炎症性肠病与肾脏疾病关系的研究进展
Research Progress on the Relationship between Inflammatory Bowel Disease and Kidney Diseases
DOI: 10.12677/acm.2025.151297, PDF,   
作者: 罗 茜, 卢贝贝, 廖晓辉*:重庆医科大学附属第二医院肾内科,重庆
关键词: 炎症性肠病肠外表现肾脏病Inflammatory Bowel Disease Extraintestinal Manifestations Kidney Diseases
摘要: 炎症性肠病(IBD)是一组主要发生在胃肠道粘膜的慢性炎症性疾病,包括溃疡性结肠炎(UC)和克罗恩病(CD)。除了影响胃肠道,IBD还具有多种肠外表现(EIM),其中肾脏受累是常见的并发症之一。研究表明,IBD可导致多种肾脏疾病,包括肾小球肾炎、肾小管间质性肾炎、肾结石、肾细胞癌、淀粉样变性、急性肾损伤和慢性肾脏病等。本文就IBD与肾脏疾病之间的研究进展进行综述,探讨IBD对肾脏健康的影响及其潜在机制。
Abstract: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders primarily affecting the gastrointestinal mucosa, including ulcerative colitis (UC) and Crohn’s disease (CD). In addition to gastrointestinal involvement, IBD is associated with various extraintestinal manifestations (EIM), with renal involvement being one of the common complications. Studies have shown that IBD can lead to multiple kidney diseases, including glomerulonephritis, interstitial nephritis, kidney stones, renal cell carcinoma, amyloidosis, acute kidney injury, and chronic kidney disease. This article reviews the research progress on the relationship between IBD and kidney diseases, exploring the impact of IBD on renal health and its potential mechanisms.
文章引用:罗茜, 卢贝贝, 廖晓辉. 炎症性肠病与肾脏疾病关系的研究进展[J]. 临床医学进展, 2025, 15(1): 2264-2269. https://doi.org/10.12677/acm.2025.151297

参考文献

[1] Pagani, K., Lukac, D., Bhukhan, A. and McGee, J.S. (2022) Cutaneous Manifestations of Inflammatory Bowel Disease: A Basic Overview. American Journal of Clinical Dermatology, 23, 481-497. [Google Scholar] [CrossRef] [PubMed]
[2] Park, S.H. and Park, S.H. (2022) Personalized Medicine in Inflammatory Bowel Disease: Perspectives on Asia. Journal of Gastroenterology and Hepatology, 37, 1434-1445. [Google Scholar] [CrossRef] [PubMed]
[3] Pardi, D.S., Tremaine, W.J., Sandborn, W.J. and McCarthy, J.T. (1998) Renal and Urologic Complications of Inflammatory Bowel Disease. American Journal of Gastroenterology, 93, 504-514. [Google Scholar] [CrossRef] [PubMed]
[4] Liu, T., Wu, Y., Cao, X., Yang, K., Tong, Y., Zhang, F., et al. (2024) Association between Sarcopenia and New-Onset Chronic Kidney Disease among Middle-Aged and Elder Adults: Findings from the China Health and Retirement Longitudinal Study. BMC Geriatrics, 24, Article No. 134. [Google Scholar] [CrossRef] [PubMed]
[5] Plonsky-Toder, M., Magen, D. and Pollack, S. (2023) Innate Immunity and CKD: Is There a Significant Association? Cells, 12, Article 2714. [Google Scholar] [CrossRef] [PubMed]
[6] Pattrapornpisut, P., Avila-Casado, C. and Reich, H.N. (2021) IgA Nephropathy: Core Curriculum 2021. American Journal of Kidney Diseases, 78, 429-441. [Google Scholar] [CrossRef] [PubMed]
[7] Rodrigues, J.C., Haas, M. and Reich, H.N. (2017) IgA Nephropathy. Clinical Journal of the American Society of Nephrology, 12, 677-686. [Google Scholar] [CrossRef] [PubMed]
