小肠肿瘤误诊为急性阑尾炎的临床分析
Clinical Analysis of Small Bowel Adenocarcinoma Misdiagnosed as Acute Appendicitis
摘要: 目的:分析小肠肿瘤的临床特征及诊断要点,提高术前诊断率,以减少临床工作中的误诊误治。方法:回顾性分析2023年1例小肠肿瘤误诊为急性阑尾炎患者的临床资料,并复习相关文献资料。结果:患者因间断右下腹痛1月余就诊于当地医院,考虑急性阑尾炎,给予行腹腔镜下阑尾切除术,术中发现阑尾与小肠黏连致密,完整切除困难,给予行阑尾部分切除,术后病理示因组织碎,无法明确浸润存次,少量游离组织考虑癌变。为进一步治疗转入我科,给予完善增强CT等检查,行多学科会诊,考虑患者为阑尾肿瘤合并小肠肿瘤可能性大,给予再次行手术治疗,术后病理证实患者原发肿瘤来自小肠。结论:小肠肿瘤发生率低,临床无特异性表现,诊断困难,对可疑患者应及时完善相关检查,联系多学科会诊,术中仔细探查,必要时术中送冰冻病理检查,以避免发生误诊。
Abstract: Objective: To analyze the clinical characteristics and diagnostic points of small bowel adenocarcinoma, improve the preoperative diagnosis rate, and reduce the misdiagnosis and mistreatment in clinical work. Methods: The clinical data of a case of small bowel adenocarcinoma misdiagnosed as acute appendicitis in 2023 were retrospectively analyzed, and the relevant literature was reviewed. Results: The patient was treated in a local hospital for intermittent right lower abdominal pain for more than a month. Considering acute appendicitis, laparoscopic appendectomy was performed. During the operation, it was found that the appendix was densely attached to the small intestine, making complete resection difficult, and partial appendectomy was performed. For further treatment, she was transferred to our department and given enhanced CT and other examinations and multi-disciplinary consultation. Considering that the patient had a high probability of appendiceal tumor complicated with small bowel adenocarcinoma, she was given another surgical treatment, and the postoperative pathology confirmed that the primary tumor of the patient came from the small bowel. Conclusion: The incidence of small bowel adenocarcinoma is low, there is no specific clinical manifestation, and diagnosis is difficult. For suspicious patients, relevant examinations should be improved in time, multi-disciplinary consultation should be contacted, intraoperative careful exploration should be conducted, and intraoperative frozen pathological examination should be sent when necessary to avoid misdiagnosis.
文章引用:冯立宗, 王顺正, 李广昊, 梁国刚, 陈玉, 王龙辉, 孙国志, 周云鹏. 小肠肿瘤误诊为急性阑尾炎的临床分析[J]. 临床医学进展, 2026, 16(1): 2291-2300. https://doi.org/10.12677/acm.2026.161287

参考文献

[1] Teufel, A., Meindl-Beinker, N.M., Hösel, P., Gerken, M., Roig, A., Ebert, M.P., et al. (2022) Characteristics and Outcome of Patients with Small Bowel Adenocarcinoma (SBA). Journal of Cancer Research and Clinical Oncology, 149, 4579-4590. [Google Scholar] [CrossRef] [PubMed]
[2] Aparicio, T., Zaanan, A., Svrcek, M., Laurent-Puig, P., Carrere, N., Manfredi, S., et al. (2014) Small Bowel Adenocarcinoma: Epidemiology, Risk Factors, Diagnosis and Treatment. Digestive and Liver Disease, 46, 97-104. [Google Scholar] [CrossRef] [PubMed]
[3] 仇长敬, 耿鹏. 小肠肿瘤误诊为急性阑尾炎1例报告[J]. 山东医药, 2014, 54(39): 18.
[4] 信延山, 曹清乐, 赵金明, 等. 误诊为炎症性肠病的小肠肿瘤一例[J]. 临床外科杂志, 2022, 30(9): 888-889.
[5] 支江平, 焦俊英. 以出血为首发症状的小肠肿瘤误诊分析[J]. 临床误诊误治, 2004(3): 188-189.
[6] 赵丹. 小肠恶性肿瘤患者临床特征分析[D]: [硕士学位论文]. 大连: 大连医科大学, 2020.
[7] Weiss, N.S. and Yang, C.P. (1987) Incidence of Histologic Types of Cancer of the Small Intestine. Journal of the National Cancer Institute, 78, 653-656.
