阿芬太尼的临床应用进展

Progress in Clinical Application of Alfentanil

摘要: 麻醉医师在进行麻醉操作时需要保证手术患者拥有良好的镇静、镇痛、肌肉松弛以及抑制麻醉与手术操作等引起的应激反应。阿片类药物在麻醉诱导和麻醉维持过程中可以使手术患者保持良好的镇痛效果以及获得舒适的手术体验。舒芬太尼以及瑞芬太尼等阿片类药物由于其镇痛效果良好，对人体循环、呼吸以及消化等系统产生的不良反应较强效镇痛药吗啡轻，现在已经在麻醉方面广泛应用。随着阿片类药物的发展，除了芬太尼、舒芬太尼、瑞芬太尼之外，国产阿芬太尼的出现在麻醉领域这一块展现除了自己独特的优势，使其逐渐在麻醉领域有了一席之地。阿芬太尼在国内研制成功并上市的时间短，在麻醉中的应用还处于摸索阶段，具有极大的科研价值。

Abstract: Anesthesiologists need to ensure that the patients have good sedation, analgesia, muscle relaxation and inhibit the stress reaction caused by anesthesia and surgical operation. Opioid drugs can keep good analgesic effect and obtain comfortable surgical experience in the process of anesthesia induction and anesthesia maintenance. Opioid drugs such as sufentanil and remifentanil have been widely used in anesthesia because of their good analgesic effect and less adverse reactions to human circulation, breathing and digestion systems than morphine, a powerful analgesic. With the development of opioid drugs, besides fentanyl, sufentanil and remifentanil, the emergence of domestic alfentanil in the field of anesthesia shows its unique advantages, which gradually makes it have a place in the field of anesthesia. Alfentanil has been successfully developed and marketed in China for a short time, and its application in anesthesia is still in the exploratory stage, which has great scientific research value.