[8] Ambruzs, J.M., Walker, P.D. and Larsen, C.P. (2014) The Histopathologic Spectrum of Kidney Biopsies in Patients with Inflammatory Bowel Disease. Clinical Journal of the American Society of Nephrology, 9, 265-270. [Google Scholar] [CrossRef] [PubMed]
[9] Nakayama, T., Kaneko, H., Okada, A., Suzuki, Y., Fujiu, K., Takeda, N., et al. (2024) Association of Inflammatory Bowel Disease with Incident IgA Nephropathy. Clinical Journal of the American Society of Nephrology, 19, 704-711. [Google Scholar] [CrossRef] [PubMed]
[10] Rehnberg, J., Symreng, A., Ludvigsson, J.F. and Emilsson, L. (2020) Inflammatory Bowel Disease Is More Common in Patients with IgA Nephropathy and Predicts Progression of ESKD: A Swedish Population-Based Cohort Study. Journal of the American Society of Nephrology, 32, 411-423. [Google Scholar] [CrossRef] [PubMed]
[11] Joher, N., Gosset, C., Guerrot, D., Pillebout, E., Hummel, A., Boffa, J., et al. (2021) Immunoglobulin a Nephropathy in Association with Inflammatory Bowel Diseases: Results from a National Study and Systematic Literature Review. Nephrology Dialysis Transplantation, 37, 531-539. [Google Scholar] [CrossRef] [PubMed]
[12] Barratt, J., Kristensen, J., Pedersen, C. and Jerling, M. (2024) Insights on Nefecon®, a Targeted-Release Formulation of Budesonide and Its Selective Immunomodulatory Effects in Patients with Iga Nephropathy. Drug Design, Development and Therapy, 18, 3415-3428. [Google Scholar] [CrossRef] [PubMed]
[13] Floege, J. (2024) IgA-Nephropathie. Die Urologie, 63, 103-111. [Google Scholar] [CrossRef] [PubMed]
[14] Lafayette, R., Kristensen, J., Stone, A., Floege, J., Tesař, V., Trimarchi, H., et al. (2023) Efficacy and Safety of a Targeted-Release Formulation of Budesonide in Patients with Primary IgA Nephropathy (NefigArd): 2-Year Results from a Randomised Phase 3 Trial. The Lancet, 402, 859-870. [Google Scholar] [CrossRef] [PubMed]
[15] Bian, J., Liebert, A., Bicknell, B., Chen, X., Huang, C. and Pollock, C.A. (2022) Faecal Microbiota Transplantation and Chronic Kidney Disease. Nutrients, 14, Article 2528. [Google Scholar] [CrossRef] [PubMed]
[16] Liu, M., Zhang, Y., Ye, Z., Yang, S., Zhou, C., He, P., et al. (2023) Inflammatory Bowel Disease with Chronic Kidney Disease and Acute Kidney Injury. American Journal of Preventive Medicine, 65, 1103-1112. [Google Scholar] [CrossRef] [PubMed]
[17] Singh, A., Khanna, T., Mahendru, D., Kahlon, J., Kumar, V., Sohal, A., et al. (2024) Insights into Renal and Urological Complications of Inflammatory Bowel Disease. World Journal of Nephrology, 13, Article 96574. [Google Scholar] [CrossRef] [PubMed]
[18] Saha, M.K., Hogan, S.L., Falk, R.J., Barnes, E.L., Hu, Y., Kshirsagar, A.V., et al. (2024) Acute Kidney Injury in Inflammatory Bowel Disease Patients: A Nationwide Comparative Analysis. Kidney Medicine, 6, Article 100836. [Google Scholar] [CrossRef] [PubMed]
