中国典型抗生素污染特征、测试方法及生态风险评估综述
A Review on the Characteristics of Antibiotic Contamination, Analytical Methods, and Ecological Risks in China
DOI: 10.12677/aep.2026.162027, PDF,    科研立项经费支持
作者: 仝 瑶, 宿婧婧, 任明浩:华北水利水电大学地球科学与工程学院,河南 郑州;宋 寒*:河南省科学院质量检测与分析测试研究中心,河南 郑州;朱盈蕊:郑州市食品药品检验所,河南 郑州;李琦路:河南师范大学环境学院,黄淮水环境与污染防治教育部重点实验室,河南 新乡
关键词: 典型抗生素环境介质迁移转化检测方法生态风险Typical Antibiotics Environmental Media Migration and Transformation Detection Methods Ecological Risk
摘要: 论文系统总结了中国地表水、地下水及沉积物中磺胺类、喹诺酮类、大环内酯类和四环素类抗生素的污染分布特征及其环境行为。结果表明,磺胺类总体污染水平较低且区域差异不显著;喹诺酮类在经济发达、工农业活动密集区浓度偏高;大环内酯类空间差异明显,受局地排放源影响显著;四环素类在部分西北地区相对较高。河流中抗生素浓度整体高于湖泊,地下水以四环素类和喹诺酮类为主检出。抗生素迁移转化行为受理化性质及两性离子特征控制,与传统有机污染物存在明显差异。同步归纳了抗生素样品前处理及色谱–质谱联用检测技术,并比较了其环境适用性。生态风险评价结果显示,部分水环境已达到中至高等风险水平。上述认识可为抗生素环境行为研究及污染防控提供参考。
Abstract: This paper systematically summarizes the distribution characteristics and environmental behavior of sulfonamide, quinolone, macrolide, and tetracycline antibiotics in surface water, groundwater, and sediments in China. The results show that sulfonamide antibiotics generally have low pollution levels with no significant regional differences; quinolones have higher concentrations in economically developed areas with intensive industrial and agricultural activities; macrolides show significant spatial variations and are significantly influenced by local emission sources; and tetracyclines are relatively high in some northwestern regions. Antibiotic concentrations in rivers are generally higher than in lakes, and tetracyclines and quinolones are the main antibiotics detected in groundwater. The migration and transformation behavior of antibiotics is controlled by their physicochemical properties and zwitterionic characteristics, showing significant differences from traditional organic pollutants. The paper also summarizes antibiotic sample pretreatment and chromatography-mass spectrometry detection techniques and compares their environmental applicability. Ecological risk assessment results indicate that some aquatic environments have reached medium to high risk levels. These findings can provide a reference for research on the environmental behavior of antibiotics and pollution control.
文章引用:仝瑶, 宋寒, 朱盈蕊, 宿婧婧, 李琦路, 任明浩. 中国典型抗生素污染特征、测试方法及生态风险评估综述[J]. 环境保护前沿, 2026, 16(2): 260-275. https://doi.org/10.12677/aep.2026.162027

参考文献

[1] Wang, H., Gao, X. and Zuo, Y. (2024) Research and Application of Water Treatment Technologies for Emerging Contaminants (ECs): A Pathway to Solving Water Environment Challenges. Water, 16, Article No. 1837. [Google Scholar] [CrossRef
[2] Li, S., Shi, W., Liu, W., Li, H., Zhang, W., Hu, J., et al. (2018) A Duodecennial National Synthesis of Antibiotics in China’s Major Rivers and Seas (2005-2016). Science of the Total Environment, 615, 906-917. [Google Scholar] [CrossRef] [PubMed]
[3] 王亚韡, 张秋瑞, 于南洋, 等. 新污染物[J]. 化学进展, 2024, 36(11): 1607-1784.
