in the pathogenesis, clinical manifestations, treatment, monitoring, and other aspects of dwarfism. Therefore, this article summarizes some domestic and foreign literature, briefly elaborating on the impact and role of vitamin D in patients with dwarfism.
文章引用：韩雪, 李萍. 维生素D与矮小症儿童青少年的相关研究进展[J]. 临床个性化医学, 2024, 3(4): 2284-2290. https://doi.org/10.12677/jcpm.2024.34325

参考文献

[1] Choi, S.K., Park, M.S., Song, J.K., Yoon, K.S., Yoon, K.L. and Shim, K.S. (2013) Association of Polymorphisms in the Vitamin D Receptor Promoter with Idiopathic Short Stature. Journal of Korean Medical Science, 28, 1329-1333. [Google Scholar] [CrossRef] [PubMed]
[2] 吴铁牛, 肖柏, 涂琼. 赣南地区儿童矮小症发生情况及病因调查分析[J]. 中国妇幼保健, 2023, 38(19): 3748-3752.
[3] Wilson, L.R., Tripkovic, L., Hart, K.H. and Lanham-New, S.A. (2017) Vitamin D Deficiency as a Public Health Issue: Using Vitamin D2 or Vitamin D3 in Future Fortification Strategies. Proceedings of the Nutrition Society, 76, 392-399. [Google Scholar] [CrossRef] [PubMed]
[4] Amrein, K., Scherkl, M., Hoffmann, M., Neuwersch-Sommeregger, S., Köstenberger, M., Tmava Berisha, A., et al. (2020) Vitamin D Deficiency 2.0: An Update on the Current Status Worldwide. European Journal of Clinical Nutrition, 74, 1498-1513. [Google Scholar] [CrossRef] [PubMed]
[5] Siddiqee, M.H., Bhattacharjee, B., Siddiqi, U.R. and MeshbahurRahman, M. (2021) High Prevalence of Vitamin D Deficiency among the South Asian Adults: A Systematic Review and Meta-Analysis. BMC Public Health, 21, Article No. 1823. [Google Scholar] [CrossRef] [PubMed]
[6] Pérez-Bravo, F., Duarte, L., Arredondo-Olguín, M., Iñiguez, G. and Castillo-Valenzuela, O. (2021) Vitamin D Status and Obesity in Children from Chile. European Journal of Clinical Nutrition, 76, 899-901. [Google Scholar] [CrossRef] [PubMed]
[7] 中国预防医学会儿童保健分会. 中国儿童维生素A、维生素D临床应用专家共识(2024) [J]. 中国儿童保健杂志, 2024, 32(4): 349-358+361.
[8] 张菲. 维生素D缺乏对儿童生长发育情况的影响研究[J]. 中国社区医师, 2022, 38(16): 39-41.
[9] 颜丽娟, 龚岱, 文湘兰, 等. 株洲地区6-12岁儿童矮小症患病情况及其影响因素分析[J]. 教育生物学杂志, 2022, 10(4): 292-296.
[10] 鲁燕飞, 金平. 矮小症患儿血清胰岛素样生长因子-1 25-羟维生素D水平及临床特征分析[J]. 中国妇幼保健, 2021, 36(11): 2580-2582.
[11] 贺莉, 吕加利, 李俊, 等. 血清皮质醇、胰岛素生长因子结合蛋白-3、25-羟维生素D在特发性矮小症患儿中的表达及意义[J]. 中国儿童保健杂志, 2024, 32(6): 678-681+686.
[12] 陈瑾, 陶林辉, 林爱琳, 等. 不同生长激素分泌状态的矮身材儿童25-(OH)D水平的研究[J]. 中国儿童保健杂志, 2020, 28(2): 219-221+229.
[13] Delecroix, C., Brauner, R. and Souberbielle, J. (2018) Vitamin D in Children with Growth Hormone Deficiency Due to Pituitary Stalk Interruption Syndrome. BMC Pediatrics, 18, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[14] 李一辰, 尚晓瑞, 何辉. 北京市婴儿早期维生素D营养状况与体格生长发育的关系[J]. 中国妇幼健康研究, 2021, 32(12): 1723-1728.
[15] Li, H., Huang, T., Xiao, P., Zhao, X., Liu, J., Cheng, H., et al. (2020) Widespread Vitamin D Deficiency and Its Sex-Specific Association with Adiposity in Chinese Children and Adolescents. Nutrition, 71, Article 110646. [Google Scholar] [CrossRef] [PubMed]
[16] Al-Agha, A., Mabkhoot, Y., Bahwirith, A., Mohammed, A., Ragbi, R., Allhabi, E., et al. (2020) Various Causative Factors and Associated Complications of Childhood Obesity in Jeddah, Western Region, Saudi Arabia. Annals of African Medicine, 19, 15-19. [Google Scholar] [CrossRef] [PubMed]
[17] Chang, E. and Kim, Y. (2017) Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats. Nutrients, 9, Article 338. [Google Scholar] [CrossRef] [PubMed]
[18] Lontchi-Yimagou, E., Kang, S., Goyal, A., Zhang, K., You, J.Y., Carey, M., et al. (2020) Insulin-Sensitizing Effects of Vitamin D Repletion Mediated by Adipocyte Vitamin D Receptor: Studies in Humans and Mice. Molecular Metabolism, 42, Article 101095. [Google Scholar] [CrossRef] [PubMed]
[19] Gou, H., Wang, Y., Liu, Y., Peng, C., He, W. and Sun, X. (2022) Efficacy of Vitamin D Supplementation on Child and Adolescent Overweight/Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. European Journal of Pediatrics, 182, 255-264. [Google Scholar] [CrossRef] [PubMed]
[20] Li, H., Zou, S., Li, B., Wang, T., Ma, Z., Luo, Q., et al. (2022) Serum Vitamin D Status among Healthy Children in Hainan, South China: A Multi-Center Analysis of 10,262 Children. Translational Pediatrics, 11, 1010-1017. [Google Scholar] [CrossRef] [PubMed]
[21] 何炜, 王琴, 王俐. 矮小症患儿维生素D水平及影响因素分析[J]. 中国健康教育, 2023, 39(5): 474-479.
