基于中医“治未病”理论的肝癌防治思路探讨
Exploration on Prevention and Treatment Ideas of Liver Cancer Based on TCM “Preventive Treatment of Disease” Theory
摘要: 原发性肝癌(以下简称肝癌)是我国高发恶性肿瘤,具有起病隐匿、进展迅猛、恶性度高、预后恶劣等特点,已成为危害公共卫生安全的重大问题。当前临床诊疗重心多聚焦于中晚期综合治疗,虽取得一定进展,但总体生存率仍难以实现根本性突破。因此,推动防治重心前移,构建全周期防控体系成为肝癌防治的关键方向。中医“治未病”理论源远流长,其“未病先防、既病防变、瘥后防复”的核心思想,与肝癌从慢性肝病(肝炎、肝纤维化、肝硬化)逐步演进的漫长病理过程高度契合。本文系统梳理“治未病”理论内涵,以该理论为框架,分别针对肝癌发生前的风险规避期(一级预防)、高危人群的防癌变期(二级预防/癌前病变干预)及治疗后的防复发期(三级预防),深入探讨中医防治肝癌的整体思路、核心原则与实践策略,为优化肝癌全程管理模式、丰富中医肿瘤学学术体系提供理论支撑与实践路径。
Abstract: Primary liver cancer (hereinafter referred to as liver cancer) is a highly prevalent malignant tumor in China, featuring insidious onset, rapid progression, high malignancy, and poor prognosis. It has become a major issue endangering public health security. Currently, the focus of clinical diagnosis and treatment is mostly on comprehensive treatment for middle and advanced stages. Despite achieving certain progress, a fundamental breakthrough in the overall survival rate remains difficult to realize. Therefore, advancing the focus of prevention and treatment and constructing a full-cycle prevention and control system have become the key direction for liver cancer prevention and treatment. The TCM theory of “Preventive Treatment of Disease (Zhi Wei Bing)” has a time-honored history, and its core ideas of “Preventing Disease Before Its Occurrence (Wei Bing Xian Fang)”, “Arresting Disease Progression After Its Onset (Ji Bing Fang Bian)” and “Preventing Recurrence After Recovery (Chai Hou Fang Fu)” are highly consistent with the prolonged pathological process of liver cancer evolving gradually from chronic liver diseases (hepatitis, liver fibrosis, cirrhosis). Based on this theory as a framework, this paper systematically sorts out the connotation of the “Preventive Treatment of Disease” theory, and deeply explores the overall ideas, core principles and practical strategies of TCM in preventing and treating liver cancer, targeting respectively the risk avoidance period before the occurrence of liver cancer (primary prevention), the cancer progression prevention period for high-risk groups (secondary prevention/precancerous lesion intervention), and the recurrence prevention period after liver cancer treatment (tertiary prevention). It aims to provide theoretical support and practical paths for optimizing the full-cycle management model of liver cancer and enriching the academic system of TCM oncology.
文章引用:李韩磊, 郭建恩. 基于中医“治未病”理论的肝癌防治思路探讨[J]. 中医学, 2026, 15(3): 7-15. https://doi.org/10.12677/tcm.2026.153125

参考文献

[1] Mejia, J.C. and Pasko, J. (2020) Primary Liver Cancers: Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma. Surgical Clinics of North America, 100, 535-549. [Google Scholar] [CrossRef] [PubMed]
[2] 李照, 朱继业. 《原发性肝癌诊疗指南(2024年版)》解读[J]. 临床肝胆病杂志, 2024, 40(7): 1324-1327.
[3] 中华人民共和国国家卫生健康委员会医药管理司. 原发性肝癌诊疗指南(2024年版) [J]. 磁共振成像, 2024, 15(6): 1-18.
[4] 李亚娟, 夏光萍, 郭敬镕, 等. 慢性乙型病毒性肝炎进展为原发性肝癌危险因素Meta分析[J]. 中国预防医学杂志, 2024, 25(6): 731-739.
[5] Dif, L., Manaud, G. and Moreau, V. (2025) Fascin-1 in Primary Liver Cancers, Perspectives for Targeted Therapy. Biochimica et Biophysica Acta (BBA)—Reviews on Cancer, 1880, Article ID: 189361. [Google Scholar] [CrossRef] [PubMed]
[6] 中华预防医学会肝胆胰疾病预防与控制专业委员会, 中国抗癌协会肝癌专业委员会, 北京医学会外科学分会肝脏学组, 等. 晚期肝细胞癌免疫靶向联合转化序贯外科治疗专家共识(2024版) [J]. 临床肝胆病杂志, 2025, 41(1): 30-40.