[4] 彭怡荫, 陈希, 杨立彬, 刘畅, 郜学军, 卢仪思, 于茹月. 黄河流域新污染物研究发文现状分析及治理进展[J/OL]. 生态与农村环境学报, 2025-06-06. https://link.cnki.net/doi/10.19741/j.issn.1673-4831.2025.0268, 2025-10-12.[CrossRef
[5] Tang, J., Han, Y., Zha, Y. and Li, X. (2024) Distribution, Seasonal Characteristics, Ecological Risks and Human Health Risks of 9 Antibiotics in the Main Water Environment of Anhui Province, China. Frontiers in Environmental Science, 12, Article ID: 1408363. [Google Scholar] [CrossRef
[6] Liu, D., Xu, Y., Junaid, M., Zhu, Y. and Wang, J. (2022) Distribution, Transfer, Ecological and Human Health Risks of Antibiotics in Bay Ecosystems. Environment International, 158, Article ID: 106949. [Google Scholar] [CrossRef] [PubMed]
[7] Zhao, S., Liu, X., Cheng, D., Liu, G., Liang, B., Cui, B., et al. (2016) Temporal-Spatial Variation and Partitioning Prediction of Antibiotics in Surface Water and Sediments from the Intertidal Zones of the Yellow River Delta, China. Science of the Total Environment, 569, 1350-1358. [Google Scholar] [CrossRef] [PubMed]
[8] 赵晓帅, 郑其冰, 马瑞, 等. 北京市城市河流中抗生素的污染特征及多层次生态风险评估[J]. 环境科学, 2024, 45(6): 3165-3175.
[9] Tong, L., Huang, S., Wang, Y., Liu, H. and Li, M. (2014) Occurrence of Antibiotics in the Aquatic Environment of Jianghan Plain, Central China. Science of The Total Environment, 497, 180-187. [Google Scholar] [CrossRef] [PubMed]
[10] Li, S., Liu, Y., Wu, Y., Hu, J., Zhang, Y., Sun, Q., et al. (2022) Antibiotics in Global Rivers. National Science Open, 1, 99-119. [Google Scholar] [CrossRef
[11] Zhang, Q., Zhang, G., Liu, D., Zhang, X., Fang, R., Wang, L., et al. (2022) A Dataset of Distribution of Antibiotic Occurrence in Solid Environmental Matrices in China. Scientific Data, 9, Article No. 276. [Google Scholar] [CrossRef] [PubMed]
[12] Deng, W., Li, N. and Ying, G. (2018) Antibiotic Distribution, Risk Assessment, and Microbial Diversity in River Water and Sediment in Hong Kong. Environmental Geochemistry and Health, 40, 2191-2203. [Google Scholar] [CrossRef] [PubMed]
[13] Li, Y., Ding, J., Zhang, L., Liu, X. and Wang, G. (2019) Occurrence and Ranking of Pharmaceuticals in the Major Rivers of China. Science of the Total Environment, 696, Article ID: 133991. [Google Scholar] [CrossRef] [PubMed]
[14] Cao, S., Zhang, P., Halsall, C., Hou, Z. and Ge, L. (2024) Occurrence and Seasonal Variations of Antibiotic Micro-Pollutants in the Wei River, China. Environmental Research, 252, Article ID: 118863. [Google Scholar] [CrossRef] [PubMed]
[15] 任娇阳. 北京市潮白河流域抗生素污染分布与风险评估[D]: [硕士学位论文]. 北京: 北京交通大学, 2021.
[16] 牛颖, 安圣, 陈凯, 等. 2012~2021年中国地下水抗生素污染现状及分析技术研究进展[J]. 岩矿测试, 2023, 42(1): 39-58.
[17] 吴雯艳, 胡红美, 何鹏飞, 等. 水环境中磺胺类抗生素的超高效液相色谱-串联质谱法测定及其生态风险评估[J]. 分析化学, 2024, 52(8): 1182-1200.
