间苯三酚和曲马多治疗夜间急性腹痛患者的疗效对比

Comparison of Efficacy of Phloroglucinol and Tramadol in Patients with Nighttime Acute Abdominal Pain

摘要: 目的：比较间苯三酚和曲马多治疗急诊科夜间急性腹痛患者的有效性与安全性，以期为临床用药决策提供一些理论支持。方法：回顾性分析新疆生产建设兵团第三师总医院急诊科自2023年03月至2024年06月夜间因腹痛急诊来院的89例患者，根据使用的不同镇痛药物将其分成两组。间苯三酚(试验组，n = 45例)，曲马多(观察组，n = 44例)。该试验使用视觉疼痛量表疼痛评分工具(VAS评分)比较了肌注间苯三酚和曲马多干预前后不同时机的镇痛效果。此外，还需观察对比药物注射后的效果、患者满意度、不良反应发生情况，以评估两种药物的安全性。当试验药物不能充分控制疼痛时，给予补救镇痛措施。结果：两组患者的一般资料进行比较，差异无统计学意义(P > 0.05)，可进行下一步比较；试验组在用间苯三酚干预后的第90 min后，疼痛相较于对照组明显缓解(2.03 ± 0.72 vs 2.47 ± 0.83, P < 0.001)；两组在干预后第30 min、第180 min的VAS评分、药物效果、患者满意度以及不良反应发生率等结局指标无统计学意义(P > 0.05)。结论：综上所述，间苯三酚虽然在干预90分钟后镇痛效果优于曲马多，但是两种药物基本具有相似的镇痛效果和安全性，可作为治疗夜间不明原因腹痛的不错选择。

Abstract: Objective: To compare the efficacy and safety of phloroglucinol and tramadol in patients with overnight unexplained acute abdominal pain in the emergency department, in order to provide some theoretical support for clinical medication decisions. Methods: A retrospective analysis of 89 patients present in the emergency department of the Third Division General Hospital of Xinjiang Production and Construction Corps during the night from March 2023 to June 2024 were divided into two groups according to the different analgesic drugs used. Phloroglucinol (test group, n = 45), tramadol (observation group, n = 44). This trial compared the analgesia of intertrophenol and tramadol intervention using the Visual Pain Scale pain scoring tool (VAS score). In addition, the effects of drug injection, patient satisfaction and adverse reactions should be observed to evaluate the safety of the two drugs. When the trial drug does not adequately control the pain, remedial analgesic measures are given. Results: A comparison was made on the general information of the two groups of patients, and there was no statistically significant difference (P > 0.05), so the next comparison could be carried out. In the test group, 90 minutes after being intervened with phloroglucinol, the pain was significantly relieved compared with that in the observation group (2.03 ± 0.72 vs 2.47 ± 0.83, P < 0.001). There was no statistically significant difference in the outcome indicators such as the Visual Analogue Scale (VAS) scores at the 30th minute and the 180th minute after the intervention, drug efficacy, patient satisfaction, and the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: In conclusion, although the analgesic effect of phloroglucinol is better than that of tramadol after 90 minutes of intervention, the two drugs basically have similar analgesic effects and safety, and can be used as a good choice for the treatment of unexplained abdominal pain at night.