[19] Yang, Y., Ludvigsson, J.F., Forss, A., Faucon, A., Faye, A.S., Olén, O., et al. (2024) Risk of Kidney Failure in Patients with Inflammatory Bowel Disease Undergoing Colectomy: A Nationwide Cohort Study. Clinical Gastroenterology and Hepatology, 22, 2291-2298.E17. [Google Scholar] [CrossRef] [PubMed]
[20] Joyce, E., Glasner, P., Ranganathan, S. and Swiatecka-Urban, A. (2016) Tubulointerstitial Nephritis: Diagnosis, Treatment, and Monitoring. Pediatric Nephrology, 32, 577-587. [Google Scholar] [CrossRef] [PubMed]
[21] van Hoeve, K. and Hoffman, I. (2022) Renal Manifestations in Inflammatory Bowel Disease: A Systematic Review. Journal of Gastroenterology, 57, 619-629. [Google Scholar] [CrossRef] [PubMed]
[22] Dimke, H., Winther-Jensen, M., Allin, K.H., Lund, L. and Jess, T. (2021) Risk of Urolithiasis in Patients with Inflammatory Bowel Disease: A Nationwide Danish Cohort Study 1977-2018. Clinical Gastroenterology and Hepatology, 19, 2532-2540.E2. [Google Scholar] [CrossRef] [PubMed]
[23] Wu, H., Liu, P., Gong, S., Liu, X., Hill, M.A., Liu, Z., et al. (2023) Inflammatory Bowel Disease Increases the Levels of Albuminuria and the Risk of Urolithiasis: A Two-Sample Mendelian Randomization Study. European Journal of Medical Research, 28, Article No. 167. [Google Scholar] [CrossRef] [PubMed]
[24] Ambruzs, J.M. and Larsen, C.P. (2018) Renal Manifestations of Inflammatory Bowel Disease. Rheumatic Disease Clinics of North America, 44, 699-714. [Google Scholar] [CrossRef] [PubMed]
[25] Nazzal, L., Puri, S. and Goldfarb, D.S. (2015) Enteric Hyperoxaluria: An Important Cause of End-Stage Kidney Disease. Nephrology Dialysis Transplantation, 31, 375-382. [Google Scholar] [CrossRef] [PubMed]
[26] Bernstein, C.N., Blanchard, J.F., Kliewer, E. and Wajda, A. (2001) Cancer Risk in Patients with Inflammatory Bowel Disease: A Population-Based Study. Cancer, 91, 854-862. [Google Scholar] [CrossRef
[27] Feng, D., Bai, Y., Liu, S., Yang, Y., Han, P. and Wei, W. (2021) Risk of Renal Cancer in Patients with Inflammatory Bowel Disease: A Pooled Analysis of Population-Based Studies. Urologic Oncology: Seminars and Original Investigations, 39, 93-99. [Google Scholar] [CrossRef] [PubMed]
[28] Derikx, L.A.A.P., Nissen, L.H.C., Drenth, J.P.H., van Herpen, C.M., Kievit, W., Verhoeven, R.H.A., et al. (2015) Better Survival of Renal Cell Carcinoma in Patients with Inflammatory Bowel Disease. Oncotarget, 6, 38336-38347. [Google Scholar] [CrossRef] [PubMed]
[29] Hall, E.C., Segev, D.L. and Engels, E.A. (2013) Racial/Ethnic Differences in Cancer Risk after Kidney Transplantation. American Journal of Transplantation, 13, 714-720. [Google Scholar] [CrossRef] [PubMed]
[30] Maisonneuve, P., Agodoa, L., Gellert, R., Stewart, J.H., Buccianti, G., Lowenfels, A.B., et al. (1999) Cancer in Patients on Dialysis for End-Stage Renal Disease: An International Collaborative Study. The Lancet, 354, 93-99. [Google Scholar] [CrossRef] [PubMed]