[18] Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zaugg, S.D., Barber, L.B., et al. (2002) Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999-2000: A National Reconnaissance. Environmental Science & Technology, 36, 1202-1211. [Google Scholar] [CrossRef] [PubMed]
[19] Watkinson, A.J., Murby, E.J., Kolpin, D.W. and Costanzo, S.D. (2009) The Occurrence of Antibiotics in an Urban Watershed: From Wastewater to Drinking Water. Science of the Total Environment, 407, 2711-2723. [Google Scholar] [CrossRef] [PubMed]
[20] Ngumba, E., Gachanja, A. and Tuhkanen, T. (2016) Occurrence of Selected Antibiotics and Antiretroviral Drugs in Nairobi River Basin, Kenya. Science of the Total Environment, 539, 206-213. [Google Scholar] [CrossRef] [PubMed]
[21] Duan, W., Cui, H., Jia, X. and Huang, X. (2022) Occurrence and Ecotoxicity of Sulfonamides in the Aquatic Environment: A Review. Science of the Total Environment, 820, Article ID: 153178. [Google Scholar] [CrossRef] [PubMed]
[22] Dinh, Q.T., Moreau-Guigon, E., Labadie, P., Alliot, F., Teil, M., Blanchard, M., et al. (2017) Occurrence of Antibiotics in Rural Catchments. Chemosphere, 168, 483-490. [Google Scholar] [CrossRef] [PubMed]
[23] 于娇, 金凯馨, 吴玲玲. 浅谈抗生素在中国多介质中污染现状研究进展[J]. 应用化工, 2024, 53(7): 1635-1640.
[24] Li, Z., Li, M., Zhang, Z., Li, P., Zang, Y. and Liu, X. (2020) Antibiotics in Aquatic Environments of China: A Review and Meta-Analysis. Ecotoxicology and Environmental Safety, 199, Article ID: 110668. [Google Scholar] [CrossRef] [PubMed]
[25] 李清雪, 董天羽, 孙王茹, 等. 典型北方城市河流中抗生素污染特征及风险评价[J]. 生态毒理学报, 2022, 17(4): 213-229.
[26] Yu, Y., Wu, G., Wang, C., Lu, N., Yuan, X. and Zhu, X. (2019) Pollution Characteristics of Antibiotics and Antibiotic Resistance of Coliform Bacteria in the Yitong River, China. Environmental Monitoring and Assessment, 191, Article No. 516. [Google Scholar] [CrossRef] [PubMed]
[27] Lü, D., Yu, C., Zhuo, Z., Meng, S. and Liu, S. (2022) The Distribution and Ecological Risks of Antibiotics in Surface Water in Key Cities along the Lower Reaches of the Yellow River: A Case Study of Kaifeng City, China. China Geology, 5, 1-10. [Google Scholar] [CrossRef
[28] 韩金龙. 补水过程中喹诺酮类抗生素迁移规律研究[D]: [硕士学位论文]. 唐山: 华北理工大学, 2022.
[29] 孟顺龙, 李鸣霄, 陈曦, 等. 我国典型淡水水域环境中喹诺酮类抗生素污染的研究进展[J]. 农业环境科学学报, 2025, 44(3): 580-593.
[30] Ci, M., Zhang, G., Yan, X., Dong, W., Xu, W., Wang, W., et al. (2021) Occurrence of Antibiotics in the Xiaoqing River Basin and Antibiotic Source Contribution—A Case Study of Jinan City, China. Environmental Science and Pollution Research, 28, 25241-25254. [Google Scholar] [CrossRef] [PubMed]
[31] 封梦娟, 张芹, 宋宁慧, 等. 长江南京段水源水中抗生素的赋存特征与风险评估[J]. 环境科学, 2019, 40(12): 5286-5293.
[32] 蒋煜, 王世全, 杨帆, 等. 我国典型流域地表水中抗生素污染现状及生态风险评价[J]. 安全与环境工程, 2024, 31(6): 217-224.
[33] 陈卫平, 彭程伟, 杨阳, 等. 北京市地下水中典型抗生素分布特征与潜在风险[J]. 环境科学, 2017, 38(12): 5074-5080.
[34] 杨大杰, 欧阳友, 李炳华, 等. 我国水环境中喹诺酮类抗生素赋存特征及生态风险评估[J]. 人民黄河, 2022, 44(8): 97-108.
[35] 付彩霞, 宋伟, 裘文慧, 等. 粤港澳大湾区典型抗生素环境分布特征与生态风险[J]. 地球环境学报, 2024, 15(5): 711-727.
