糖尿病相关多种长期疾病流行趋势与死亡风险关联的研究综述
A Review of Trends in Diabetes-Related Multiple Long-Term Conditions and Mortality Risk
DOI: 10.12677/hjfns.2026.152017, PDF,    科研立项经费支持
作者: 阳路霜, 李继斌*, 殷佳伟*:重庆医科大学公共卫生学院营养与食品卫生学系,重庆
关键词: 糖尿病相关多种长期疾病趋势死亡Diabetes Multiple Long-Term Conditions Trend Mortality
摘要: 糖尿病是一种以慢性高血糖为特征的代谢性疾病,患者常合并多种慢性疾病,即糖尿病相关长期疾病(Multiple Long-Term Conditions, MLTC)。此类疾病的流行趋势及其与死亡风险的关联已成为全球公共卫生的重要议题。目前研究表明,糖尿病MLTC患病率一直居高不下,以心血管疾病、慢性肾脏病及抑郁症等为主要构成,且部分MLTC呈显著上升趋势。然而,针对糖尿病MLTC流行趋势及其与死亡风险关联的系统性证据仍显不足。未来研究需依托大规模、长周期、具有全国代表性的队列数据,系统梳理糖尿病MLTC的流行趋势,并整合其与死亡风险的关联证据,从而为糖尿病MLTC的综合管理提供科学依据。
Abstract: Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Patients with diabetes often develop multiple chronic conditions, known as diabetes-related multiple long-term conditions (MLTC). The epidemiological trends of MLTC and their association with mortality risk have emerged as a critical global public health issue. Current evidence indicates that the prevalence of diabetes MLTC remains high, with cardiovascular disease, chronic kidney disease, and depression being common components, and some MLTCs showing a significant upward trend. However, there is still a lack of systematic evidence regarding the epidemiological trends of diabetes MLTC and its association with mortality risk. Future studies should utilize large-scale, long-term, nationally representative cohort data to systematically examine the trends of diabetes MLTC and integrate evidence on its association with mortality risk, thereby providing a scientific basis for the comprehensive management of diabetes MLTC.
文章引用:阳路霜, 李继斌, 殷佳伟. 糖尿病相关多种长期疾病流行趋势与死亡风险关联的研究综述[J]. 食品与营养科学, 2026, 15(2): 153-160. https://doi.org/10.12677/hjfns.2026.152017

参考文献

[1] Federation, I.D. (2025) IDF Diabetes Atlas-2025. International Diabetes Federation.
[2] Einarson, T.R., Acs, A., Ludwig, C. and Panton, U.H. (2018) Prevalence of Cardiovascular Disease in Type 2 Diabetes: A Systematic Literature Review of Scientific Evidence from across the World in 2007-2017. Cardiovascular Diabetology, 17, Article No. 83. [Google Scholar] [CrossRef] [PubMed]
[3] Chu, L., Bhogal, S.K., Lin, P., Steele, A., Fuller, M., Ciaccia, A., et al. (2022) Awareness of Diagnosis and Treatment of Chronic Kidney Disease in Adults with Type 2 Diabetes (AWARE-CKD in T2d). Canadian Journal of Diabetes, 46, 464-472. [Google Scholar] [CrossRef] [PubMed]
[4] Ndumele, C.E., Neeland, I.J., Tuttle, K.R., Chow, S.L., Mathew, R.O., Khan, S.S., et al. (2023) A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement from the American Heart Association. Circulation, 148, 1636-1664. [Google Scholar] [CrossRef] [PubMed]
[5] Chiang, J.I., Hanlon, P., Li, T., Jani, B.D., Manski-Nankervis, J., Furler, J., et al. (2020) PLOS Medicine, 17, e1003094. [Google Scholar] [CrossRef
[6] Fried, L.P., Ferrucci, L., Darer, J., Williamson, J.D. and Anderson, G. (2004) Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59, M255-M263. [Google Scholar] [CrossRef] [PubMed]
[7] Chiang, J.I., Jani, B.D., Mair, F.S., Nicholl, B.I., Furler, J., O’Neal, D., et al. (2018) Associations between Multimorbidity, All-Cause Mortality and Glycaemia in People with Type 2 Diabetes: A Systematic Review. PLOS ONE, 13, e0209585. [Google Scholar] [CrossRef] [PubMed]
[8] Ho, I.S., Azcoaga-Lorenzo, A., Akbari, A., Black, C., Davies, J., Hodgins, P., et al. (2021) Examining Variation in the Measurement of Multimorbidity in Research: A Systematic Review of 566 Studies. The Lancet Public Health, 6, e587-e597. [Google Scholar] [CrossRef] [PubMed]
[9] Ho, I.S.S., Azcoaga-Lorenzo, A., Akbari, A., Davies, J., Khunti, K., Kadam, U.T., et al. (2022) Measuring Multimorbidity in Research: Delphi Consensus Study. BMJ Medicine, 1, e000247. [Google Scholar] [CrossRef] [PubMed]
[10] Khunti, K., Chudasama, Y.V., Gregg, E.W., Kamkuemah, M., Misra, S., Suls, J., et al. (2023) Diabetes and Multiple Long-Term Conditions: A Review of Our Current Global Health Challenge. Diabetes Care, 46, 2092-2101. [Google Scholar] [CrossRef] [PubMed]