[31] Vajravelu, R.K., Copelovitch, L., Osterman, M.T., Scott, F.I., Mamtani, R., Lewis, J.D., et al. (2020) Inflammatory Bowel Diseases Are Associated with an Increased Risk for Chronic Kidney Disease, Which Decreases with Age. Clinical Gastroenterology and Hepatology, 18, 2262-2268. [Google Scholar] [CrossRef] [PubMed]
[32] Sattianayagam, P.T., Gillmore, J.D., Pinney, J.H., Gibbs, S.D.J., Wechalekar, A.D., Gilbertson, J.A., et al. (2013) Inflammatory Bowel Disease and Systemic AA Amyloidosis. Digestive Diseases and Sciences, 58, 1689-1697. [Google Scholar] [CrossRef] [PubMed]
[33] Meijers, B.K.I. and Evenepoel, P. (2011) The Gut-Kidney Axis: Indoxyl Sulfate, P-Cresyl Sulfate and CKD Progression. Nephrology Dialysis Transplantation, 26, 759-761. [Google Scholar] [CrossRef] [PubMed]
[34] Kriz, W. and Lehir, M. (2005) Pathways to Nephron Loss Starting from Glomerular Diseases—Insights from Animal Models. Kidney International, 67, 404-419. [Google Scholar] [CrossRef] [PubMed]
[35] Ranganathan, P., Jayakumar, C., Santhakumar, M. and Ramesh, G. (2013) Netrin-1 Regulates Colon-Kidney Cross Talk through Suppression of IL-6 Function in a Mouse Model of DSS-Colitis. American Journal of Physiology-Renal Physiology, 304, F1187-F1197. [Google Scholar] [CrossRef] [PubMed]
[36] Kellum, J.A., Romagnani, P., Ashuntantang, G., Ronco, C., Zarbock, A. and Anders, H. (2021) Acute Kidney Injury. Nature Reviews Disease Primers, 7, Article No. 52. [Google Scholar] [CrossRef] [PubMed]
[37] Schetz, M., Dasta, J., Goldstein, S. and Golper, T. (2005) Drug-Induced Acute Kidney Injury. Current Opinion in Critical Care, 11, 555-565. [Google Scholar] [CrossRef] [PubMed]
[38] Bennett, W.M. (1995) The Nephrotoxicity of Immunosuppressive Drugs. Clinical Nephrology, 43, S3-S7.
[39] Oikonomou, K.A., Kapsoritakis, A.N., Stefanidis, I. and Potamianos, S.P. (2011) Drug-Induced Nephrotoxicity in Inflammatory Bowel Disease. Nephron Clinical Practice, 119, c89-c96. [Google Scholar] [CrossRef] [PubMed]
[40] Den Broeder, A.A., Assmann, K.J., Van Riel, P.L., et al. (2003) Nephrotic Syndrome as a Complication of Anti-TN Falpha in a Patient with Rheumatoid Arthritis. The Netherlands Journal of Medicine, 61, 137-141.
[41] Tosca Cuquerella, J., Bosca-Watts, M.M., Anton Ausejo, R., Tejedor Alonso, S., Mora De Miguel, F. and Minguez Perez, M. (2016) Amyloidosis in Inflammatory Bowel Disease: A Systematic Review of Epidemiology, Clinical Features, and Treatment. Journal of Crohns and Colitis, 10, 1245-1253. [Google Scholar] [CrossRef] [PubMed]
[42] Guillo, L., Delanaye, P., Flamant, M., Figueres, L., Karam, S., Lemoine, S., et al. (2022) Kidney Function Monitoring in Inflammatory Bowel Disease: The MONITORED Consensus. Digestive and Liver Disease, 54, 309-315. [Google Scholar] [CrossRef] [PubMed]
[43] Zhao, L., Ren, G., Fan, R., Feng, X., Liu, Z., Cheng, Z., et al. (2021) Spectrum and Prognosis of Renal Histopathological Lesions in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study from a Single Center in China. Clinical and Experimental Medicine, 22, 629-635. [Google Scholar] [CrossRef] [PubMed]