[36] 韩迁, 张玉娇, 赖承钺, 等. 成都市河流中四环素、喹诺酮类抗生素污染特征及生态风险评价[J]. 生态环境学报, 2023, 32(11): 1922-1932.
[37] 赵富强, 高会, 张克玉, 等. 中国典型河流水域抗生素的赋存状况及风险评估研究[J]. 环境污染与防治, 2021, 43(1): 94-102.
[38] 张凤娇, 毛旭锋, 魏晓燕, 等. 青海西宁城市湿地地表水中抗生素的赋存特征和生态风险[J]. 湿地科学, 2024, 22(3): 453-462.
[39] Li, Q., Gao, J., Zhang, Q., Liang, L. and Tao, H. (2017) Distribution and Risk Assessment of Antibiotics in a Typical River in North China Plain. Bulletin of Environmental Contamination and Toxicology, 98, 478-483. [Google Scholar] [CrossRef] [PubMed]
[40] 李敏. 水中多种大环内酯和磺胺抗生素的同时分析方法构建及应用研究[D]: [硕士学位论文]. 北京: 北京林业大学, 2023.
[41] 杨妍, 王子宇, 葛林科, 等. 我国水体中大环内酯类抗生素的分布特征及环境光化学行为[J]. 环境化学, 2024, 43(3): 734-750.
[42] 张文斌, 赵晶, 张秀, 等. 重庆市水环境中抗生素的污染特征及其风险评价[J]. 生态毒理学报, 2023, 18(6): 314-324.
[43] 黄丹瑜, 王晟, 程龙, 等. 南渡江流域抗生素污染的时空变化及多层次生态风险评估[J/OL]. 环境科学, 2025-01-14. https://link.cnki.net/doi/10.13227/j.hjkx.202501140, 2025-06-18.[CrossRef
[44] Cao, M., Fan, J., Guo, C., Chen, M., Lv, J., Sun, W., et al. (2023) Comprehensive Investigation and Risk Assessment of Organic Contaminants in Yellow River Estuary Using Suspect and Nontarget Screening Strategies. Environment International, 173, Article ID: 107843. [Google Scholar] [CrossRef] [PubMed]
[45] Lao, X., Tam, N.F.Y., Zhong, M., Wu, Q., Liu, Z., Huang, X., et al. (2024) Distribution and Risk Assessment of Antibiotic and Bisphenol Compounds Residues in Drinking Water Sources of Guangdong. Environmental Earth Sciences, 83, Article No. 475. [Google Scholar] [CrossRef
[46] 周瑞娟, 孟江红, 张卫红, 等. 黄河宁夏段干流PPCPs时空分布特征及生态风险评估[J]. 环境工程技术学报, 2025, 15(2): 610-620.
[47] Xu, L., Zhang, H., Xiong, P., Zhu, Q., Liao, C. and Jiang, G. (2021) Occurrence, Fate, and Risk Assessment of Typical Tetracycline Antibiotics in the Aquatic Environment: A Review. Science of the Total Environment, 753, Article ID: 141975. [Google Scholar] [CrossRef] [PubMed]
[48] Zhang, J., Yang, Y., Sun, C. and Wu, L. (2023) Sample Preparation and Instrumental Detection Methods for Tetracycline Antibiotics. International Journal of Environmental Analytical Chemistry, 104, 8102-8131. [Google Scholar] [CrossRef
[49] Zhang, Q., Ying, G., Pan, C., Liu, Y. and Zhao, J. (2015) Comprehensive Evaluation of Antibiotics Emission and Fate in the River Basins of China: Source Analysis, Multimedia Modeling, and Linkage to Bacterial Resistance. Environmental Science & Technology, 49, 6772-6782. [Google Scholar] [CrossRef] [PubMed]
[50] Matviichuk, O., Mondamert, L., Geffroy, C., Dagot, C. and Labanowski, J. (2023) Life in an Unsuspected Antibiotics World: River Biofilms. Water Research, 231, Article ID: 119611. [Google Scholar] [CrossRef] [PubMed]
[51] Moles, S., Gozzo, S., Ormad, M.P., Mosteo, R., Gómez, J., Laborda, F., et al. (2022) Long-Term Study of Antibiotic Presence in Ebro River Basin (Spain): Identification of the Emission Sources. Water, 14, Article No. 1033. [Google Scholar] [CrossRef
[52] Danner, M., Robertson, A., Behrends, V. and Reiss, J. (2019) Antibiotic Pollution in Surface Fresh Waters: Occurrence and Effects. Science of the Total Environment, 664, 793-804. [Google Scholar] [CrossRef] [PubMed]
[53] 张杨权, 栾杰, 冯琳, 等. 我国西南地区地表水抗生素分布特征及环境效应研究进展[J]. 中国公共卫生管理, 2025, 41(1): 62-66.
