吲哚菁绿荧光显像技术在腹腔镜结直肠癌手术中的应用及其优势

Application and Advantages of Indocyanine Green Fluorescence Imaging in Laparoscopic Colorectal Cancer Surgery

摘要: 吲哚菁绿荧光显像技术(ICG-FI)在腹腔镜结直肠癌手术中展现出显著的临床价值。该技术通过术中实时、直观地显示肿瘤组织、淋巴引流路径及血管血流，为手术提供精准导航和评估。其核心优势在于：(1) 提升病灶定位精度：尤其对早期或黏膜下病变的识别更具优势；(2) 优化淋巴结清扫：清晰显影淋巴管和淋巴结，提高清扫彻底性及淋巴结检出数量，助力精准病理分期；(3) 评估吻合口血供：实时判断吻合组织灌注情况，降低术后吻合口漏风险。尽管ICG-FI面临组织穿透深度有限、设备依赖性、潜在过敏反应及个体代谢差异等挑战，但其在提高手术精准性、改善患者预后方面潜力巨大。随着技术进步，ICG-FI在腹腔镜结直肠癌手术中的应用前景广阔。

Abstract: Indocyanine green fluorescence imaging (ICG-FI) demonstrates significant clinical value in laparoscopic colorectal cancer surgery. This technique provides precise intraoperative navigation and assessment by enabling real-time, visual identification of tumor tissues, lymphatic drainage pathways, and blood flow. Its key advantages include: (1) Enhanced lesion localization precision, particularly in identifying early-stage or submucosal lesions ; (2) Optimized lymph node dissection, as it clearly visualizes lymphatic vessels and nodes, improving the completeness of dissection and increasing lymph node yield, which aids in accurate pathological staging; and (3) Evaluation of anastomotic blood perfusion, allowing real-time assessment of tissue perfusion at the anastomotic site to reduce the risk of postoperative anastomotic leakage. Although ICG-FI faces challenges such as limited tissue penetration depth, dependence on specialized equipment, potential allergic reactions, and individual metabolic variations, its potential to enhance surgical precision and improve patient outcomes is considerable. With ongoing technological advances, the application prospects of ICG-FI in laparoscopic colorectal cancer surgery are promising.