[7] 李生龙, 龚美胜, 李慧, 等. 基于“形气神”的《黄帝内经》治未病思想浅析[J]. 云南中医中药杂志, 2025, 46(10): 13-16.
[8] 李霞, 刘超, 冯全生. 从积聚源流论原发性肝癌的证治[J]. 中华中医药杂志, 2024, 39(7): 3340-3344.
[9] 黄婉婷, 郭涛, 张晶, 等. 原发性肝癌气滞血瘀证的研究进展[J]. 世界科学技术-中医药现代化, 2023, 25(11): 3724-3727.
[10] 袁伟琛, 周红光, 李文婷, 等. 中医药防治恶性肿瘤的现状、优势及策略[J]. 南京中医药大学学报, 2025, 41(6): 707-720.
[11] 殷克敬. 《黄帝内经》归来——中医“治未病”观探析[J]. 中国中医基础医学杂志, 2015, 21(6): 634-636.
[12] 任海燕, 田露, 郝征, 等. 《素问∙四气调神大论篇》“治未病”思想的发生及内涵探究[J]. 辽宁中医杂志, 2020, 47(3): 94-96.
[13] 区鸿斌, 陶衔, 金伟孝, 等. “见肝之病, 知肝传脾, 当先实脾”理论及其临床应用[J]. 中医杂志, 2011, 52(12): 1073-1075.
[14] 魏鹏辉, 江一平, 邓陈英. “见肝之病, 知肝传脾, 当先实脾”之实质[J]. 时珍国医国药, 2015, 26(11): 2732-2733.
[15] 孙志芳, 沈歆. 古代医籍中瘥后防复思想探析[J]. 光明中医, 2025, 40(7): 1286-1289.
[16] 骆文龙, 尹怡, 李姗, 等. 中医药通过调节糖代谢治疗原发性肝癌的研究进展[J]. 世界中医药, 2024, 19(12): 1840-1845.
[17] 李文轩, 游丽萍, 张雨琴, 等. 中成药对原发性肝癌的治疗研究进展[J]. 中华中医药学刊, 2024, 42(6): 141-145.
[18] 中国中医药学会肝胆疾病分会. 原发性肝癌中医诊疗指南[J]. 临床肝胆病杂志, 2024, 40(5): 919-927.
[19] 周洪立, 陈鲁豫, 秦媛媛, 等. 癌毒病机理论指导下病毒相关恶性肿瘤的防治[J]. 南京中医药大学学报, 2025, 41(11): 1414-1428.
[20] 李蕾蕾, 韦艾凌, 张永琴, 等. 从脏腑、气血津液、形神探讨原发性肝癌的防治思路[J]. 北京中医药大学学报, 2023, 46(7): 1020-1024.
[21] 刘昊辉, 陈仁寿, 卜岍岍, 等. 中医肿瘤病机的古代源流考辨[J]. 中华中医药杂志, 2025, 40(8): 4030-4034.
[22] 郭天灏, 李柳, 程海波. 基于癌毒病机理论浅谈中医预防肿瘤研究进展[J]. 时珍国医国药, 2025, 36(12): 2332-2338.
[23] 李宗艳, 施雁, 陈静娟, 等. 癌症患者心理焦虑测评工具的研究进展[J]. 淮海医药, 2021, 39(3): 326-329.
[24] 佚名. 黄帝内经[M]. 北京: 中医古籍出版社, 2010.
[25] 中国营养学会, 编. 中国居民膳食指南-2022 [M]. 北京: 人民卫生出版社, 2022.
[26] 王慧如, 于宁, 刘哲, 等. 《黄帝内经》体质学说与现代中医体质学说比较[J]. 中华中医药杂志, 2017, 32(4): 1458-1461.
[27] 陈珏, 吴苏, 廖蜀宁, 等. 络瘀生癌毒与恶性肿瘤[J]. 中华中医药杂志, 2024, 39(4): 2062-2065.
[28] 李霞, 刘文平, 冯全生, 等. 刍议肝癌之瘀[J]. 中华中医药杂志, 2022, 37(12): 7158-7161.
[29] 赵刚, 和水祥, 符寒, 等. 丹参酮IIA对人肝癌细胞TGF-β1基因表达的影响[J]. 胃肠病学和肝病学杂志, 2006(4): 396-398.