[8] Chow, W., Linet, M.S., McLaughlin, J.K., Hsing, A.W., Co Chien, H.T. and Blot, W.J. (1993) Risk Factors for Small Intestine Cancer. Cancer Causes and Control, 4, 163-169. [Google Scholar] [CrossRef] [PubMed]
[9] de Bree, E., Rovers, K.P., Stamatiou, D., Souglakos, J., Michelakis, D. and de Hingh, I.H. (2018) The Evolving Management of Small Bowel Adenocarcinoma. Acta Oncologica, 57, 712-722. [Google Scholar] [CrossRef] [PubMed]
[10] 张硕文, 顾于蓓. 2023年小肠疾病诊治进展[J]. 诊断学理论与实践, 2024, 23(2): 119-125.
[11] 曲娟, 杨继志. 小肠克罗恩病误诊为小肠肿瘤1例[J]. 疑难病杂志, 2012, 11(4): 311.
[12] 俞利结, 李淑德, 傅传刚, 等. 小肠恶性肿瘤625例临床特征分析[J]. 肿瘤, 2012, 32(10): 811-818.
[13] 刘以俊, 谢文勇, 郑晟旻, 等. 血清CEA和CA19-9与原发性十二指肠癌临床病理特征及预后的关系[J]. 中华普通外科杂志2017, 32(8): 702-705.
[14] 叶红柔, 陈春晓. 双气囊小肠镜和多层螺旋CT对小肠肿瘤的诊断价值[J]. 浙江大学学报(医学版), 2017, 46(5): 557-562.
[15] 张婷, 朱佳慧, 廖专. 小肠胶囊内镜的临床应用价值[J]. 中国实用内科杂志, 2022, 42(1): 8-12.
[16] 万承凤, 张萍萍, 曾炳亮. CT小肠造影对克罗恩病与肠结核的鉴别诊断价值[J]. 实用临床医学, 2018, 19(10): 66-69, 108.
[17] 王勋. 肠结核与原发性小肠淋巴瘤的临床、内镜及CT特点的分析[J]. 现代中西医结合杂志, 2014, 23(27): 3035-3036, 3049.
[18] 贾国顺. 小肠憩室病7例误诊分析[J]. 青海医药杂志, 2019, 49(2): 65-66.
[19] 李成坤, 常旭东, 曹荣蓉, 等. 经双气囊小肠镜诊断小肠憩室内镜下表现及临床特点分析[J]. 临床军医杂志, 2023, 51(9): 892-895, 900.
[20] Vashistha, N. and Singhal, D. (2021) Current Oncologic Standards for Surgery of Small Bowel Cancers. Journal of Gastrointestinal Cancer, 53, 434-438. [Google Scholar] [CrossRef] [PubMed]
[21] Gelsomino, F., Balsano, R., De Lorenzo, S. and Garajová, I. (2022) Small Bowel Adenocarcinoma: From Molecular Insights to Clinical Management. Current Oncology, 29, 1223-1236. [Google Scholar] [CrossRef] [PubMed]
[22] Young, J.I., Mongoue-Tchokote, S., Wieghard, N., Mori, M., Vaccaro, G.M., Sheppard, B.C., et al. (2016) Treatment and Survival of Small-Bowel Adenocarcinoma in the United States. Diseases of the Colon & Rectum, 59, 306-315. [Google Scholar] [CrossRef] [PubMed]
[23] Falcone, R., Romiti, A., Filetti, M., Roberto, M., Righini, R., Botticelli, A., et al. (2019) Impact of Tumor Site on the Prognosis of Small Bowel Adenocarcinoma. Tumori Journal, 105, 524-528. [Google Scholar] [CrossRef] [PubMed]
[24] Ecker, B.L., McMillan, M.T., Datta, J., Mamtani, R., Giantonio, B.J., Dempsey, D.T., et al. (2015) Efficacy of Adjuvant Chemotherapy for Small Bowel Adenocarcinoma: A Propensity Score-Matched Analysis. Cancer, 122, 693-701. [Google Scholar] [CrossRef] [PubMed]
[25] Bilimoria, K.Y., Bentrem, D.J., Wayne, J.D., Ko, C.Y., Bennett, C.L. and Talamonti, M.S. (2009) Small Bowel Cancer in the United States: Changes in Epidemiology, Treatment, and Survival over the Last 20 Years. Annals of Surgery, 249, 63-71. [Google Scholar] [CrossRef] [PubMed]
[26] Ecker, B.L., McMillan, M.T., Datta, J., Lee, M.K., Karakousis, G.C., Vollmer, C.M., et al. (2016) Adjuvant Chemotherapy versus Chemoradiotherapy in the Management of Patients with Surgically Resected Duodenal Adenocarcinoma: A Propensity Score‐Matched Analysis of a Nationwide Clinical Oncology Database. Cancer, 123, 967-976. [Google Scholar] [CrossRef] [PubMed]