铜死亡相关基因LIAS：疾病机制与治疗新方向
Cuproposis-Related Gene LIAS: Disease Mechanism and New Therapeutic Directions
DOI: 10.12677/acm.2025.153656, PDF,    科研立项经费支持
作者: 吴 琳, 亓同钢*：山东大学第二医院基础医学研究所，山东 济南
关键词: 硫辛酸合成酶(LIAS)；铜代谢；铜死亡；铜死亡相关基因；Lipoic Acid Synthase (LIAS)； Copper Metabolism； Cuproptosis； Cuproptosis-Related Genes
摘要: 硫辛酸合成酶(lipoic acid synthetase, LIAS)主要分布于线粒体之中，它具有多种活性，例如能够催化反应、结合铁离子、参与脂酸合成酶相关过程以及与金属离子结合，在脂酸生物合成这一过程中有着重要的参与作用。在正常生理状态下，LIAS基因发挥着合成硫辛酸的关键功能。硫辛酸是一种重要的辅酶，能够参与到众多重要的代谢过程中。Tsvetkov等人在2022年发现一种新型的调节性细胞死亡形式，称为“Cuproptosis”，它依赖于铜，受到调节，该途径与细胞凋亡、细胞焦亡、自噬、铁死亡等细胞死亡形式不同，同时Tsvetkov等人还鉴定了10个关键基因，LIAS就是其中之一。本文回顾了近年来对铜代谢作用机制的理解进展，重新整合了LIAS在代谢调控、免疫浸润中的作用，分析了LIAS与癌症等疾病的潜在关系，旨在为未来的研究提供理论支持和参考。
Abstract: Lipoic acid synthetase (LIAS) is mainly distributed in mitochondria, and it has a variety of activities, such as being able to catalyze reactions, bind iron ions, participate in fatty acid synthase-related processes, and bind to metal ions, and play an important role in the process of fatty acid biosynthesis. Under normal physiological conditions, the LIAS gene plays a key function in the synthesis of lipoic acid. Lipoic acid is an important coenzyme that is involved in many important metabolic processes. In 2022, Tsvetkov et al. discovered a novel form of regulatory cell death, called “Cuproptosis”, which is dependent on copper and is regulated, and this pathway is different from apoptosis, pyroptosis, autophagy, ferroptosis, etc., while Tsvetkov et al. also identified 10 key genes, LIAS is one of them. In this paper, we review the progress in understanding the mechanism of copper metabolism in recent years, reintegrate the role of LIAS in metabolic regulation and immune infiltration, and analyze the potential relationship between LIAS and cancer and other diseases, aiming to provide theoretical support and reference for future research.
文章引用：吴琳, 亓同钢. 铜死亡相关基因LIAS：疾病机制与治疗新方向[J]. 临床医学进展, 2025, 15(3): 621-628. https://doi.org/10.12677/acm.2025.153656

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