[30] Li, X., Gao, F., Wang, X., Liu, L., Gan, Y., Han, S., et al. (2023) Curcumol Exerts Antitumor Effect via Inhibiting EGFR-Akt-Mcl-1 Signaling. The American Journal of Chinese Medicine, 51, 741-760. [Google Scholar] [CrossRef] [PubMed]
[31] Saahene, R.O., Agbo, E., Barnes, P., Yahaya, E.S., Amoani, B., Nuvor, S.V., et al. (2021) A Review: Mechanism of Phyllanthus Urinaria in Cancers—NF-κB, P13K/AKT, and MAPKs Signaling Activation. Evidence-Based Complementary and Alternative Medicine, 2021, Article ID: 4514342. [Google Scholar] [CrossRef] [PubMed]
[32] Zhang, R., Ma, C., Wei, Y., Wang, X., Jia, J., Li, J., et al. (2021) Isolation, Purification, Structural Characteristics, Pharmacological Activities, and Combined Action of Hedyotis diffusa Polysaccharides: A Review. International Journal of Biological Macromolecules, 183, 119-131. [Google Scholar] [CrossRef] [PubMed]
[33] Dong, M., Li, J., Yang, D., Li, M. and Wei, J. (2023) Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from Astragalus membranaceus. Molecules, 28, Article 5018. [Google Scholar] [CrossRef] [PubMed]
[34] Guo, C., Guo, D., Fang, L., Sang, T., Wu, J., Guo, C., et al. (2021) Ganoderma lucidum Polysaccharide Modulates Gut Microbiota and Immune Cell Function to Inhibit Inflammation and Tumorigenesis in Colon. Carbohydrate Polymers, 267, Article ID: 118231. [Google Scholar] [CrossRef] [PubMed]
[35] Liu, C., Chen, K. and Chen, P. (2015) Treatment of Liver Cancer. Cold Spring Harbor Perspectives in Medicine, 5, a021535. [Google Scholar] [CrossRef] [PubMed]
[36] 耿雪尘, 张钦畅, 李柳, 等. 恶性肿瘤复发的核心病机及防治策略[J]. 南京中医药大学学报, 2025, 41(5): 561-566.
[37] 黄莉, 金凯, 王晨阳, 等. 基于细胞药动学的斑蝥素/黄芩苷配伍抗肝癌增效机制研究[J]. 中草药, 2026, 57(1): 185-193.
[38] 蔡修成, 李晓东. 中医药调控Hedgehog信号通路防治肝细胞癌的研究现状[J]. 临床肝胆病杂志, 2025, 41(11): 2403-2409.
[39] 王振华, 任一鹏, 麻宇超, 等. 加味白头翁汤对肝癌患者术后相关自噬蛋白水平的影响效应研究[J]. 中华中医药学刊, 2025, 43(11): 60-63.
[40] 蔡晓钧, 宋寓炜, 杨仁义, 等. 四逆散调节HPA轴和炎症水平改善肝癌抑郁样行为和抗肿瘤的机制研究[J]. 北京中医药大学学报, 2025, 48(11): 1507-1518.
[41] 朱燃培, 马清海, 张萍心, 等. 逍遥散及其核心加减方治疗恶性肿瘤的作用机制及临床应用进展[J]. 中草药, 2025, 56(20): 7564-7580.
[42] 王云云, 田丁, 桂郎, 等. 基于文献计量学的中药致肝毒性研究进展与趋势分析[J]. 中草药, 2026, 57(2): 595-609.
[43] 章新友, 李莹, 吴地尧, 等. 药食同源物质定量结构-活性关系肝毒性预测与评估方法研究[J]. 中国新药杂志, 2026, 35(1): 82-92.
[44] 邢华旭, 柴根旺. 活血化瘀法在慢性肝病治疗中的应用体会[J]. 山西中医学院学报, 2007(5): 44-46.
[45] 中国医师协会肝癌专业委员会, 孙居仙, 吴俊艺. 肝细胞癌合并肝静脉或下腔静脉癌栓多学科诊治中国专家共识(2025版) [J]. 中国实用外科杂志, 2025, 45(12): 1360-1367.
[46] 刘凡琪, 李楠, 王凤颖, 等. 细胞色素P450酶介导的中药注射剂代谢性相互作用研究现状及思考[J]. 药物评价研究, 2023, 46(5): 1116-1124.
[47] 中国抗癌协会肝癌专业委员会. 中国肝癌多学科综合治疗专家共识(2025年版) [J]. 临床肝胆病杂志, 2025, 41(7): 1279-1286.
[48] 向华, 龙林, 张永琎, 等. 肝癌局部治疗策略[J]. 临床肝胆病杂志, 2025, 41(8): 1497-1503.