[54] Yi, C., Shang, J., Shen, Z., Sun, Y., Yang, Y., Zheng, X., et al. (2025) Distribution and Risk Characteristics of Antibiotics in China Surface Water from 2013 to 2024. Chemosphere, 375, Article ID: 144197. [Google Scholar] [CrossRef] [PubMed]
[55] Yin, Z. (2021) Distribution and Ecological Risk Assessment of Typical Antibiotics in the Surface Waters of Seven Major Rivers, China. Environmental Science: Processes & Impacts, 23, 1088-1100. [Google Scholar] [CrossRef] [PubMed]
[56] Zhang, C., Chen, Y., Chen, S., Guan, X., Zhong, Y. and Yang, Q. (2023) Occurrence, Risk Assessment, and in Vitro and in Vivo Toxicity of Antibiotics in Surface Water in China. Ecotoxicology and Environmental Safety, 255, Article ID: 114817. [Google Scholar] [CrossRef] [PubMed]
[57] 门聪, 蔡恒江, 傅晗, 等. 北京市通州区河流中抗生素的赋存特征、生态风险及主要来源[J]. 环境科学, 2025, 46(10): 6264-6273.
[58] Huang, F., An, Z., Moran, M.J. and Liu, F. (2020) Recognition of Typical Antibiotic Residues in Environmental Media Related to Groundwater in China (2009-2019). Journal of Hazardous Materials, 399, Article ID: 122813. [Google Scholar] [CrossRef] [PubMed]
[59] 陈桂淋, 武广元, 苏帆, 等. 我国地下水抗生素污染及生态风险研究进展[J]. 地下水, 2020, 42(5): 8-13.
[60] 王妍妍, 曹文庚, 龙敏, 等. 含抗生素地下水的时空分布、治理技术现状与进展[J/OL]. 中国地质, 2024-09-03.
https://link.cnki.net/urlid/11.1167.P.20240903.1111.004, 2025-08-09.
[61] 孔慧敏, 赵晓辉, 徐琬, 等. 我国地下水环境抗生素赋存现状及风险评价[J]. 环境工程, 2023, 41(2): 219-226.
[62] Wang, L., Li, H., Dang, J., Guo, H., Zhu, Y. and Han, W. (2021) Occurrence, Distribution, and Partitioning of Antibiotics in Surface Water and Sediment in a Typical Tributary of Yellow River, China. Environmental Science and Pollution Research, 28, 28207-28221. [Google Scholar] [CrossRef] [PubMed]
[63] 徐琳, 罗义, 徐冰洁. 海河底泥中12种抗生素残留的液相色谱串联质谱同时检测[J]. 分析测试学报, 2010, 29(1): 17-21.
[64] 刘叶新, 周志洪, 区晖, 等. 珠江广州河段沉积物中典型抗生素的污染特征[J]. 华南师范大学学报(自然科学版), 2018, 50(4): 48-54.
[65] 李威, 李佳熙, 李吉平, 等. 我国不同环境介质中的抗生素污染特征研究进展[J]. 南京林业大学学报(自然科学版), 2020, 44(1): 205-214.
[66] 沈娴, 李西西, 任浩宇, 等. 白洋淀不同功能区上覆水和沉积物典型抗生素的赋存与生态风险评价[J]. 湖泊科学, 2025, 37(6): 2077-2089.