[11] Heikkala, E., Mikkola, I., Jokelainen, J., Timonen, M. and Hagnäs, M. (2021) Multimorbidity and Achievement of Treatment Goals among Patients with Type 2 Diabetes: A Primary Care, Real-World Study. BMC Health Services Research, 21, Article No. 964. [Google Scholar] [CrossRef] [PubMed]
[12] Fu, Y., Chen, M. and Si, L. (2022) Multimorbidity and Catastrophic Health Expenditure among Patients with Diabetes in China: A Nationwide Population-Based Study. BMJ Global Health, 7, e007714. [Google Scholar] [CrossRef] [PubMed]
[13] Zghebi, S.S., Steinke, D.T., Rutter, M.K. and Ashcroft, D.M. (2020) Eleven-Year Multimorbidity Burden among 637 255 People with and without Type 2 Diabetes: A Population-Based Study Using Primary Care and Linked Hospitalisation Data. BMJ Open, 10, e033866. [Google Scholar] [CrossRef] [PubMed]
[14] Coles, B., Zaccardi, F., Hvid, C., Davies, M.J. and Khunti, K. (2021) Cardiovascular Events and Mortality in People with Type 2 Diabetes and Multimorbidity: A Real‐World Study of Patients Followed for up to 19 Years. Diabetes, Obesity and Metabolism, 23, 218-227. [Google Scholar] [CrossRef] [PubMed]
[15] Seng, J.J.B., Kwan, Y.H., Lee, V.S.Y., Tan, C.S., Zainudin, S.B., Thumboo, J., et al. (2020) Differential Health Care Use, Diabetes-Related Complications, and Mortality among Five Unique Classes of Patients with Type 2 Diabetes in Singapore: A Latent Class Analysis of 71,125 Patients. Diabetes Care, 43, 1048-1056. [Google Scholar] [CrossRef] [PubMed]
[16] Lynch, C.P., Gebregziabher, M., Axon, R.N., Hunt, K.E., Payne, E. and Egede, L.E. (2015) Geographic and Racial/Ethnic Variations in Patterns of Multimorbidity Burden in Patients with Type 2 Diabetes. Journal of General Internal Medicine, 30, 25-32. [Google Scholar] [CrossRef] [PubMed]
[17] Nowakowska, M., Zghebi, S.S., Ashcroft, D.M., Buchan, I., Chew-Graham, C., Holt, T., et al. (2019) The Comorbidity Burden of Type 2 Diabetes Mellitus: Patterns, Clusters and Predictions from a Large English Primary Care Cohort. BMC Medicine, 17, Article No. 145. [Google Scholar] [CrossRef] [PubMed]
[18] 李凌霞, 赵俊平. 2型糖尿病患者行血脂检验的诊断意义[J]. 智慧健康, 2019, 5(24): 14-15.
[19] Mosenzon, O., Alguwaihes, A., Leon, J.L.A., Bayram, F., Darmon, P., Davis, T.M.E., et al. (2021) CAPTURE: A Multinational, Cross-Sectional Study of Cardiovascular Disease Prevalence in Adults with Type 2 Diabetes across 13 Countries. Cardiovascular Diabetology, 20, Article No. 154. [Google Scholar] [CrossRef] [PubMed]
[20] Dibato, J.E., Montvida, O., Zaccardi, F., Sargeant, J.A., Davies, M.J., Khunti, K., et al. (2021) Association of Cardiometabolic Multimorbidity and Depression with Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S. Diabetes Care, 44, 231-239. [Google Scholar] [CrossRef] [PubMed]
[21] Fang, M., Wang, D., Coresh, J. and Selvin, E. (2021) Trends in Diabetes Treatment and Control in U.S. Adults, 1999-2018. New England Journal of Medicine, 384, 2219-2228. [Google Scholar] [CrossRef] [PubMed]
[22] Cui, G., Li, S., Qin, Y., Zhang, Y., Hui, K., Feng, M., et al. (2025) Trends, Social Determinants, and Lifestyle Factors Associated with Comorbidity of Diabetes and Kidney Diseases among Chinese Adults Aged ≥ 45 Years. Journal of Diabetes, 17, e70142. [Google Scholar] [CrossRef] [PubMed]
[23] Dibato, J., Montvida, O., Ling, J., Koye, D., Polonsky, W.H. and Paul, S.K. (2022) Temporal Trends in the Prevalence and Incidence of Depression and the Interplay of Comorbidities in Patients with Young-and Usual-Onset Type 2 Diabetes from the USA and the Uk. Diabetologia, 65, 2066-2077. [Google Scholar] [CrossRef] [PubMed]
[24] Faghir-Ganji, M., Abdolmohammadi, N., Nikbina, M., et al. (2024) Prevalence of Anemia in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis. Biomedical and Environmental Sciences, 37, 96-107.
