Sema3F在神经系统中作用的研究
Study on the Role of Sema3F in the Nervous System
DOI: 10.12677/acm.2025.151019, PDF,    国家自然科学基金支持
作者: 杨泽睿*, 昝曼杰*, 杨雨佳, 胡可鑫, 张顺禹：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；杨光路#：内蒙古医科大学附属医院儿科，内蒙古 呼和浩特
关键词: Sema3F；神经系统；神经发育；神经系统疾病；Sema3F； Nervous System； Neurodevelopment； Neurological Disorders
摘要: 本文通过综述的形式，论述了保守轴突导向因子Semaphorins的信号蛋白Semaphorins3F (Sema3F)的在神经系统中作用的研究。基于对Sema3F的概述，我们对神经的作用进行了系统总结。在神经发育的过程中，Sema3F作为调节因子，参与皮层椎体神经元树突密度的调节及诱导树突消除和树突细胞体的回缩等多种功能。同样在对Sema3F在感觉神经中的作用的研究中，我们发现其对于嗅觉系统、视觉、内耳和牙神经等有着重要的作用。本文还探讨了Sema3F对于包括自闭症、精神分裂症和癫痫等神经系统疾病的作用。我们认为，Sema3F在神经元的发育、感觉神经以及多种神经系统疾病中均起着重要的作用。
Abstract: This article, in the form of a review, discusses the research on the role of the semaphorin family member Semaphorin 3F (Sema3F), a conserved axon guidance molecule, in the nervous system. Based on an overview of Sema3F, we systematically summarize its effects on neurons. During the process of neural development, Sema3F acts as a regulatory factor, participating in the modulation of dendritic density in cortical pyramidal neurons, as well as inducing dendritic elimination and retraction of dendritic cell bodies, among other functions. Similarly, in studies on the role of Sema3F in sensory neurons, we have found that it plays an important role in the olfactory system, vision, inner ear, and dental nerves. The article also explores the role of Sema3F in various neurological disorders, including autism, schizophrenia, and epilepsy. We believe that Sema3F plays a significant role in the development of neurons, sensory neurons, and a variety of neurological diseases.
文章引用：杨泽睿, 昝曼杰, 杨雨佳, 胡可鑫, 张顺禹, 杨光路. Sema3F在神经系统中作用的研究[J]. 临床医学进展, 2025, 15(1): 121-126. https://doi.org/10.12677/acm.2025.151019

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