[67] Liu, X., Lu, S., Guo, W., Xi, B. and Wang, W. (2018) Antibiotics in the Aquatic Environments: A Review of Lakes, China. Science of the Total Environment, 627, 1195-1208. [Google Scholar] [CrossRef] [PubMed]
[68] 陈金明, 卢少勇, 葛飞, 等. 东洞庭湖表层沉积物中抗生素及抗性基因的时空分异特征[J]. 农业资源与环境学报, 2024, 41(3): 697-705.
[69] 桑文才. 南四湖沉积物中抗生素及其抗性基因的赋存特征和环境风险[D]: [硕士学位论文]. 济南: 济南大学, 2023.
[70] Yuan, Q., Sui, M., Qin, C., Zhang, H., Sun, Y., Luo, S., et al. (2022) Migration, Transformation and Removal of Macrolide Antibiotics in the Environment: A Review. Environmental Science and Pollution Research, 29, 26045-26062. [Google Scholar] [CrossRef] [PubMed]
[71] 王晓娟, 年夫照, 夏运生, 等. 抗生素使用现状及其在生态环境系统的行为研究进展[J]. 中国土壤与肥料, 2020(6): 286-292.
[72] 田永静, 武宇圣, 黄天寅, 等. 我国地表水和沉积物PPCPs赋存与交互迁移影响因素[J]. 环境工程技术学报, 2023, 13(2): 585-596.
[73] 王浩加, 李子琼, 郑子帅, 等. 不同水文时期河流中典型抗生素的分配系数及其在沉积物中的生态风险[J]. 环境科学学报, 2026, 46(1): 178-193.
[74] 孟磊, 杨兵, 薛南冬. 氟喹诺酮类抗生素环境行为及其生态毒理研究进展[J]. 生态毒理学报, 2015, 10(2): 76-88.
[75] 王萌. 鄱阳湖周边水体典型抗生素检测、分布与生态风险评价[D]: [硕士学位论文]. 抚州: 东华理工大学, 2023.
[76] Luo, Y., Sun, Y., Wei, X., He, Y., Wang, H., Cui, Z., et al. (2024) Detection Methods for Antibiotics in Wastewater: A Review. Bioprocess and Biosystems Engineering, 47, 1433-1451. [Google Scholar] [CrossRef] [PubMed]
[77] Badawy, M.E.I., El-Nouby, M.A.M., Kimani, P.K., Lim, L.W. and Rabea, E.I. (2022) A Review of the Modern Principles and Applications of Solid-Phase Extraction Techniques in Chromatographic Analysis. Analytical Sciences, 38, 1457-1487. [Google Scholar] [CrossRef] [PubMed]
[78] 孟甜甜, 杨丰春, 赵传明, 等. 高效液相色谱-三重四极杆质谱联用法测定水体及土壤中6种抗生素[J]. 环境化学, 2024, 43(10): 3574-3578.
[79] 刘远飞. 珠三角典型城市制药企业和周边水环境抗生素的污染特征及风险评价[D]: [硕士学位论文]. 广州: 华南理工大学, 2023.
[80] Coleman, M.E. and Marks, H.M. (1999) Qualitative and Quantitative Risk Assessment. Food Control, 10, 289-297. [Google Scholar] [CrossRef
[81] 陈昱如. 长江流域典型抗生素的归趋模拟及风险削减研究[D]: [硕士学位论文]. 上海: 上海师范大学, 2024.
[82] Wang, J., Wei, H., Zhou, X., Li, K., Wu, W. and Guo, M. (2019) Occurrence and Risk Assessment of Antibiotics in the Xi’an Section of the Weihe River, Northwestern China. Marine Pollution Bulletin, 146, 794-800. [Google Scholar] [CrossRef] [PubMed]
[83] Shao, S., Hu, Y., Cheng, J. and Chen, Y. (2018) Research Progress on Distribution, Migration, Transformation of Antibiotics and Antibiotic Resistance Genes (ARGs) in Aquatic Environment. Critical Reviews in Biotechnology, 38, 1195-1208. [Google Scholar] [CrossRef] [PubMed]