[25] Chen, F., Yang, Y., Yu, L., Song, L., Zhang, C., He, Y., et al. (2025) The Association between Type 2 Diabetes and Asthma Incidence: A Longitudinal Analysis Considering Genetic Susceptibility. BMC Public Health, 25, Article No. 166. [Google Scholar] [CrossRef] [PubMed]
[26] Di Angelantonio, E., Kaptoge, S., Wormser, D., Willeit, P., Butterworth, A.S., Bansal, N., et al. (2015) Association of Cardiometabolic Multimorbidity with Mortality. JAMA, 314, 52-60. [Google Scholar] [CrossRef] [PubMed]
[27] Han, Y., Hu, Y., Yu, C., Sun, D., Pang, Y., Pei, P., et al. (2023) Duration-Dependent Impact of Cardiometabolic Diseases and Multimorbidity on All-Cause and Cause-Specific Mortality: A Prospective Cohort Study of 0.5 Million Participants. Cardiovascular Diabetology, 22, Article No. 135. [Google Scholar] [CrossRef] [PubMed]
[28] Charoensri, S., Kritmetapak, K., Tangpattanasiri, T. and Pongchaiyakul, C. (2021) The Impact of New-Onset Diabetes Mellitus and Hypertension on All-Cause Mortality in an Apparently Healthy Population: A Ten-Year Follow-Up Study. Journal of Diabetes Research, 2021, Article ID: 3964013. [Google Scholar] [CrossRef] [PubMed]
[29] McGuire, L.C., Ford, E.S. and Ajani, U.A. (2006) The Impact of Cognitive Functioning on Mortality and the Development of Functional Disability in Older Adults with Diabetes: The Second Longitudinal Study on Aging. BMC Geriatrics, 6, Article No. 8. [Google Scholar] [CrossRef] [PubMed]
[30] Zhu, Z. and Liao, H. (2020) Impact of Cognitive Impairment and Systemic Vascular Comorbidities on Risk of All-Cause and Cardiovascular Mortality: National Health and Nutrition Examination Survey 1999 to 2002. International Journal of Cardiology, 300, 255-261. [Google Scholar] [CrossRef] [PubMed]
[31] Wu, C.-S., Hsu, L.-Y. and Wang, S.-H. (2020) Association of Depression and Diabetes Complications and Mortality: A Population-Based Cohort Study. Epidemiology and Psychiatric Sciences, 29, e96. [Google Scholar] [CrossRef] [PubMed]
[32] Prigge, R., Wild, S.H. and Jackson, C.A. (2022) Depression, Diabetes, Comorbid Depression and Diabetes and Risk of All-Cause and Cause-Specific Mortality: A Prospective Cohort Study. Diabetologia, 65, 1450-1460. [Google Scholar] [CrossRef] [PubMed]
[33] Jia, G., Bai, H., Mather, B., Hill, M.A., Jia, G. and Sowers, J.R. (2024) Diabetic Vasculopathy: Molecular Mechanisms and Clinical Insights. International Journal of Molecular Sciences, 25, Article 804. [Google Scholar] [CrossRef] [PubMed]
[34] Wu, L., Gao, J., Zhuang, J., Wu, M., Chen, S., Wang, G., et al. (2023) Hypertension Combined with Atherosclerosis Increases the Risk of Heart Failure in Patients with Diabetes. Hypertension Research, 47, 921-933. [Google Scholar] [CrossRef] [PubMed]
[35] Vasquez-Rios, G., Katz, R., Levitan, E.B., Cushman, M., Parikh, C.R., Kimmel, P.L., et al. (2023) Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus. Kidney360, 4, e1257-e1264. [Google Scholar] [CrossRef] [PubMed]
[36] Dumbreck, S., Flynn, A., Nairn, M., Wilson, M., Treweek, S., Mercer, S.W., et al. (2015) Drug-Disease and Drug-Drug Interactions: Systematic Examination of Recommendations in 12 UK National Clinical Guidelines. BMJ, 350, h949-h949. [Google Scholar] [CrossRef] [PubMed]
[37] Coles, B., Zaccardi, F., Seidu, S., Gillies, C.L., Davies, M.J., Hvid, C., et al. (2021) Rates and Estimated Cost of Primary Care Consultations in People Diagnosed with Type 2 Diabetes and Comorbidities: A Retrospective Analysis of 8.9 Million Consultations. Diabetes, Obesity and Metabolism, 23, 1301-1310. [Google Scholar] [CrossRef] [PubMed]
[38] Gonzalez, J.S., Peyrot, M., McCarl, L.A., Collins, E.M., Serpa, L., Mimiaga, M.J., et al. (2008) Depression and Diabetes Treatment Nonadherence: A Meta-Analysis. Diabetes Care, 31, 2398-2403. [Google Scholar] [CrossRef] [PubMed]
[39] Kurdyak, P., Vigod, S., Duchen, R., Jacob, B., Stukel, T. and Kiran, T. (2017) Diabetes Quality of Care and Outcomes: Comparison of Individuals with and without Schizophrenia. General Hospital Psychiatry, 46, 7-13. [Google Scholar] [CrossRef] [PubMed]