空心结节——骨斑点症1例
Hollow Nodule—Osteopoikilosis: A Case Report
DOI: 10.12677/md.2025.152029, PDF,   
作者: 韩亚兰*：济宁医学院临床医学院(附属医院)，山东 济宁；张 琳#：济宁市第一人民医院放射科，山东 济宁
关键词: 骨斑点症；空心结节；X线；MRI；Osteopoikilosis； Hollow Nodules； X-Ray； MRI
摘要: 骨斑点症是一种极为罕见的骨的良性病变，临床上诊断主要依靠X线，关于MRI报道较少，既往报道骨斑点症患者MRI上多表现为致密结节，本文报道1例MRI表现为“空心结节”的骨斑点症。
Abstract: Osteopoikilosis is an extremely rare benign lesion of bone; the clinical diagnosis mainly relies on X-ray; the MRI report is less, previously reported that patients with osteopoikilosis on MRI mostly manifested as dense nodules. In this paper, we report a case of osteopoikilosis that manifested as “hollow nodules” on MRI.
文章引用：韩亚兰, 张琳. 空心结节——骨斑点症1例[J]. 医学诊断, 2025, 15(2): 217-221. https://doi.org/10.12677/md.2025.152029

参考文献

[1] 赵骄, 刘丽, 章振林. LEMD3基因突变导致骨斑点症1例报告及文献复习[J]. 中华骨质疏松和骨矿盐疾病杂志, 2019, 12(1): 65-70.
[2] 朱艳, 范红旗. LEMD3新突变位点所致的骨斑点症1例[J]. 中国骨与关节损伤杂志, 2024, 39(8): 895-896.
[3] Wordsworth, P. and Chan, M. (2019) Melorheostosis and Osteopoikilosis: A Review of Clinical Features and Pathogenesis. Calcified Tissue International, 104, 530-543. [Google Scholar] [CrossRef] [PubMed]
[4] Gnoli, M., Staals, E.L., Campanacci, L., Bedeschi, M.F., Faletra, F., Gallone, S., et al. (2019) Melorheostosis and Osteopoikilosis Clinical and Molecular Description of an Italian Case Series. Calcified Tissue International, 105, 215-221. [Google Scholar] [CrossRef] [PubMed]
[5] 蒋磊, 贾铭, 黄婵桃, 等. 4例骨斑点症的影像诊断研究[J]. 中国现代医学杂志, 2013, 23(25): 86-90.
[6] 周建军, 王荷燕, 吕静, 等. 骨斑点症的CT和MRI诊断价值[J]. 生物医学工程与临床, 2015, 19(4): 389-390+394.
[7] Chou, T.A. and Hsiao, C. (2022) Osteopoikilosis: Benign Bone Islands in Periarticular Bones. Medical Journal of Australia, 217, 397-397. [Google Scholar] [CrossRef] [PubMed]
[8] Yang, Y., Kang, Y. and Zheng, B. (2022) Spinal Vertebral Osteopoikilosis: A Case Report. Asian Journal of Surgery, 45, 2293-2295. [Google Scholar] [CrossRef] [PubMed]
[9] Chatterjee, P., Sureka, J., Joseph, E., Sudhakar, S. and Chittaranjan, S. (2009) Intraosseus and Extraosseus Juxtaarticular Calcification: Osteopoikilosis with Synovial Osteochondromatosis—An Association. Journal of Radiology Case Reports, 3, 1-5. [Google Scholar] [CrossRef] [PubMed]
[10] Frost, M., Rahbek, E.T., Ejersted, C., Høilund-Carlsen, P.F., Bygum, A., Thomsen, J.S., et al. (2020) Modeling-Based Bone Formation Transforms Trabeculae to Cortical Bone in the Sclerotic Areas in Buschke-Ollendorff Syndrome. A Case Study of Two Females with LEMD3 Variants. Bone, 135, Article 115313. [Google Scholar] [CrossRef] [PubMed]
[11] Ogbonnaya, A., Middleton, B., Cady, T. and Ho, C. (2014) Osteopoikilosis. The Lancet, 383, e4. [Google Scholar] [CrossRef] [PubMed]
[12] Kang, H., Jha, S., Deng, Z., Fratzl-Zelman, N., Cabral, W.A., Ivovic, A., et al. (2018) Somatic Activating Mutations in MAP2K1 Cause Melorheostosis. Nature Communications, 9, Article No. 1390. [Google Scholar] [CrossRef] [PubMed]
[13] Kotwal, A. and Clarke, B.L. (2017) Melorheostosis: A Rare Sclerosing Bone Dysplasia. Current Osteoporosis Reports, 15, 335-342. [Google Scholar] [CrossRef] [PubMed]
[14] Happle, R. (2003) Melorheostosis May Originate as a Type 2 Segmental Manifestation of Osteopoikilosis. American Journal of Medical Genetics Part A, 125, 221-223. [Google Scholar] [CrossRef] [PubMed]
[15] 金红花, 程若勤, 王化敏. 条纹状骨病一例[J]. 放射学实践, 2009, 24(8): 872.
[16] Panchal, S.R., Gawhale, S., Shah, N.Z. and Mohanty, T. (2021) Case Report of Osteopoikilosis: Sparse Cause of Bone Pain and Mimicker of Metastasis on Radiographs. Journal of Orthopaedic Case Reports, 11, 98-101. [Google Scholar] [CrossRef] [PubMed]