[22] Smyczyńska, J., Pawelak, N., Hilczer, M., Łupińska, A., Lewiński, A. and Stawerska, R. (2023) The Variability of Vitamin D Concentrations in Short Children with Short Stature from Central Poland—The Effects of Insolation, Supplementation, and COVID-19 Pandemic Isolation. Nutrients, 15, Article 3629. [Google Scholar] [CrossRef] [PubMed]
[23] Huang, P., Ke, G., Lin, X., Wang, Q., Lu, W., Zeng, L., et al. (2022) Correlation Analysis between Vitamin A, D, and E Status with Altitude, Seasonal Variation, and Other Factors, among Children Aged 0-6 Years in a Chinese Population Living in the Tibetan Plateau of Ganzi Prefecture. Journal of Clinical Laboratory Analysis, 36, e24620. [Google Scholar] [CrossRef] [PubMed]
[24] Wang, S., Shao, N., Ding, Y., Cai, H., Zou, R. and Wang, C. (2022) The Relationship between Children’s Birth Time and Short Stature. Frontiers in Pediatrics, 9, Article 766448. [Google Scholar] [CrossRef] [PubMed]
[25] 钱昊, 俞艳梅, 吴琪, 等. 矮小症儿童骨密度与血清维生素D IGF-1 IGFBP-3的相关性分析[J]. 河北医学, 2022, 28(7): 1148-1152.
[26] Mazziotti, G., Lania, A.G. and Canalis, E. (2022) Skeletal Disorders Associated with the Growth Hormone-Insulin-Like Growth Factor 1 Axis. Nature Reviews Endocrinology, 18, 353-365. [Google Scholar] [CrossRef] [PubMed]
[27] Gou, Z., Li, F., Qiao, F., Maimaititusvn, G. and Liu, F. (2023) Causal Associations between Insulin-Like Growth Factor 1 and Vitamin D Levels: A Two-Sample Bidirectional Mendelian Randomization Study. Frontiers in Nutrition, 10, Article 1162442. [Google Scholar] [CrossRef] [PubMed]
[28] Li, W. and Yu, T. (2023) Relationship between 25-Hydroxyvitamin D and IGF1: A Cross-Sectional Study of the Third National Health and Nutrition Examination Survey Participants. Journal of Health, Population and Nutrition, 42, Article No. 35. [Google Scholar] [CrossRef] [PubMed]
[29] Bolshova, E.V., Ryznychuk, M.A. and Kvacheniuk, D.A. (2021) Analysis of the Vitamin D Receptor BSMI Gene Polymorphism in Children with Growth Hormone Deficiency. Wiadomości Lekarskie, 74, 498-503. [Google Scholar] [CrossRef] 
[30] Ryznychuk, M., Bolshova, O., Kvachenyuk, D., Sprinchuk, N. and Malinovska, T. (2023) Genetic Features of Children with Idiopathic Short Stature. Wiadomości Lekarskie, 76, 320-325. [Google Scholar] [CrossRef] [PubMed]
[31] Akter, R., Afrose, A., Sharmin, S., Rezwan, R., Rahman, M.R. and Neelotpol, S. (2022) A Comprehensive Look into the Association of Vitamin D Levels and Vitamin D Receptor Gene Polymorphism with Obesity in Children. Biomedicine & Pharmacotherapy, 153, Article 113285. [Google Scholar] [CrossRef] [PubMed]
[32] Alharazy, S. and Naseer, M.I. (2023) Use of Whole Exome Sequencing for Identification of Genetic Variants Related to Growth Hormone Deficiency and Short Stature: A Family-Based Study. Pakistan Journal of Medical Sciences, 39, 1337-1344. [Google Scholar] [CrossRef] [PubMed]
[33] 余蓉蓉, 张小燕. 矮小症患儿血清维生素D、相关元素及其与患儿体格、生长激素、胰岛素样生长因子-1的相关性[J]. 中国现代医学杂志, 2022, 32(9): 78-83.
[34] Xu, B., Feng, Y., Gan, L., Zhang, Y., Jiang, W., Feng, J., et al. (2021) Vitamin D Status in Children with Short Stature: Accurate Determination of Serum Vitamin D Components Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry. Frontiers in Endocrinology, 12, Article 707283. [Google Scholar] [CrossRef] [PubMed]
[35] Li, J., Zhang, X., Xie, S., Feng, S. and Niu, M. (2021) Analysis of the Influence of High-Dose RHGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature. Evidence-Based Complementary and Alternative Medicine, 2021, 1-6. [Google Scholar] [CrossRef] [PubMed]
[36] Durá-Travé, T. and Gallinas-Victoriano, F. (2022) Vitamin D and Parathyroid Hormone during Growth Hormone Treatment. Children, 9, Article 725. [Google Scholar] [CrossRef] [PubMed]
[37] Wang, P., Jin, X., Zhang, Y., Zhang, J., Li, Y., Yang, S., et al. (2022) Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency. Disease Markers, 2022, 1-5. [Google Scholar] [CrossRef] [PubMed]
[38] Zhao, J., Miao, Y., Ying, X., et al. (2023) Effect of Recombinant Human Growth Hormone Plus Vitamin D on Development and Lipid Metabolism in Children with Growth Hormone Deficiency. Biotechnology & Genetic Engineering Reviews, 2023, 1-11.